Physiological 18F-FDG uptake in the normal adult anal canal: evaluation by PET/CT

Sena, Yankel; Matsumoto, Shunro; Silman, Christopher; Otsuka, Kenichiro; Kiyota, Takashige

doi:10.1007/s12149-020-01480-9

Cited by 7 publications

(5 citation statements)

References 16 publications

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“…In one study which involved the retrospective analysis of PET/CT scans to determine FDG uptake in the anal canal of 201 healthy patients, 15.4% of patients demonstrated high FDG uptake in the anal canal during the early phase of imaging. The average anal SUV max in the early phase was 3.82 for these patients, significantly lower than the average for anal cancer patients [19]. Another study compared the SUV max of the anal canal in patients with and without hemorrhoids and discovered a mean SUV max of 2.9 (range: 1.4-8.3) in patients with hemorrhoids [8].…”

Section: Discussionmentioning

confidence: 99%

Quantifying¹⁸F-Fluorodeoxyglucose Uptake in Perianal Fistulas on PET/CT: A Retrospective Analysis

Huang,

Garuba,

Ganapathy

et al. 2023

Preprint

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Rationale and ObjectivesThe use of18F-fluorodeoxyglucose positron emission tomography-computed tomography (FDG-PET/CT) in assessing inflammatory diseases has shown significant promise. Uptake patterns in perianal fistulas, which may be an incidental finding on PET/CT, have not been purposefully studied. Our aim was to compare FDG uptake of perianal fistulas to that of the liver and anal canal in patients who underwent PET/CT for hematologic/oncologic diagnosis or staging.Materials and MethodsWe retrospectively identified patients who underwent FDG- PET/CT imaging between January 2011 and May 2023, where the report described a perianal fistula or abscess. PET/CTs of patients included in the study were retrospectively analyzed to record the maximum standardized uptake value (SUVmax) of the fistula, abscess, anal canal, rectum, and liver. Fistula-to-liver and Fistula-to-anus SUVmaxratios were calculated. We statistically compared FDG activity among the fistula, liver, and anal canal. We also assessed FDG activity in patients with vs. without anorectal cancer, as well as across different St. James fistula grades.ResultsThe study included 24 patients with identifiable fistulas. Fistula SUVmax(mean=10.8±5.28) was significantly higher than both the liver (mean=3.09±0.584, p<0.0001) and the anal canal (mean=5.98± 2.63, p=0.0005). Abscess fistula SUVmaxwas 15.8 ± 4.91. St. James grade 1 fistulas had significantly lower SUVmaxcompared to grades 2 and 4 (p= 0.0224 and p=0.0295 respectively). No significant differences existed in SUVmaxratios between anorectal and non-anorectal cancer groups.ConclusionPerianal fistulas have increased FDG avidity with fistula SUVmaxvalues that are significantly higher than the anal canal.

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Section: Discussionmentioning

confidence: 99%

Quantifying¹⁸F-Fluorodeoxyglucose Uptake in Perianal Fistulas on PET/CT: A Retrospective Analysis

Huang,

Garuba,

Ganapathy

et al. 2023

Preprint

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“…When high anal carcinoma extends into the lower rectum, the pattern of spread may be more in keeping with that of rectal cancer than anal carcinoma, with intrapelvic nodes and lung metastases ( Figure 40 ). Perianal infections ( Figure 41 ), inflammatory bowel disease, inflamed hemorrhoids ( Figure 42 ) and even normal anal sphincter muscles ( Figure 43 ) may be confused with pathologic processes [ 106 ]. However, FDG PET-CT remains an important imaging modality in the management of patients with anal carcinoma.…”

Section: Anal Carcinomamentioning

confidence: 99%

PET-CT in Clinical Adult Oncology: III. Gastrointestinal Malignancies

Koppula

Fine

Salem

et al. 2022

Cancers

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PET-CT is an advanced imaging modality with many oncologic applications, including staging, assessment of response to therapy, restaging and longitudinal surveillance for recurrence. The goal of this series of six review articles is to provide practical information to providers and imaging professionals regarding the best use of PET-CT for specific oncologic indications, and the potential pitfalls and nuances that characterize these applications. In the third of these review articles, key tumor-specific clinical information and representative PET-CT images are provided to outline the role that PET-CT plays in the management of patients with gastrointestinal malignancies. The focus is on the use of 18F fluorodeoxyglucose (FDG), rather than on research radiopharmaceuticals under development. Many different types of gastrointestinal tumors exist, both pediatric and adult. A discussion of the role of FDG PET-CT for all of these is beyond the scope of this review. Rather, this article focuses on the most common adult gastrointestinal malignancies that may be encountered in clinical practice. The information provided here will provide information outlining the appropriate role of PET-CT in the clinical management of patients with gastrointestinal malignancies for healthcare professionals caring for adult cancer patients. It also addresses the nuances and provides interpretive guidance related to PET-CT for imaging providers, including radiologists, nuclear medicine physicians and their trainees.

