Physicomechanical and physicochemical characterizations of biexponential compaction process of paracetamol in the presence of talcum-lubricated-MCC

Panda, B. B.; Digdarsini, Tanmayee; Mallick, Subrata

doi:10.1016/j.powtec.2014.12.039

Cited by 9 publications

(3 citation statements)

References 37 publications

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“…The pressures which have been used were 0.5,1, 1.5, 2 and 2.5 tons. 14 The dimensions and hardness was then measured for determination of various physical and mechanical properties. 8 Tensile strength was calculated by using formula: 15 Here, F is compression force applied in Newton force (unit: kg.m/S 2 ); d= diameter in meter, h=thickness of the tablet in meter.…”

Section: Direct Compressionmentioning

confidence: 99%

Quantitative Estimation of Tabletability of Aceclofenac after Incorporation of Titanium Dioxide using Area under the Curve

Nandi¹,

Mishra²,

Sahoo³

et al. 2019

IJPER

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Background: Tablet manufacturing with direct compression is one of the leading industrial technique that consumes less time, labour and economic also. But the choice of excipients are critical in this case which will allow the drug to get compressed without granulation techniques. Purpose: Aceclofenac is a BCS class II non-steroidal anti-inflammatory drug, which exerts a low oral bioavailability because of low solubility in aqueous medium. The drug also suffers from compressibility and also shows poor tabletibility. Methods: We have attempted to improve tabletability by incorporating titanium dioxide (TiO 2) through kneading and solvent evaporation technique. Results: In the FTIR study revealed that NH and Cl aromatic stretching of aceclofenac has been affected significantly due to binding with TiO 2. DSC thermogram ascertained the partial amorphization of the drug in the formulations. Evaluated tabletability from the area under the applied pressure vs tensile strength curve (AUTC) of A1T1 has shown a poor value in contrast to other formulations.

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Section: Direct Compressionmentioning

confidence: 99%

Quantitative Estimation of Tabletability of Aceclofenac after Incorporation of Titanium Dioxide using Area under the Curve

Nandi¹,

Mishra²,

Sahoo³

et al. 2019

IJPER

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“…In the coating, talcum powder as a promoter action will be added to the coating which can reduce manufacturing costs and improve the coating hardness [10]. In this paper, the talcum powder was added to waterborne UV curing wood coating, through orthogonal experiment to achieve the composition and curing conditions of process parameters optimization, trying to improve the mechanical properties of waterborne UV curing wood coating and achieve the sub gloss.…”

Section: Introductionmentioning

confidence: 99%

Effect of Single Modification of Talcum Powder on Mechanical Properties and Optical Properties of Waterborne UV Curing Coatings

Yan¹,

Cai²,

Xu³

et al. 2016

Proceedings of the 4th 2016 International Conference on Material Science and Engineering (ICMSE 2016)

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Abstract. The talcum powder was employed for the single modification of waterborne ultraviolet (UV) curing wood coatings, through optimizing process parameters to prepare the waterborne UV curing wood coatings. It was found that when talcum powder content in Waterborne UV curing wood coatings was at 2.0%, the waterborne UV curing wood coatings was dried firstly in 50°C oven for 30 min and then under UV light irradiation for 3 min, the obtained waterborne UV curing wood coating had good hardness, adhesion and impact strength. But when the content of talcum powder was more than 2.0%, the mechanical properties of waterborne UV curing wood decreased. The gloss measurement showed that waterborne UV curing wood coating gloss decreased with the increased talcum powder content, and when the talcum powder contents were more than 2.0%, waterborne UV curing wood coating showed low gloss.

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“…Talcum appears inert in most chemical reagents, and does not break down when contacted with acid [20]. Talcum has the low thermal conductivity and high thermal shock resistance, and still not decomposed when heated to 900 • C [21]. The excellent properties of talcum powder make it the good filler and can be used as an additive for coatings.…”

mentioning

confidence: 99%

Synergistic Effect of Addition of Fillers on Properties of Interior Waterborne UV-Curing Wood Coatings

et al. 2017

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A waterborne ultraviolet (UV)-curing coating was prepared on the surface of wood materials with modification of talcum powder and calcium carbonate (CaCO 3 ). When the waterborne UV-curing coatings on the surface of wood materials (WUVCW) was radiated for 1 min by UV (λ = 365 nm) and dried at 40 • C for 10 min, it showed good hardness, adhesion, and impact strength, with controlling the talcum content of 2.0% and CaCO 3 content of 1.0%, respectively. When the content of talcum powder was higher than 2%, the mechanical properties and gloss of the WUVCW decreased, and when the talcum powder of WUVCW increase to more than 5%, a matte surface appeared after curing. When CaCO 3 and talcum powder were present at the same time, the mechanical properties of WUVCW were better than those of only CaCO 3 or talcum powder.it is necessary to modify the WUVCW in order to improve the mechanical properties and reduce the gloss [14].Wu et al. [15] used the antimony doped tin oxide to UV curable waterborne poly(urethane-acrylate) for the modification of thermal insulation by sol-gel process. Liao et al. [16] used carbon nitride to reinforce the mechanical and thermal properties of UV-curable waterborne polyurethane acrylate coatings. Rahman et al. [17] studied nanoferrite on the anticorrosive property of waterborne epoxy-acrylate coatings. Lv et al. [18] used silica on the thermochromics property of waterborne UV-curable polyurethane acrylate nanocomposites coatings. Talcum powder has an advantage of low price, stability of the physical and chemical properties, tasteless, and non-toxic [19]. The particles have the typical scaly, which can improve the heat resistance and bending resistance of the material. Talcum appears inert in most chemical reagents, and does not break down when contacted with acid [20]. Talcum has the low thermal conductivity and high thermal shock resistance, and still not decomposed when heated to 900 • C [21]. The excellent properties of talcum powder make it the good filler and can be used as an additive for coatings. Calcium carbonate (CaCO 3 ) is the white powder that is non-toxic, tasteless, none irritating, cheap and rich in resources, and has been widely used in plastic and ink fields [22].The manuscript presented an interesting research on the optimization of the wood coatings by modifying the coating's composition in order to maximize the output quality. Used coating components are somewhat more environmentally friendly than the ones that are commonly used. In this paper, talcum powder and CaCO 3 were combined to modify the WUVCW, and compared with single use of CaCO 3 or talcum. Heating with UV curing is used in combination during this technology. The orthogonal experiment was used to select and optimize the parameters of synergistic effect of talcum and CaCO 3 . The purpose of the synergistic modification is to enhance the mechanical properties and to reduce the gloss of the WUVCW.

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Physicomechanical and physicochemical characterizations of biexponential compaction process of paracetamol in the presence of talcum-lubricated-MCC

Cited by 9 publications

References 37 publications

Quantitative Estimation of Tabletability of Aceclofenac after Incorporation of Titanium Dioxide using Area under the Curve

Quantitative Estimation of Tabletability of Aceclofenac after Incorporation of Titanium Dioxide using Area under the Curve

Effect of Single Modification of Talcum Powder on Mechanical Properties and Optical Properties of Waterborne UV Curing Coatings

Synergistic Effect of Addition of Fillers on Properties of Interior Waterborne UV-Curing Wood Coatings

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