Physiologic Basis of Pulmonary Edema during Intestinal Reperfusion

Iglesias, J.; LaNoue, John L.; Rogers, Thomas E.; Inman, Lindsay; Turnage, Richard H.

doi:10.1006/jsre.1998.5435

Cited by 34 publications

(24 citation statements)

References 28 publications

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“…Mesenteric I/R injury has been reported to induce acute lung injury characterized by increased neut- rophil and cytokine activation and also accumulation of inflammatory infiltrates, alveolar capillary endothelial cell injury, increased microvascular permeability, and pulmonary edema (21). In this study, supporting the previous studies, histopathological scores of lung tissues showed correlation with intestinal injury.…”

Section: Resultssupporting

confidence: 90%

The protective effects of curcumin on intestine and remote organs against mesenteric ischemia/reperfusion injury

Önder¹,

Kapan²,

Gümüş³

et al. 2012

Turk J Gastroenterol

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Section: Resultssupporting

confidence: 90%

The protective effects of curcumin on intestine and remote organs against mesenteric ischemia/reperfusion injury

Önder¹,

Kapan²,

Gümüş³

et al. 2012

Turk J Gastroenterol

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“…In this study, reperfusion without hIL-10 overexpression after 60 min of mesenteric ischemia led to neutrophil accumulation and increased MPO activity, which is consistent with previous studies (Iglesias et al 1998;Koksoy et al 2000). We measured neutrophil accumulation both by determining MPO concentration within the lung and histopathological counting.…”

Section: Discussionsupporting

confidence: 91%

“…There are several methods to evaluate the degree of pulmonary edema in literature (Iglesias et al 1998;Koike et al 2000;Koksoy et al 2001;Dowdall et al 2002). Lung tissue wet/dry ratio and Evans blue dye concentration were used in the current study to assess the changes in the pulmonary microvascular permeability.…”

Section: Discussionmentioning

confidence: 99%

Interleukin-10 Gene Therapy Attenuates Pulmonary Tissue Injury Caused by Mesenteric Ischemia-Reperfusion in a Mouse Model

Kabay

Aytekin

Aydın

et al. 2005

Tohoku J. Exp. Med.

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“…Ultimately, multi-organ failure ensues and involves the liver [18] , heart [26] , kidneys [27] and lungs [28] . Acute pulmonary edema resulting from mesenteric ischemia/reperfusion is caused by an increase in pulmonary microvascular permeability to fluids and proteins, as well as smooth muscle dysfunction [29,30] .…”

Section: Pathophysiologymentioning

confidence: 99%

Acute mesenteric ischemia after cardio-pulmonary bypass surgery

Abboud¹,

Daher²,

Boujaoude³

2008

WJG

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Acute mesenteric ischemia (AMI) is a highly-lethal surgical emergency. Several pathophysiologic events (arterial obstruction, venous thrombosis and diffuse vasospasm) lead to a sudden decrease in mesenteric blood flow. Ischemia/reperfusion syndrome of the intestine is responsible for systemic abnormalities, leading to multi-organ failure and death. Early diagnosis is difficult because the clinical presentation is subtle, and the biological and radiological diagnostic tools lack sensitivity and specificity. Therapeutic options vary from conservative resuscitation, medical treatment, endovascular techniques and surgical resection and revascularization. A high index of suspicion is required for diagnosis, and prompt treatment is the only hope of reducing the mortality rate. Studies are in progress to provide more accurate diagnostic tools for early diagnosis. AMI can complicate the post-operative course of patients following cardio-pulmonary bypass (CPB). Several factors contribute to the systemic hypo-perfusion state, which is the most frequent pathophysiologic event. In this particular setting, the clinical presentation of AMI can be misleading, while the laboratory and radiological diagnostic tests often produce inconclusive results. The management strategies are controversial, but early treatment is critical for saving lives. Based on the experience of our team, we consider prompt exploratory laparotomy, irrespective of the results of the diagnostic tests, is the only way to provide objective assessment and adequate treatment, leading to dramatic reduction in the mortality rate.

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Physiologic Basis of Pulmonary Edema during Intestinal Reperfusion

Cited by 34 publications

References 28 publications

The protective effects of curcumin on intestine and remote organs against mesenteric ischemia/reperfusion injury

The protective effects of curcumin on intestine and remote organs against mesenteric ischemia/reperfusion injury

Interleukin-10 Gene Therapy Attenuates Pulmonary Tissue Injury Caused by Mesenteric Ischemia-Reperfusion in a Mouse Model

Acute mesenteric ischemia after cardio-pulmonary bypass surgery

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