Physiologic Principles of Coronary Perfusion

Shaw, Robert F.; Mosher, Paul; Ross, John; Joseph, Julian I.; Lee, Arnold S.J.; Humphreys, George H.

doi:10.1016/s0022-5223(19)32925-3

Cited by 70 publications

(6 citation statements)

References 4 publications

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“…Myocardial blood flow (MBF) must respond to changes in metabolic conditions and oxygen requests to meet the needs of myocytes and autoregulation plays a mayor role in the control of coronary circulation [1][2][3]. It has been demonstrated that as coronary artery was progressively narrowed, resting flow did not change at first, but maximal flow (achieved by injecting a vasodilator) decreased progressively [4,5].…”

Section: Reviewmentioning

confidence: 99%

Imaging techniques for assessment of coronary flow reserve

Petretta

Acampa²,

Zampella³

et al. 2015

Monaldi Arch Chest Dis

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The assessment of coronary flow reserve (CFR) may be useful for the functional evaluation of coronary artery disease (CAD). Invasive techniques, such as intracoronary Doppler ultrasound and pressure-derived method, directly assess CFR velocity and fractional flow reserve. Positron emission tomography (PET) has emerged as an accurate noninvasive technique to quantify CFR. Nevertheless, this approach has not been applied to routine studies because of its high cost and complexity. Recently, attempts to estimate CFR with single-photon emission computed tomography (SPECT) tracers have been made in order to obtain, with noninvasive methods, data for quantitative functional assessment of CAD. This review analyzes the relative merit and limitations of CFR measurements by cardiac imaging techniques and describes the potential clinical applications.

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Section: Reviewmentioning

confidence: 99%

Imaging techniques for assessment of coronary flow reserve

Petretta

Acampa²,

Zampella³

et al. 2015

Monaldi Arch Chest Dis

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…”

mentioning

confidence: 99%

Imaging Techniques for the Assessment of Coronary Flow Reserve

Petretta¹,

Costanzo²,

Cuocolo³

2008

European Cardiology Review

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Myocardial blood flow (MBF) must respond to changes in metabolic conditions and oxygen requests to meet the needs of myocytes, and autoregulation plays a mayor role in the control of coronary circulation. [1][2][3] It has been demonstrated that, as a coronary artery is progressively narrowed, resting flow does not change at first, but maximal flow (achieved by injecting a vasodilator) decreases progressively. 4,5 Coronary flow reserve (CFR) is the term used to describe the amount of additional blood flow that can be supplied to the heart above baseline blood flow. The absence of CFR implies maximal vasodilatation of the resistance vessels at rest and an inability to further increase MBF.Different terms are used to describe CFR. 6,7 Absolute flow reserve is the ratio of blood flow in a stenotic artery during maximal hyperaemia to blood flow in the same artery under resting conditions. 8,9 The invasive Doppler-based technique, which measures coronary blood velocity at rest and during hyperaemia, and positron emission tomography (PET), which measures absolute MBF at rest and during hyperaemia, are good examples of absolute CFR measurements. Relative flow reserve is the ratio of hyperaemic flow in a stenotic artery to hyperaemic flow in a normal artery. 10,11 Myocardial perfusion imaging by single-photon-emission computed tomography (SPECT) is based on this concept of demonstrating ischaemia and identifying significant coronary artery stenosis. Fractional flow reserve (FFR) is a term used to describe the ratio of the maximum achievable flow in the presence of a stenosis to the theoretical maximum flow in the same artery if it were normal. 12,13 This is the basis of the pressurederived method that is the invasive method of choice for determining the significance of a stenosis of moderate severity. 14 It must be noted that several factors influence CFR measurement, including the ability to achieve maximal coronary vasodilatation, heart rate and myocardial contractility, right atrial pressure, serial coronary stenosis, coronary resistance and coronary collateral circulation. 15-21 Each of these factors has a different impact according to the method used for CFR evaluation.

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“…Κάτω από φυσιολογικές συνθήκες η ροή του αίματος στα στεφανιαία ρυθμίζεται από μόνη της, αρκεί η πίεση αιμάτωσής τους να κυμαίνεται από 70 μέχρι 145 mmHg (25,231). ανεξάρτητα από το αν η καρδιά έχει φυσιολογική ή όχι νεύ ρωση.…”

Section: φυσιολογια της κυκλοφοριας του αιματος στα στεφανιαιαunclassified

Η Πληρης Επαναιματωση Του Μυοκαρδιου Με Αορτοστεφανιαια Παρακαμπτηρια Μοσχευματα Στην Αντιμετωπιση Της Στεφανιαιας Νοσου

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Physiologic Principles of Coronary Perfusion

Cited by 70 publications

References 4 publications

Imaging techniques for assessment of coronary flow reserve

Imaging techniques for assessment of coronary flow reserve

Imaging Techniques for the Assessment of Coronary Flow Reserve

Η Πληρης Επαναιματωση Του Μυοκαρδιου Με Αορτοστεφανιαια Παρακαμπτηρια Μοσχευματα Στην Αντιμετωπιση Της Στεφανιαιας Νοσου

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