Physiological and Biochemical Effects of Intrinsically High and Low Exercise Capacities Through Multiomics Approaches

Tung, Yu Tang; Hsu, Yi Ju; Liao, Chen Chung; Ho, Shang Tse; Huang, Chih‐Wei; Huang, Wen Ching

doi:10.3389/fphys.2019.01201

Cited by 22 publications

(25 citation statements)

References 54 publications

(65 reference statements)

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“…Studies showed the potential role of Butyricicoccus in exercise physiology. For example, Tung et al found a greater abundance and diversity of GM in intrinsic high exercise capacity mice than in low exercise capacity mice, indicating the potential effect of GM and functional proteins on intrinsic exercise capacity [41]. The important role of nutrients in muscle strength and HGS has been revealed in previous study [42], which is consistent with our results.…”

Section: Discussionsupporting

confidence: 93%

Associations between gut microbiota and hand grip strength: a polygenetic scoring analysis and genome-wide environmental interaction study

Liu¹,

Cheng²,

Wen³

et al. 2020

Preprint

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Background We aim to explore the genetic association between hand grip strength (HGS) and gut microbiota (GM). Methods The genome-wide association study (GWAS) data of GM was obtained from a recently published study, involving 2,646 individuals. Phenotypic data of left HGS (n = 375,229) and right HGS (n = 375,279) were derived from the UK Biobank. Firstly, PLINK 2.0 was used to calculate 114 GM related polygenetic risk score (PRS) of each subject based on GWAS result. Regression analysis was then conducted to evaluate the possible association of GM-PRS and HGS. Then genome-wide by environment interaction study (GWEIS) of GM related traits was then performed using a regression model adjusted for age, gender, BMI and 10 principal components. Results For PRS analysis, 13 candidate GM were identified to be associated with left HGS (P < 0.05), including G_Bifidobacterium (P = 8.36 × 10− 4), G_Clostridium_sensu_stricto (P = 2.69 × 10− 3), and 10 significant GM for right HGS, such as G_Acidaminococcus (P = 1.29 × 10− 2), G_Streptococcus (P = 1.79 × 10− 2). In addition, 4 GM were found to be overlapped in association with both left and right HGS, including G_Bifidobacterium (P right HGS = 2.78 × 10− 2, P left HGS = 8.36 × 10− 4). Furthermore, several genome-wide significant GWEIS associations were detected for HGS, including 3 significant SNPs interacted with G_Butyricicoccus (P < 5 × 10− 8) for right HGS (rs41310432, P = 3.86 × 10− 8; closest gene: NASP; rs1053941, P = 4.71 × 10− 8; closest gene: NASP; rs6671239, P = 4.73 × 10− 8, closest gene: GPBP1L1), and 1 suggestive intronic SNP in CACNA1H on chromosome 16 interacted with G_Butyricicoccus (rs139206507, P = 8.68 × 10− 8 ) for left HGS. Conclusions Our study holds great potential gaining a better understanding of the relationship between GM and HGS.

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Section: Discussionsupporting

confidence: 93%

Associations between gut microbiota and hand grip strength: a polygenetic scoring analysis and genome-wide environmental interaction study

Liu¹,

Cheng²,

Wen³

et al. 2020

Preprint

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“…These data corroborate previous results obtained by other authors comparing obese children with sedentary and active lifestyles 57 . Moreover, several studies have demonstrated a possible role for gut microbiota in the maintenance of muscle strength, as well as in the adaptation of physiological functions and exercise capacity 58 , 59 . These findings could justify the possible connection between our changes in gut microbiota composition and functionality and the beneficial effects of exercise.…”

Section: Discussionmentioning

confidence: 99%

Exercise training modulates the gut microbiota profile and impairs inflammatory signaling pathways in obese children

