Physicochemical studies of direct interactions between lung surfactant and components of electronic cigarettes liquid mixtures

Sosnowski, Tomasz R.; Jabłczyńska, Katarzyna; Odziomek, Marcin; Schlage, Walter K.; Kuczaj, Arkadiusz K.

doi:10.1080/08958378.2018.1478916

Cited by 43 publications

(45 citation statements)

References 59 publications

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“…3) to indicate clearly the concentration of a given CNM that corresponds to the most substantial alterations in LS dynamic surface activity. This relatively wide window embeds the scatter of data that is typically found in the multi-component system during the measurements of the dynamic surface tension during surface oscillations 32 . It is therefore assumed that results beyond this range may suggest that the dynamic surfactant activity has been altered to the degree that may have consequences for health.…”

Section: Resultsmentioning

confidence: 99%

“…These dynamics may be described using 2D rheological formalism, i.e. by determining the apparent surface elasticity and the apparent surface viscosity 31 , 32 . Several authors studied the surface rheology of air/liquid interfaces with different LS models 33 – 35 , however they did not focus on exact relations to the real breathing conditions (in terms of temperature and surface deformation frequency).…”

Section: Introductionmentioning

confidence: 99%

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Interfacial rheology for the assessment of potential health effects of inhaled carbon nanomaterials at variable breathing conditions

Kondej

Sosnowski

2020

Sci Rep

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Lung surface is the first line of contact between inhaled carbon nanomaterials, CNMs, and the organism, so this is the place where pulmonary health effects begin. The paper analyzes the influence of several CNMs (single-and multi-walled nanotubes with various surface area: 90-1,280 m 2 /g and aspect ratio: 8-3,750) on the surface-active properties of the lung surfactant, LS, model (Survanta). Effects of CNM concentration (0.1-1 mg/ml) and surface oscillation rate were determined using the oscillating drop method at simulated breathing conditions (2-10 s per cycle, 37 °C). Based on the values of apparent elasticity and viscosity of the interfacial region, new parameters: S ε and S μ were proposed to evaluate potential effect of particles on the LS at various breathing rates. Some of tested CNMs (e.g., COOH-functionalized short nanotubes) significantly influenced the surfactant dynamics, while the other had weaker effects even at high particle concentration. Analysis of changes in S ε and S μ provides a new way to evaluate of a possible disturbance of the basic functions of LS. The results show that the expected pulmonary effects caused by inhaled CNMs at variable breathing rate depend not only on particle concentration (inhaled dose) but also on their size, structure and surface properties. Carbon nanomaterials, CNMs, are used (or can be formed as by-products) in many applications, which can be associated with an unintentional release of nanometric dust to the air 1-7. The aerosol generated in this way is respirable (inhalable) and easily penetrates to the alveolar region of the respiratory system 8,9. A substantial number of inhaled nanoparticles that are deposited in this region can promote direct interactions with the organism 10-12. The first surface met by inhaled particles in the pulmonary region is a thin layer of alveolar liquid on the top of lung epithelium. This layer contains the mixture of specific compounds of the lung surfactant, LS-the structure, which plays a vital role in the physiological functions of the respiratory system 13. It has been recognized that LS is sensitive to inhaled materials 9,14-16 , and the resulting impairment of LS composition and/or properties may contribute to serious health problems, including the acute lung injury and respiratory distress. Accordingly, the analysis of LS properties in the presence of external factors such as micro/nanoparticles or chemicals, can give a preliminary information regarding the possible respiratory health problems that may follow inhalation of these agents 17-20. Because of the high surface-to-volume ratio, inhaled nanoparticles present a particular threat for health even when their deposited mass is not high 21. As shown by the recent studies 22,23 , effect of different nanomaterials on LS system may be highly specific and depend on several particle properties, such as the specific surface area, SSA or degree of hydrophobicity. Particle dose (concentration) is another essential factor in predicting lung toxicity 24. Therefore, the current stu...

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Interfacial rheology for the assessment of potential health effects of inhaled carbon nanomaterials at variable breathing conditions

Kondej

Sosnowski

2020

Sci Rep

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“…Electronic cigarettes are used as an alternative to cigarettes, but a high concentration of the major adsorbate glycerol and propylene may induce a decrease in the surface tension and hysteresis of the surfactant during compression. This effect would be more obvious in people who have already had lung diseases [ 206 ]. The side effect caused by ambient PM is not easy to be overcome by lung surfactant, as the inhibition gets stronger with time, leading to alveolar atelectasis [ 114 ].…”

Section: Interactions Of Particulate Matter and Pulmonary Surfactantmentioning

confidence: 99%

Interactions of particulate matter and pulmonary surfactant: Implications for human health

