Physiologic Reactivity to a Laboratory Stress Task Among Men with Benign Prostatic Hyperplasia

Ullrich, Philip M.; Lutgendorf, Susan K.; Kreder, Karl J.

doi:10.1016/j.urology.2007.04.048

Cited by 33 publications

(20 citation statements)

References 24 publications

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“…The relationship between the metabolic syndrome and LUTS may be based on the fact that the metabolic syndrome is associated with an overactivity of autonomic nervous system (Bjorntorp & Rosmond, 2000; Kasturi et al. , 2006; Ullrich et al. , 2007).…”

Section: Discussionmentioning

confidence: 99%

“…A recent study provided supporting evidence that stress conditions could be associated with the development and aggravation of prostatic disease. It was found that body mass index (BMI), age and greater diastolic blood pressure reactivity correlated with a greater transition zone volume, greater total prostate gland volume, greater post‐void residual bladder volume (RBV) and more severe LUTS (Ullrich et al. , 2007).…”

Section: Introductionmentioning

confidence: 99%

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Concurrent improvement of the metabolic syndrome and lower urinary tract symptoms upon normalisation of plasma testosterone levels in hypogonadal elderly men

Haider¹,

Gooren

Padungtod

et al. 2009

Andrologia

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Central obesity in adulthood, the metabolic syndrome, erectile failure and lower urinary tract symptoms (LUTS) are all associated with lower-than-normal testosterone levels, although the relationship between testosterone and LUTS appears weak. The metabolic syndrome is associated with an overactivity of the autonomic nervous system. Alternatively, the metabolic syndrome is associated with markers of inflammation, such as C-reactive protein (CRP), maybe signalling intraprostatic inflammation. A large cohort of 95 middle-aged to elderly hypogonadal men (T levels 5.9-12.1 nmol l(-1)) were treated with parenteral testosterone undecanoate and its effects on the metabolic syndrome {waist circumference, cholesterol, CRP and LUTS [residual bladder volume (RBV), International Prostate Symptoms Score (IPSS), prostate volume, prostate-specific antigen (PSA)]} were evaluated. Along with the improvements of the metabolic syndrome, there was a significant decline of the values of the IPSS, RBV and CRP. There was a (low) level of correlation between the decline of waist circumference and residual volume of urine but not with IPSS and prostate size. Along with the improvement of the metabolic syndrome upon testosterone administration, there was also an improvement of the IPSS and of RBV of urine and CRP. The mechanism remains to be elucidated.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Concurrent improvement of the metabolic syndrome and lower urinary tract symptoms upon normalisation of plasma testosterone levels in hypogonadal elderly men

Haider¹,

Gooren

Padungtod

et al. 2009

Andrologia

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“…Physiologic responses to a standardized laboratory stressor has also been associated with objective and subjective BPH disease parameters [9] .…”

Section: Introductionmentioning

confidence: 99%

Sympathetic Nervous System Overactivity in the Wistar Rat with Proliferative Lesions of Ventral Prostate Induced by Chronic Stress

Huang

Fang²,

Meng³

et al. 2009

Urol Int

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Objectives: The sympathetic nervous system and hypothalamic-pituitary-adrenal axis have been known to be reactive to psychological factors such as stress in which several humoral factors are released. Growing data suggest that stress conditions could be associated with the development or aggravation of prostatic disease. The present study aims to investigate the influence of chronic stress and blockade of the sympathetic nerve on rat prostate. Methods: We used 2 weeks of restraint water-immersion stress to induce a chronic psychological stress model of Wistar rats. Denervation of the peripheral sympathetic nerve was done by 6-hydroxydopamine (6-OHDA). Blood flow of ventral prostate, plasma catecholamine and cortisol were measured at the end of the experiment. The weight and secretions of dissected prostate lobes were measured and histology was performed by hematoxylin and eosin stain. Results: After 14 days of stress, the blood flow of ventral prostate decreased and plasma cortisol increased. The apparent proliferation of epithelium of ventral lobes were observed and dorsolateral ones were almost unaffected. On the other hand, the hyperplasia changes were not seen after the chemical sympathectomy had been done during stress. Conclusions: Chronic stress may lead to hyperplasia of ventral prostate, the overactivity of sympathetic nervous system is involved in the pathogenesis of prostatic disease.

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“…Studies examining associations between physiologic measures of the ANS and LUTS are limited, but a few studies suggest that ANS activity may be associated with LUTS [5, 6]. However, the tests used in these studies were not specific for α -adrenergic or muscarinic acetylcholine function, making it difficult to determine whether specific ANS components are important in the development of LUTS.…”

mentioning

confidence: 99%

“…McVary et al [5] found associations between elevated urinary catecholamines, blood pressure readings, and heart rate measures following tilt-table testing and LUTS, prostate volume, and bother due to LUTS. Ullrich et al [6] also found associations between increases in diastolic blood pressure and cortisol following a laboratory stress test and prostate enlargement and LUTS. More recently, Choi et al [10] found that men with LUTS had lower measures of parasympathetic function compared to unaffected men.…”

mentioning

confidence: 99%

Measures of autonomic nervous system activity and lower urinary tract symptoms

et al. 2010

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Autonomic nervous system (ANS) activity may play an important role in the development of lower urinary tract symptoms (LUTS). Men with severe LUTS and men with mild or no LUTS completed the Valsalva maneuver, quantitative sudomotor axon reflex test, tilt-table, and deep breathing tests. There were no differences between men with severe LUTS compared to men with mild or no LUTS (all P values > 0.05). Systemic ANS tests may not be useful in detecting the underlying physiologic changes that lead to LUTS in aging men.

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Physiologic Reactivity to a Laboratory Stress Task Among Men with Benign Prostatic Hyperplasia

Cited by 33 publications

References 24 publications

Concurrent improvement of the metabolic syndrome and lower urinary tract symptoms upon normalisation of plasma testosterone levels in hypogonadal elderly men

Concurrent improvement of the metabolic syndrome and lower urinary tract symptoms upon normalisation of plasma testosterone levels in hypogonadal elderly men

Sympathetic Nervous System Overactivity in the Wistar Rat with Proliferative Lesions of Ventral Prostate Induced by Chronic Stress

Measures of autonomic nervous system activity and lower urinary tract symptoms

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