Physiologic Effects of Multiple Pregnancy on Mother and Fetus

Amorosa, Jennifer; Cleary-Goldman, Jane; D’Alton, Mary E.

doi:10.1016/b978-0-323-35214-7.00016-0

Cited by 2 publications

(2 citation statements)

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“…Increased risk for complications such as growth abnormalities, preterm birth, and neurological deficits are seen with multiple births (Amorosa et al, 2017). Studies suggest increased vulnerability of male fetuses to prenatal insults, for example, gestational stress, maternal infection, and drug exposure, affecting the male's health long-term (Bale et al, 2010;DiPietro & Voegtline, 2017).…”

Section: Discussionmentioning

confidence: 99%

“…Previous results showed that same‐sex female twins have the highest risk of disordered eating, followed by opposite‐sex female twins, opposite‐sex male twins and lastly, the lowest risk was seen for same‐sex male twins (Culbert et al, 2008). Increased risk for complications such as growth abnormalities, preterm birth, and neurological deficits are seen with multiple births (Amorosa et al, 2017). Studies suggest increased vulnerability of male fetuses to prenatal insults, for example, gestational stress, maternal infection, and drug exposure, affecting the male's health long‐term (Bale et al, 2010; DiPietro & Voegtline, 2017).…”

Section: Discussionmentioning

confidence: 99%

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Exposures during pregnancy and at birth are associated with the risk of offspring eating disorders

Ozsvar,

Gissler,

Lavebratt

et al. 2023

Intl J Eating Disorders

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BackgroundEating disorders (ED) are severe psychiatric disorders, commonly debuting early. Aberrances in the intrauterine environment and at birth have been associated with risk of ED. Here, we explore if, and at what effect size, a variety of such exposures associate with offspring ED, that is, anorexia nervosa (AN), bulimia nervosa (BN), and eating disorder not otherwise specified (EDNOS).MethodsThis population‐based cohort study, conducted from September 2021 to August 2023, used Finnish national registries of all live births in 1996–2014 (N = 1,097,753). Cox proportional hazards modeling was used to compare ED risk in exposed versus unexposed offspring, adjusting for potential confounders and performing sex‐stratified analyses.ResultsA total of 6614 offspring were diagnosed with an ED; 3668 AN, 666 BN, and 4248 EDNOS. Lower risk of offspring AN was seen with young mothers, continued smoking, and instrumental delivery, while higher risk was seen with older mothers, inflammatory disorders, prematurity, small for gestational age, and low Apgar. Offspring risk of BN was higher with continued smoking and prematurity, while lower with postmature birth. Offspring risk of EDNOS was lower with instrumental delivery, higher for older mothers, polycystic ovary syndrome, insulin‐treated pregestational diabetes, antibacterial treatment, prematurity, and small for gestational age. Sex‐specific associations were found.ConclusionsSeveral prenatal and at birth exposures are associated with offspring ED; however, we cannot exclude confounding by maternal BMI. Nevertheless, several exposures selectively associate with risk of either AN, BN, or EDNOS, and some are sex‐specific, emphasizing the importance of subtype‐ and sex‐stratified analyses of ED.Public SignificanceWe define environmental factors involved in the development of different ED, of importance as preventive measure, but also in order to aid in defining the molecular pathways involved and thus in the longer perspective contribute to the development of pharmacological treatment of ED.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Exposures during pregnancy and at birth are associated with the risk of offspring eating disorders

Ozsvar,

Gissler,

Lavebratt

et al. 2023

Intl J Eating Disorders

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Not only pregnancy but also the number of fetuses in the uterus affects intraocular pressure

Saylik

Saylık

2014

Indian J Ophthalmol

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Aim:To investigate whether, intraocular pressure (IOP) is affected when there is a second fetus in the uterus during pregnancy.Materials and Methods:Eighty eyes of 40 twin pregnancies (TwPs), 80 eyes of 40 singleton pregnancies (SiPs) and 80 eyes of 40 non-pregnant females (NoPs) were included in the study.Statistical Analysis:Repeated measurements analysis of variance with two factors, one-way analysis of variance (ANOVA) and theTukey's multiple comparison test were used.Results:The mean IOP (MIOP) values in TwPs were 14.29 ± 1.28, 11.48 ± 1.20, and 9.81 ± 1.36 mmHg and the MIOP values in SiPs were 14.42 ± 0.95, 13.12 ± 0.75, and 10.97 ± 0.89 mmHg in subsequent trimesters. The MIOP values in NoPs were 14.77 ± 1.18, 14.92 ± 1.33, and 15.08 ± 0.89 mmHg in subsequent 3-month measurements. The results show that the MIOP values for the TwPs group were significantly lower than the SiPs in all trimesters.Conclusions:During pregnancy, the number of fetuses in the uterus is an indirectly important factor that influences the decrease in IOP. We hypothesize that the increased ocular hypotensive effect of TwPs is most likely related to the presence of higher levels of hormones, particularly estrogen, progesterone and relaxin compared with SiPs.

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Physiologic Effects of Multiple Pregnancy on Mother and Fetus

Cited by 2 publications

References 74 publications

Exposures during pregnancy and at birth are associated with the risk of offspring eating disorders

Exposures during pregnancy and at birth are associated with the risk of offspring eating disorders

Not only pregnancy but also the number of fetuses in the uterus affects intraocular pressure

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