Physik der Sprachlaute

Trendelenburg, Ferdinand

doi:10.1007/978-3-642-47352-4_10

Cited by 7 publications

(4 citation statements)

References 27 publications

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“…However, it has been established that the cardiac stimulatory effects of 5-HT are medi ated by catecholamines (7,(19)(20)(21)(22). In the present study, it was confirmed that 5-HT produced dose-relatedly positive chronotropic and inotropic effects through an adrenergic mechanism.…”

Section: Absence Of Blocking Effect Of Tetrodotoxin On the 5-ht-inducsupporting

confidence: 80%

Pharmacologic Analysis of Chronotropic and Inotropic Responses to 5-Hydroxytryptamine in the Dog Heart

Chiba

1977

Japanese Journal of Pharmacology

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Abstract-Inotropic and chronotropic effects of 5-hydroxytryptamine (5-HT) were investigated in twenty-five isolated canine atrial preparations and three isolated paced ventricular preparations which were suspended in the bath and perfused with arterial blood from the carotid artery of the heparinized support dog. 5-HT was administered into the cannulated sinus node artery in a dose range of I to 300 pig. In small doses of I to 3 pig, 5-HT induced a negative chronotropic and inotropic response.At relatively higher doses over 10 ptg, 5-HT induced a biphasic response: a slight negative chrono tropic and inotropic response, followed by a long-lasting positive response. With large doses, only a positive chronotropic and inotropic response was induced in the majority of cases. Even in the ventricular preparations, 5-HT produced a similar response pattern in inotropism.5-HT-induced positive chronotropic and inotropic responses were completely inhibited by pretreatment with an adrenergic beta-blocking agent, propranolol, or a non-depressant beta-blocking agent, carteolol, and desipra mine, but were not influenced by tetrodotoxin treatment. After the treatment with carteolol or despramine, 5-HT-induced negative responses were potentiated.5-HT induced negative chronotropic and inotropic responses were not inhibited by methy sergide and atropine.From these results, it is suggested that 5-HT induces a direct negative chronotropic and inotropic response and an indirect positive response via its tyramine-like action.5-Hydroxytryptamine (5-HT, serotonin) has positive inotropic and chronotropic effects of varying degrees on isolated hearts, atria and isolated papillary muscles of various species (1, 2). In 1964, James (3) reported that 5-HT had only a negative chronotropic effect on the canine sino-atrial (SA) node in vivo, in contrast to its reported acceleratory action in isolated heart preparations. In 1967, Buccino et al. (4) studied effects of 5-HT in cut pa pillary muscles and canine right-heart-bypass preparations with bilateral carotid sinus and vagal nerve resection. They reported that 5-HT increased the average peak tension of cat papillary muscles or dog left ventricles and concluded that 5-HT has a direct positive inotropic effect on mammalian myocardium. Such a postulation was based on the findings that the augmentation in either rate of tension developed or peak isometric tension produced by 5-HT was not accompanied by changes in time to peak tension, differing from actions of norepinephrine (5, 6). However, they did not use pharmacological drugs for the analysis of effects of 5-HT. In 1971, Fillion et al. (7) reported that when using biochemical assay techniques, release of norepinephrine from the dog heart in situ occurred after intravenous and intracoronary administration of 5-HT.In the present study, effects of 5-HT on pacemaker activity and contractility were in

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Section: Absence Of Blocking Effect Of Tetrodotoxin On the 5-ht-inducsupporting

confidence: 80%

Pharmacologic Analysis of Chronotropic and Inotropic Responses to 5-Hydroxytryptamine in the Dog Heart

Chiba

1977

Japanese Journal of Pharmacology

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“…In 1960, Trendelenburg (12) reported that chronotropic and inotropic responses to histamine by isolated atria were not effectively blocked by most of the widely used antihistamines.…”

Section: Discussionmentioning

confidence: 99%

Absence of Blocking Effect of Burimamide and Metiamide on Positive Chronotropic and Inotropic Responses to Histamine in Isolated Dog Atrium