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“…[18]F-fluorodeoxyglucose (FDG) positrone emission tomography/computed tomography (PET/CT) is a functional imaging technique with extensive use in oncology for staging, as well as for assessment of cancer relapse and response to therapy [ 16 , 17 , 18 ], but also in different non-oncological diseases related to infection and inflammation. Interestingly, recent studies have also shown that [18]F-FDG PET/CT may be useful for detecting benign bowel inflammatory activity [ 19 , 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

The Relationship among Bowel [18]F-FDG PET Uptake, Pathological Complete Response, and Eating Habits in Breast Cancer Patients Undergoing Neoadjuvant Chemotherapy

et al. 2023

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Recently, the impact of patients’ eating habits on both breast cancer (BC) management and inflammation have been proven. Here, we investigated whether inflammatory habits could correlate with baseline bowel [18]F-fluorodeoxyglucose (FDG) uptake and the latter, in turn, with pathological Complete Response (pCR) to neoadjuvant chemotherapy (NAC). We included stage I–III BC undergoing standard NAC at IRCCS Humanitas Research Hospital, Italy. Patients fulfilled a survey concerning eating/lifestyle behaviors and performed a staging [18]F-FDG positrone emission tomography/computed tomography (PET/CT). In the absence of data on the effects of individual foods, we aggregated drink and food intake for their known inflammatory properties. Data were recorded for 82 women (median age, 48). We found positive correlations between colon mean standardized uptake value (SUVmean) and pro-inflammatory drinks (alcohol and spirits; r = +0.33, p < 0.01) and foods (red and cured meats; r = +0.25, p = 0.04), and a significant negative correlation between rectum SUVmean and anti-inflammatory foods (fruits and vegetables; r = −0.23, p = 0.04). Furthermore, colon SUVmean was significantly lower in patients with pCR compared to non pCR (p = 0.02). Our study showed, for the first time, that patients’ eating habits affected bowel [18]F-FDG uptake and that colon SUVmean correlated with pCR, suggesting that PET scan could be an instrument for identifying patients presenting unhealthy behaviors.

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Physiological 18F-FDG uptake in the normal adult anal canal: evaluation by PET/CT

Cited by 7 publications

References 16 publications

Quantifying¹⁸F-Fluorodeoxyglucose Uptake in Perianal Fistulas on PET/CT: A Retrospective Analysis

Quantifying¹⁸F-Fluorodeoxyglucose Uptake in Perianal Fistulas on PET/CT: A Retrospective Analysis

PET-CT in Clinical Adult Oncology: III. Gastrointestinal Malignancies

The Relationship among Bowel [18]F-FDG PET Uptake, Pathological Complete Response, and Eating Habits in Breast Cancer Patients Undergoing Neoadjuvant Chemotherapy

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Physiological 18F-FDG uptake in the normal adult anal canal: evaluation by PET/CT

Cited by 7 publications

References 16 publications

Quantifying18F-Fluorodeoxyglucose Uptake in Perianal Fistulas on PET/CT: A Retrospective Analysis

Quantifying18F-Fluorodeoxyglucose Uptake in Perianal Fistulas on PET/CT: A Retrospective Analysis

PET-CT in Clinical Adult Oncology: III. Gastrointestinal Malignancies

The Relationship among Bowel [18]F-FDG PET Uptake, Pathological Complete Response, and Eating Habits in Breast Cancer Patients Undergoing Neoadjuvant Chemotherapy

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Quantifying¹⁸F-Fluorodeoxyglucose Uptake in Perianal Fistulas on PET/CT: A Retrospective Analysis

Quantifying¹⁸F-Fluorodeoxyglucose Uptake in Perianal Fistulas on PET/CT: A Retrospective Analysis