Physiological Action of Acetic Acid in Living Tissues

Barcroft, Joseph; McAnally, Rachel Anne; Phillipson, A. T.

doi:10.1038/151304a0

Cited by 21 publications

(26 citation statements)

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“…According to our and to Ash's results we assume that the low concentration of VFA normally found in the abomasum is mainly due to the fast absorption of acetic acid, propionic acid and butyric acid from the abomasum and less due to an absorption from the omasum, as has been postulated so far. Barcroft et al [1944] did not find an arteriovenous difference of the VFA concentrations in the abomasal blood and concluded that there was no absorption of VFA from the abomasum. Nevertheless, these results can be brought into accordance with our results.…”

Section: Discussionmentioning

confidence: 99%

Absorption of Volatile Fatty Acids, Tritiated Water and Antipyrine From the Abomasum of Goats

1968

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In conscious goats the abomasum was isolated temporarily from the rest of the gastro-intestinal tract by means of balloons, or a double by-pass or a snare around the pylorus. Abomasal contents, rumen fluid or a saline solution were given into the abomasum. Altogether forty experiments were done on four goats.The absorption of acetic acid, propionic acid, butyric acid, tritiated water (HTO) and antipyrine (AP) from the abomasum was measured. For comparison of the absorption rates, the data were given as clearance of the abomasal fluid and as water (liffusion.At a mean abomasal fluid volume of 606 ± 201 ml., 513 ± 169 ml. water diffused out of the abomasum through the abomasal mucosa per hour. The antipyrine clearance was 214 ± 84 ml./hr. The volatile fatty acids (VFA) were absorbed considerably faster at acid than at neutral pH values; at pH 5-2 -5-6 the VFA clearance was only 320 ml./hr.: at pH 3-5-4-0, however, it increased to 1130 ml./hr.The olive oil: water partition coefficients for acetic, propionic and butyric acid were measured in the pH range of 3-5 -6-2. With decreasing pH values the degree of dissociation of the acids decreases and the lipid solubility increases considerably.The permeability of the abomasal and ruminal mucosa for VFA also increases at lower pH values, but not as much as the olive oil: water partition coefficients of the acids.Absorption of VFA, HTO and AP from the abomasum is discussed in relation to the absorption of these substances from the rumen and the human stomach.

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Section: Discussionmentioning

confidence: 99%

Absorption of Volatile Fatty Acids, Tritiated Water and Antipyrine From the Abomasum of Goats

1968

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“…Large quantities of volatile fatty acids, particularly acetic acid, propionic acid and butyric acid, are produced in the rumen by microbial fermentation of dietary carbohydrates and protein and are absorbed into the bloodstream mainly through the rumen wall (Barcroft, McAnally & Phillipson, 1944). The quantitative importance of the individual volatile fatty acids as contributors to the total metabolism of the whole animal has therefore been the subject of considerable interest and investigation (Pfander & Phillipson, 1953;Schambye, 1955;Armstrong, Blaxter & Graham, 1957;Annison & Lindsay, 1961, 1962Bensadoun, Paladines & Reid, 1962;Bergman & Kon, 1964b;Lindsay & Ford, 1964).…”

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confidence: 99%

Interconversions and production of volatile fatty acids in the sheep rumen

Bergman¹,

Reid²,

Murray³

et al. 1965

Biochemical Journal

135

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1. Sheep fed at a constant rate were infused intraruminally with [1-14C]-acetate, -propionate or -butyrate during 5hr. periods. 2. Volatile fatty acids were estimated in the rumen contents and steady-state conditions were obtained. 3. Of the butyric acid carbon 60% was in equilibrium with 20% of the acetic acid carbon, and 2-3g.atoms of carbon were interconverted/day. 4. Little interconversion took place between propionic acid, acetic acid or butyric acid. 5. The net production rates for acetic acid, propionic acid and butyric acid were 3 7, 1-0 and 0-7moles/day respectively. 6. The production of volatile fatty acids accounted for 80% of the animal's energy expenditure.

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“…Levels of reducing sugars in peripheral blood of adult ruminants are generally lower than in non-ruminant herbivores, such as the horse and rabbit. Concentrations of VFA, on the other hand, are generally higher in ruminants, and provide a major source of energy for the animal (Barcroft, McAnally and Phillipson, 1944). Typical values for these species are presented in Table 3, and show that the concentrations of reducing sugars measured in red kangaroos in the current study are intermediate between those of ruminant and non-ruminant 1941 1944 1950a 1950b 1951 1954 1956 1957 1959 1961 * Values for plasma rather than whole blood.…”

Section: Resultsmentioning

confidence: 99%

BLOOD CHEMISTRY AND GASTRO‐INTESTINAL CHANGES IN THE DEVELOPING RED KANGAROO (MEGALEIA RUFA, DESMAREST)

Barker

1972

Aust J Exp Biol Med

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Summary. The concentration of reducing sugars in peripheral blood of adult, female red kangaroos bas been measured and was found to be intermediate between those of ruminant and non-ruminant herbivores; tbe levels of steam volatile fatty acids resembled those of non-ruminants. The concentration of reducing sugars in pouch-young red kangaroos was similar to that of adults, while volatile fatty acids levels in fully suckling pouch-young were significantly lower than in animals which were both suckling and eating solid food, or in adults; this may bave been related to gastric function. Changes in tlie morphology and histology of the blood erythrocytes, and in the dimensions of the stomach and pH of tbe stomach contents in pouch-young, occurred at an early age (< 100 days), while the animals were still fully suckling. INTRODUCTION.Analogies between tbe anatomy of tbe digestive tract of niacropod marsupials and ruminants were recognised in the nineteenth century (Home, 1814; Owen, 1835), but only recently has this comparison been extended to digestion and metabolism. Moir, Somers, Sharman and Waring (1954) and Moir, Somers and Waring (1956) gave evidence for similarities in tbe digestion and metabolism of carbohydrates in ruminants and a small niacropod marsupial, the quokka (Setonix brachyurus, Quoy and Caimard). This was modified by Barker (1960Barker ( , 1961 who suggested tbat in the quokka these features were intermediate between those of ruminant and non-ruminant herbivores.In the work reported here, blood concentrations of reducing sugars and steam volatile fatty aeids (VFA) have been measured in adults and pouch-young of a large niacropod marsupial, the red kangaroo (Megaleia rufa, Desmarest), for comparison with published values in other herbivorous mammals. Castro-intestinal and haematological changes in tbe developing poucb-young have also been examined.

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Physiological Action of Acetic Acid in Living Tissues

Cited by 21 publications

References 1 publication

Absorption of Volatile Fatty Acids, Tritiated Water and Antipyrine From the Abomasum of Goats

Absorption of Volatile Fatty Acids, Tritiated Water and Antipyrine From the Abomasum of Goats

Interconversions and production of volatile fatty acids in the sheep rumen

BLOOD CHEMISTRY AND GASTRO‐INTESTINAL CHANGES IN THE DEVELOPING RED KANGAROO (MEGALEIA RUFA, DESMAREST)

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