Physiological and Anti-obesity Effects of Melatonin and Niacin Supplements in Rat Models

Keski̇n, Adem; Acı, Recai; Duran, Utku; Sugeçti, Serkan

doi:10.48138/cjo.934158

Cited by 3 publications

(1 citation statement)

References 31 publications

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“…Fukuwatari et al 69 reported that Nicotinic acid has no significant effect on bod weight and food intake in weaning rats. Previous studies also showed that Niacin supplementation decreased body weight in young rats 70 and enhances levels of NAD and expenditure of energy 71 . In regulation of energy metabolism and lipid metabolism NAD+/NADH plays a vital role 72 .…”

Section: Discussionmentioning

confidence: 83%

Protective effects of niacin following high fat rich diet: an in-vivo and in-silico study

Samad,

Manzoor,

Batool

et al. 2023

Sci Rep

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Niacin had long been understood as an antioxidant. There were reports that high fat diet (HFD) may cause psychological and physical impairments. The present study was aimed to experience the effect of Niacin on % growth rate, cumulative food intake, motor activity and anxiety profile, redox status, 5-HT metabolism and brain histopathology in rats. Rats were administered with Niacin at a dose of 50 mg/ml/kg body weight for 4 weeks following normal diet (ND) and HFD. Behavioral tests were performed after 4 weeks. Animals were sacrificed to collect brain samples. Biochemical, neurochemical and histopathological studies were performed. HFD increased food intake and body weight. The exploratory activity was reduced and anxiety like behavior was observed in HFD treated animals. Activity of antioxidant enzymes was decreased while oxidative stress marker and serotonin metabolism in the brain of rat were increased in HFD treated animals than ND fed rats. Morphology of the brain was also altered by HFD administration. Conversely, Niacin treated animals decreased food intake and % growth rate, increased exploratory activity, produced anxiolytic effects, decreased oxidative stress and increased antioxidant enzyme and 5-HT levels following HFD. Morphology of brain is also normalized by the treatment of Niacin following HFD. In-silico studies showed that Niacin has a potential binding affinity with degradative enzyme of 5-HT i.e. monoamine oxidase (MAO) A and B with an energy of ~ − 4.5 and − 5.0 kcal/mol respectively. In conclusion, the present study showed that Niacin enhanced motor activity, produced anxiolytic effect, and reduced oxidative stress, appetite, growth rate, increased antioxidant enzymes and normalized serotonin system and brain morphology following HFD intake. In-silico studies suggested that increase 5-HT was associated with the binding of MAO with Niacin subsequentially an inhibition of the degradation of monoamine. It is suggested that Niacin has a great antioxidant potential and could be a good therapy for the treatment of HFD induced obesity.

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Section: Discussionmentioning

confidence: 83%

Protective effects of niacin following high fat rich diet: an in-vivo and in-silico study

Samad,

Manzoor,

Batool

et al. 2023

Sci Rep

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Organ toxicities associated with diet‐induced obesity in rats: Investigation of changes in activities selected enzymes

Bati

2024

Biotech and App Biochem

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Obesity stands out as one of the most significant health problems in the modern world. The prevalence of high‐calorie diets (HCDs) globally exacerbates this condition. Throughout history, plants and plant‐derived food products have been utilized for medicinal purposes, demonstrating their efficacy in the treatment and prevention of various diseases. Gundelia tournefortii (GT), a plant of interest, is known to possess beneficial properties. Hence, this study aimed to investigate the immunotoxic and neurotoxic effects of two different doses of GT plant extract on the liver, brain, and heart tissues of obese rats. For this purpose, Wistar male rats were divided into four groups: “CG,” “HCDG,” “HCDGUN1,” and “HCDGUN2” At the conclusion of the study, adenosine deaminase (ADA) and myeloperoxidase (MPO) activities, as well as acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) biomarkers, were evaluated in the liver, heart, and brain tissues. The study results revealed a statistically significant increase in ADA and MPO activities in the HCDG group compared to the CG group, alongside a significant decrease in the HCDGUN groups compared to the HCDG group. Regarding AChE and BChE activities, a statistically significant decrease was observed in the HCDG group compared to the CG group, whereas an increase was noted in the HCDGUN groups relative to the HCDG group, with the latter approaching values similar to those of the control group. In conclusion, the intake of GT plant extract exhibited positive effects on the immunotoxic and neurotoxic effects induced by HCD in rats with an experimental obesity model, as evidenced by tissue biomarker evaluations.

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Antioxidant Capacity of Melatonin against Oxidative Stress Caused by Exercise-Induced Weight Loss in Rats

Aci,

Keskin

2023

IJMLST

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Antioxidant supplements such as melatonin are used to prevent oxidative stress during exercise. This study aimed to investigate the antioxidant capacity of melatonin supplementation against oxidative stress induced by the weight loss observed during exercise. Forty Wistar Albino male rats were subjected to 10 days of jogging exercises. Two groups were formed based on weight loss. Two subgroups were created in each group. Melatonin (5 mg/kg) was administered to each subgroup in each group. The other subgroups were designated as control subgroups. Blood samples were collected after 10 d. Superoxide dismutase (SOD), total antioxidant status (TAS), glutathione peroxidase, melatonin, and malondialdehyde levels were analyzed in blood samples. SOD, glutathione peroxidase, TAS, and melatonin levels in the melatonin subgroup were higher than those in the control subgroup in the non-weight loss group. In contrast, the malondialdehyde levels were lower. Melatonin levels in the melatonin subgroup were higher than those in the control subgroup in the weight loss group. Conversely, the SOD and TAS levels were lower. In addition, there was a positive correlation between weight loss and malondialdehyde levels and a negative correlation with SOD, TAS, and melatonin levels. Melatonin (5 mg/kg) supplementation showed antioxidant capacity in exercise without weight loss, but was insufficient in exercise with weight loss.

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Physiological and Anti-obesity Effects of Melatonin and Niacin Supplements in Rat Models

Cited by 3 publications

References 31 publications

Protective effects of niacin following high fat rich diet: an in-vivo and in-silico study

Protective effects of niacin following high fat rich diet: an in-vivo and in-silico study

Organ toxicities associated with diet‐induced obesity in rats: Investigation of changes in activities selected enzymes

Antioxidant Capacity of Melatonin against Oxidative Stress Caused by Exercise-Induced Weight Loss in Rats

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