Chiba

1977

Japanese Journal of Pharmacology

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Abstract-Whenhistamine was injected into the sinus node artery of isolated dog atrium perfused with arterial blood led from a carotid artery of the heparinized support dog, positive chronotropic and inotropic effects were dose-relatedly induced at a dose range of 0.1 to 100 Pg. The threshold dose for inducing these positive effects was approximately 0.3 ; eg. These positive responses to histamine were not blocked by tetrodotoxin, desmethylimipramine and alprenolol.These positive effects of histamine were also not significantly influenced by treatment with a histamine H2 receptor an tagonist, burimamide or metiamide.However, these histamine-induced positive chronotropic and inotropic effects were significantly suppressed by an adequate dose of histamine 1-11 receptor antagonist, tripelennamine or diphenhydramine, which enhanced the actions of norepinephrine.From these results, it is suggested that in the dog atrium, histamine causes positive chronotropic and inotropic effects via his tamine H1 receptors. (1-4). However, in isolated dog heart, there is no available report for existence of histamine H2 receptors.Thus, in the present experiments, an attempt was made to investigate the characteristics of cardiac histamine receptors in isolated dog atrium by means of the selective histamine H2 receptor blocking agents, burimamide or metiamide, using the isolated, blood-perfused atrium preparation of the dog (5, 6). Moreover, the action of histamine was analysed by use of pharmacological key drugs, i.e., histamine H1 receptor antagonists (tripelennamine and diphenhydramine), alprenolol which is a potent adrenergic beta-receptor blocking agent, desmethylimipramine which blocks uptake mechanism in the sympathetic nerve terminals, and tetrodotoxin which blocks nerve excitation. MATERIALS AND METHODSTwenty-five mongrel dogs, weighing 11-16 kg, were anesthetized with sodium pen

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“…We have found that the 5-HT-induced tachycardia was markedly antagonized by propranolol (Feniuk & Humphrey, unpublished observation) and was reduced by bilateral adrenalectomy and pretreatment with syrosingopine (this study). However, since catecholamine depletion did not completely abolish the chronotropic effect of 5-HT, it may be that its action involves both a direct and an indirect component (see Trendelenburg 1960). The direct effect of 5-HT may involve a specific 5-HT receptor which appears to be present in the atria of some species (Schneider & Yonkman 1954;Trendelenburg 1960;Gonzales & Garcia 1977).…”

Section: Effect Of Acute Bilateral Adrenalectomymentioning

confidence: 99%

An analysis of the mechanism of 5-hydroxytrypt-amine-induced vasopressor responses in ganglion-blocked anaesthetized dogs

Feniuk

Hare

Humphrey

1981

Journal of Pharmacy and Pharmacology

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5‐Hydroxytryptamine (5‐HT) administered intravenously (i.v., 1–30 μg kg−1) to ganglion‐blocked anaesthetized dogs produced dose‐related increases in diastolic blood pressure and we have analysed the mechanism involved. Cyproheptadine and methysergide (10–100 μg kg−1 i.v.) were potent and specific antagonists of the 5‐HT induced rise in blood pressure, while the α‐adrenoceptor blocking agent phentolamine (0·3–3 mg kg−1 i.v.) also caused dose‐related inhibition. Syrosingopine pretreatment converted the vasopressor action of 5‐HT to a vasodepressor action and acute bilateral adrenalectomy caused a marked reduction in the 5‐HT‐induced rise in blood pressure. In two dogs, 5‐HT (30 μg kg−1 i.v.) markedly increased the venous plasma concentrations of noradrenaline and adrenaline. We concluded that the 5‐HT‐induced rise in diastolic pressure in the ganglion blocked anaesthetized dog is due largely to the release of catecholamines of which a substantial component is from the adrenal gland. The rise in diastolic blood pressure is specifically blocked by low doses of cyproheptadine and methysergide suggesting that the release of catecholamines is mediated by specific 5‐HT receptors located mainly within the adrenal medulla.

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Physik der Sprachlaute

Cited by 7 publications

References 27 publications

Pharmacologic Analysis of Chronotropic and Inotropic Responses to 5-Hydroxytryptamine in the Dog Heart

Pharmacologic Analysis of Chronotropic and Inotropic Responses to 5-Hydroxytryptamine in the Dog Heart

Absence of Blocking Effect of Burimamide and Metiamide on Positive Chronotropic and Inotropic Responses to Histamine in Isolated Dog Atrium

An analysis of the mechanism of 5-hydroxytrypt-amine-induced vasopressor responses in ganglion-blocked anaesthetized dogs

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