Quiroga

Nistal

Estébanez³

et al. 2020

Exp Mol Med

147

120

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Childhood obesity has reached epidemic levels and is a serious health concern associated with metabolic syndrome, nonalcoholic fatty liver disease, and gut microbiota alterations. Physical exercise is known to counteract obesity progression and modulate the gut microbiota composition. This study aims to determine the effect of a 12-week strength and endurance combined training program on gut microbiota and inflammation in obese pediatric patients. Thirty-nine obese children were assigned randomly to the control or training group. Anthropometric and biochemical parameters, muscular strength, and inflammatory signaling pathways in mononuclear cells were evaluated. Bacterial composition and functionality were determined by massive sequencing and metabolomic analysis. Exercise reduced plasma glucose levels and increased dynamic strength in the upper and lower extremities compared with the obese control group. Metagenomic analysis revealed a bacterial composition associated with obesity, showing changes at the phylum, class, and genus levels. Exercise counteracted this profile, significantly reducing the Proteobacteria phylum and Gammaproteobacteria class. Moreover, physical activity tended to increase some genera, such as Blautia, Dialister, and Roseburia, leading to a microbiota profile similar to that of healthy children. Metabolomic analysis revealed changes in short-chain fatty acids, branched-chain amino acids, and several sugars in response to exercise, in correlation with a specific microbiota profile. Finally, the training protocol significantly inhibited the activation of the obesity-associated NLRP3 signaling pathway. Our data suggest the existence of an obesity-related deleterious microbiota profile that is positively modified by physical activity intervention. Exercise training could be considered an efficient nonpharmacological therapy, reducing inflammatory signaling pathways induced by obesity in children via microbiota modulation.

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“…Then, operational taxonomic units (OTUs) with similarity greater than 97% were clustered and a species classification analysis performed. The sequences were further analyzed using a Ribosomal Database Project Naive Bayesian rRNA Classifier (version 2.5) to categorize the microbiota and investigate the relative proportions of microbiota existing in an indicated sample [ 19 ].…”

Section: Methodsmentioning

confidence: 99%

Lactobacillus plantarum PS128 Improves Physiological Adaptation and Performance in Triathletes through Gut Microbiota Modulation

et al. 2020

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A triathlon is an extremely high-intensity exercise and a challenge for physiological adaptation. A triathlete’s microbiome might be modulated by diet, age, medical treatments, lifestyle, and exercise, thereby maintaining aerobiosis and optimum health and performance. Probiotics, prebiotics, and synbiotics have been reported to have health-promoting activities (e.g., immunoregulation and cancer prevention). However, few studies have addressed how probiotics affect the microbiota of athletes and how this translates into functional activities. In our previous study, we found that Lactobacillus plantarum PS128 could ameliorate inflammation and oxidative stress, with improved exercise performance. Thus, here we investigate how the microbiota of triathletes are altered by L. plantarum PS128 supplementation, not only for exercise performance but also for possible physiological adaptation. The triathletes were assigned to two groups: an L. plantarum 128 supplement group (LG, 3 × 1010 colony-forming units (CFU)/day) and a placebo group (PG). Both groups continued with their regular exercise training for the next 4 weeks. The endurance performance, body composition, biochemistries, blood cells, microbiota, and associated metabolites were further investigated. PS128 significantly increased the athletes’ endurance, by about 130% as compared to the PG group, but there was no significant difference in maximal oxygen consumption (VO2max) and composition between groups. The PS128 supplementation (LG) modulated the athlete’s microbiota with both significant decreases (Anaerotruncus, Caproiciproducens, Coprobacillus, Desulfovibrio, Dielma, Family_XIII, Holdemania, and Oxalobacter) and increases (Akkermansia, Bifidobacterium, Butyricimonas, and Lactobacillus), and the LG showed lower diversity when compared to the PG. Also, the short-chain fatty acids (SCFAs; acetate, propionate, and butyrate) of the LG were significantly higher than the PG, which might be a result of a modulation of the associated microbiota. In conclusion, PS128 supplementation was associated with an improvement on endurance running performance through microbiota modulation and related metabolites, but not in maximal oxygen uptake.

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Physiological and Biochemical Effects of Intrinsically High and Low Exercise Capacities Through Multiomics Approaches

Cited by 22 publications

References 54 publications

Associations between gut microbiota and hand grip strength: a polygenetic scoring analysis and genome-wide environmental interaction study

Associations between gut microbiota and hand grip strength: a polygenetic scoring analysis and genome-wide environmental interaction study

Exercise training modulates the gut microbiota profile and impairs inflammatory signaling pathways in obese children

Lactobacillus plantarum PS128 Improves Physiological Adaptation and Performance in Triathletes through Gut Microbiota Modulation

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