Wang

Liu

Zeng

2020

Advances in Colloid and Interface Science

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Particulate matter (PM), which is the primary contributor to air pollution, has become a pervasive global health threat. When PM enters into a respiratory tract, the first body tissues to be directly exposed are the cells of respiratory tissues and pulmonary surfactant. Pulmonary surfactant is a pivotal component to modulate surface tension of alveoli during respiration. Many studies have proved that PM would interact with pulmonary surfactant to affect the alveolar activity, and meanwhile, pulmonary surfactant would be adsorbed to the surface of PM to change the toxic effect of PM. This review focuses on recent studies of the interactions between micro/nanoparticles (synthesized and environmental particles) and pulmonary surfactant (natural surfactant and its models), as well as the health effects caused by PM through a few significant aspects, such as surface properties of PM, including size, surface charge, hydrophobicity, shape, chemical nature, etc. Moreover, in vitro and in vivo studies have shown that PM leads to oxidative stress, inflammatory response, fibrosis, and cancerization in living bodies. By providing a comprehensive picture of PM-surfactant interaction, this review will benefit both researchers for further studies and policy-makers for setting up more appropriate regulations to reduce the adverse effects of PM on public health.

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“…This aerosol consists of a suspension mixture of gases, vapors, and aqueous particles. The latter elements condense in submicrometer to micrometer size droplets that can be inhaled into the lungs (i.e., “vaped”) (35, 52).…”

Section: Introductionmentioning

confidence: 99%

“…These inflammatory molecules can induce microvascular leakage and airway constriction by stimulating specific receptors on smooth muscle cells in the airway wall (11, 25, 31, 38). Together, these effects may also disturb mucus/surfactant rheology properties, increase surface tension, and result in small-airway collapse (47, 52). The latter phenomenon can modify the ventilation-perfusion ratio by modulating airway as well as vascular tone and therefore disturb pulmonary gas exchange (44).…”

Section: Introductionmentioning

confidence: 99%

Fourth generation e-cigarette vaping induces transient lung inflammation and gas exchange disturbances: results from two randomized clinical trials

Chaumont

Borne

Bernard

et al. 2019

American Journal of Physiology-Lung Cellular and Molecular Phys

119

109

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When heated by an electronic cigarette, propylene glycol and glycerol produce a nicotine-carrying-aerosol. This hygroscopic/hyperosmolar aerosol can deposit deep within the lung. Whether these deposits trigger local inflammation and disturb pulmonary gas exchanges is not known. The aim of this study was to assess the acute effects of high-wattage electronic cigarette vaping with or without nicotine on lung inflammation biomarkers, transcutaneous gas tensions, and pulmonary function tests in young and healthy tobacco smokers. Acute effects of vaping without nicotine on arterial blood gas tensions were also assessed in heavy smokers suspected of coronary artery disease. Using a single-blind within-subjects study design, 25 young tobacco smokers underwent three experimental sessions in random order: sham-vaping and vaping with and without nicotine at 60 W. Twenty heavy smokers were also exposed to sham-vaping ( n = 10) or vaping without nicotine ( n = 10) in an open-label, randomized parallel study. In the young tobacco smokers, compared with sham-vaping: 1) serum club cell protein-16 increased after vaping without nicotine (mean ± SE, −0.5 ± 0.2 vs. +1.1 ± 0.3 µg/l, P = 0.013) and vaping with nicotine (+1.2 ± 0.3 µg/l, P = 0.009); 2) transcutaneous oxygen tension decreased for 60 min after vaping without nicotine (nadir, −0.3 ± 1 vs. −15.3 ± 2.3 mmHg, P < 0.001) and for 80-min after vaping with nicotine (nadir, −19.6 ± 2.8 mmHg, P < 0.001). Compared with sham vaping, vaping without nicotine decreased arterial oxygen tension for 5 min in heavy-smoking patients (+5.4 ± 3.3 vs. −5.4 ± 1.9 mmHg, P = 0.012). Acute vaping of propylene glycol/glycerol aerosol at high wattage with or without nicotine induces airway epithelial injury and sustained decrement in transcutaneous oxygen tension in young tobacco smokers. Intense vaping conditions also transiently impair arterial oxygen tension in heavy smokers.

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Physicochemical studies of direct interactions between lung surfactant and components of electronic cigarettes liquid mixtures

Cited by 43 publications

References 59 publications

Interfacial rheology for the assessment of potential health effects of inhaled carbon nanomaterials at variable breathing conditions

Interfacial rheology for the assessment of potential health effects of inhaled carbon nanomaterials at variable breathing conditions

Interactions of particulate matter and pulmonary surfactant: Implications for human health

Fourth generation e-cigarette vaping induces transient lung inflammation and gas exchange disturbances: results from two randomized clinical trials

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