Physiologic actions of heparin not related to blood clotting

Dougherty, Thomas F.; Dolowitz, David A.

doi:10.1016/0002-9149(64)90099-2

Cited by 52 publications

(15 citation statements)

References 12 publications

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“…First, an inhibition of the immunologic reactions by azathioprine would to some degree decrease the consumption of complement and allow increased hemolytic complement activity in serum. Second, dissolution of antigen antibody complexes by heparin [8,31] would greatly decrease the utilization of all of the complement components. Third, it has been shown that the clotting mechanism can activate the complement cascade [39]: in those patients in whom significant intra vascular coagulation is occurring, heparin could decrease the utilization of complement by its anticoagulant effect.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Azathioprine, Prednisone, and Heparin Alone or Combined in Treating Lupus nephritis

Cade

Spooner

Schlein

et al. 1973

Nephron

139

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50 patients with proliferative glomerulonephritis due to lupus erythematosus were assigned in order of their chronologic appearance at the hospital alternately to treatment with either daily high dose prednisone, azathioprine, prednisone and azathioprine combined, or combined azathioprine and heparin. Prednisone alone was ineffective both from a standpoint of maintaining kidney function or from preserving a state of well being. Only 2 of 15 patients treated with prednisone are doing well with an average survival for the group of 19 months. Azathioprine, alone, appeared very effective with 9 of 13 patients alive and doing well with an average survival of 38 months. Combinations of either azathioprine and prednisone or azathioprine and heparin were most successful, only 2 of 13 in each group died of renal failure. Complications of prednisone administra’ion were high both when prednisone was given alone or in combination with azathioprine.

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Section: Discussionmentioning

confidence: 99%

Comparison of Azathioprine, Prednisone, and Heparin Alone or Combined in Treating Lupus nephritis

Cade

Spooner

Schlein

et al. 1973

Nephron

139

View full text Add to dashboard Cite

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“…Also the marked improvement in renal function noted in this case is unusual for the type of glomerular lesion present on the patient's initial biopsy. Heparin, in addition to its anticoagulant properties, also is anticomplimentary [4,14]. This patient, on admission, had a normal serum complement which de creased after starting heparin.…”

Section: Discussionmentioning

confidence: 87%

Wegener’s Granulomatosis Treatment with Heparin in Addition to Azathioprine and Corticosteroids

Fuller¹,

Olsen²,

Block³

et al. 1972

Nephron

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A case of Wegener’s granulomatosis in a 51-year-old white male is described. His initial clinical course was characterized by severe renal and pulmonary insufficiency. Renal biopsy showed severe proliferative glomerulonephritis with crescent formation plus intraglomerular fibrin deposition. Because of the seriousness of the renal lesion along with the demonstrated fibrin deposition, the patient was treated with heparin in addition to azathioprine and methylprednisolone. A prompt improvement in renal function was noted following heparin administration. After 9 months, heparin was stopped while azathioprine and prednisolone were continued. Renal function deteriorated and then improved after reinstitution of heparin therapy. The initial chest roentgenogram and pulmonary function tests were compatible with Goodpasture’s syndrome. Nine months later, however, the more classic picture of basilar cavitary lesions appeared.

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“…[6,7]), unter anderem in der Behandlung von Ekzemen [8]. Heparin hat histaminbindende Effekte und trägt auch dadurch zur Bekämpfung von Juckreiz bei [9]. Die Wirksamkeit einer Cremezubereitung mit der Wirkstoffkombination Levomenol + Heparin in der Abheilung von atopischen Ekzemen und Pruritus wurde in einer randomisierten Doppelblindstudie gegen die wirkstofffreie Cremebasis belegt [10].…”

Section: Originalarbeit 217unclassified