Physiological and catecholamine response to sympathetic stimulation in turner syndrome

Zuckerman‐Levin, Nehama; Zinder, Oren; Greenberg, Avital; Levin, Moshe; Jacob, Giris; Hochberg, Zèev

doi:10.1111/j.1365-2265.2006.02483.x

Cited by 43 publications

(36 citation statements)

References 32 publications

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“…These may be related to sympathetic dysregulation. TS patients are associated with increased resting norepinephrine levels and a compromised response to sympathetic stimulation: they have a sympathetic tolerance for physical stress and an inertia for sympathetic stimulation (86).…”

Section: European Journal Of Endocrinologymentioning

confidence: 99%

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TRANSITION IN ENDOCRINOLOGY: Treatment of Turner's syndrome during transition

Gawlik

Małecka-Tendera

2014

European Journal of Endocrinology

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Transition in health care for young patients with Turner's syndrome (TS) should be perceived as a staged but uninterrupted process starting in adolescence and moving into adulthood. As a condition associated with high risk of short stature, cardiovascular diseases, ovarian failure, hearing loss and hypothyroidism, TS requires the attention of a multidisciplinary team. In this review paper, we systematically searched the relevant literature from the last decade to discuss the array of problems faced by TS patients and to outline their optimal management during the time of transfer to adult service. The literature search identified 233 potentially relevant articles of which 114 were analysed. The analysis confirmed that all medical problems present during childhood should also be followed in adult life. Additionally, screening for hypertension, diabetes mellitus, dyslipidaemia, and osteoporosis is needed. After discharge from the paediatric clinic, there is still a long way to go.

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Section: European Journal Of Endocrinologymentioning

confidence: 99%

“…Nevertheless, given the possible b hypersensitivity and increased sympathetic tone found in TS patients, these drugs should be initiated with caution and in smaller than usual dosage. Treatment targeting the overactive SNS may be useful to prevent later cardiovascular complications in these patients (86).…”

Section: Cardiovascular Abnormalities In Transitionmentioning

confidence: 99%

TRANSITION IN ENDOCRINOLOGY: Treatment of Turner's syndrome during transition

Gawlik

Małecka-Tendera

2014

European Journal of Endocrinology

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“…This observation, together with the frequent elevations in systemic BP has led to the hypothesis of altered autonomic nervous system (ANS) activity in this disorder. One study documented a relatively higher heart rate and systolic BP in young women with TS compared to age-matched controls, and a higher level of resting norepinephrine in TS [37]. This study also found a compromised response to sympathetic stimulation in the TS group, and concluded that there is a deregulation of the sympathetic nervous system in TS [37].…”

Section: Abnormalities Of Cardiac Rate Conduction and Repolarizationmentioning

confidence: 84%

“…One study documented a relatively higher heart rate and systolic BP in young women with TS compared to age-matched controls, and a higher level of resting norepinephrine in TS [37]. This study also found a compromised response to sympathetic stimulation in the TS group, and concluded that there is a deregulation of the sympathetic nervous system in TS [37]. Another small study investigated heart rate variability in young adults with TS and reported relatively diminished low frequency power and concluded that there is decreased sympathovagal balance in TS [38].…”

Section: Abnormalities Of Cardiac Rate Conduction and Repolarizationmentioning

confidence: 96%

Spectrum of cardiovascular abnormalities in Turner syndrome

Bondy

Loscalzo

Rosing

2006

International Congress Series

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“…The contribution of both RAA axis and SNS in the pathogenesis of hypertension remains uncertain. SNS is rather over-activated in TS women [16]. Hormone therapy in TS patients is not only a treatment for short stature (growth hormone) and the compensation for sex hormone deficit (sex hormones), but also the counteraction to the deficit www.ah.viamedica.pl effects, including the reduction in the risk of cardiovascular diseases.…”

Section: Introductionmentioning

confidence: 99%

Korzystny wpływ estradiolu na ciśnienie tętnicze, nie na stężenia glukozy i lipidów kobiet z zespołem Turnera

Irzyniec

Jeż

2016

Arterial Hypertension

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Introduction. Turner syndrome (TS) is the form of gonadal malfunction. Arterial hypertension, elevated LDL and glucose and decreased HDL levels are characteristic of TS-women. Hormone therapy is a treatment for short stature and sex hormone deficits. Hormonal replacement therapy (HRT) reduces the risk of cardiovascular diseases. A large percentage of TS-women do not comply with doctors' orders regarding HRT. The analysis of 17b estradiol(E 2 ) levels and the assessment of blood pressure, lipid and carbohydrate metabolisms in TS-women it is possible to state whether HRT decreases the risk of cardiovascular diseases? Material and methods. The group of 95 TS-women, who declared HRT, were investigated. The information about HRT was collected during the anamnesis. E 2 , total cholesterol (TC), high (HDL) and low (LDL) density lipoproteins, triglycerides (TG) and glucose were assessed. Patients were divided into subgroups with E 2 ≥ 110 pmol/L (n = 34) (HE) and < 110 pmol/L (n = 61) (LE) respectively. Results. Arterial hypertension was diagnosed in 26.3%. The groups did not differ in systolic 119 ± 20 versus 118 ± 14 and diastolic 82 ± 13 versus 80 ± 10 mm Hg blood pressure. Despite the higher concentrations of E 2 in HE, no differences were found in weights, lipids and glucose concentrations. Negative correlations between E 2 and body mass (r = -0.25, p = 0.04) and diastolic blood pressure (r = -0.28, p = 0.02) as well as positive between E 2 and glucose (r = 0.24, p < 0.05) were observed only in HE. No correlations between E 2 and lipids were found. Conclusions. 1. Only 1/3 TS-women, who declare HRT, have a satisfactory level of E 2 . 2. In TS-women HRT does not affect glucose and lipid metabolisms. 3. Negative correlation between E 2 and diastolic blood pressure in TS-women suggest beneficial effect of estrogens in hypertension.

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Physiological and catecholamine response to sympathetic stimulation in turner syndrome

Abstract: Turner syndrome is associated with dysregulation of the sympathetic nervous system (SNS), leading to tachycardia and high BP, increased resting norepinephrine levels, and a greater tolerance of the cathecholamine response to exercise.

Cited by 43 publications

References 32 publications

TRANSITION IN ENDOCRINOLOGY: Treatment of Turner's syndrome during transition

TRANSITION IN ENDOCRINOLOGY: Treatment of Turner's syndrome during transition

Spectrum of cardiovascular abnormalities in Turner syndrome

Korzystny wpływ estradiolu na ciśnienie tętnicze, nie na stężenia glukozy i lipidów kobiet z zespołem Turnera

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