Physiological and Clinical Aspects of Bioactive Peptides from Marine Animals

Abstract

Biological molecules in nutraceuticals and functional foods have proven physiological properties to treat human chronic diseases. These molecules contribute to applications in the food and pharmaceutical industries by preventing food spoilage and cellular injury. Technological advancement in the screening and characterization of bioactive peptides has enabled scientists to understand the associated molecules. Consistent collaboration among nutritionists, pharmacists, food scientists, and bioengineers to find new bioactive compounds with higher therapeutic potential against nutrition-related diseases highlights the potential of the bioactive peptides for food and pharmaceutic industries. Among the popular dietary supplements, marine animals have always been considered imperative due to their rich nutritional values and byproduct use in the food and pharmaceutical industries. The bioactive peptides isolated from marine animals are well-known for their higher bioactivities against human diseases. The physiological properties of fish-based hydrolyzed proteins and peptides have been claimed through in vitro, in vivo, and clinical trials. However, systematic study on the physiological and clinical significance of these bioactive peptides is scarce. In this review, we not only discuss the physiological and clinical significance of antioxidant and anticancer peptides derived from marine animals, but we also compare their biological activities through existing in vitro and in vivo studies.

Alaska pollock (Gadus chalcogrammus) proteins and hydrolysed polypeptides: a systematic review of their potential bioactivities

“…In general, peptides from Alaska pollock exhibited antioxidant activity and are influenced by several factors, similar to their potential as ACE inhibitory. The key factors that determine a peptide as a strong antioxidant agent are the amino acid residue structure (C‐ and N‐terminal) and the presence of hydrophobic amino acids (Chakniramol et al ., 2022). Studies by Kim et al .…”

“…In general, peptides from Alaska pollock exhibited antioxidant activity and are influenced by several factors, similar to their potential as ACE inhibitory. The key factors that determine a peptide as a strong antioxidant agent are the amino acid residue structure Gly-Leu-Pro, Leu-Gly-Pro, Leu-Pro-Gly, Pro-Gly-Leu, Pro-Leu-Gly, Gly-Pro, and Pro-Leu (C-and N-terminal) and the presence of hydrophobic amino acids (Chakniramol et al, 2022). Studies by Kim et al (2001), Heu et al (2009), andJe et al (2004) isolated peptides from the skin, frame, and surimi refiner discharge of Alaska pollock and tested their antioxidant activity.…”

Anticancer activities of natural antimicrobial peptides from animals

“…The ocean, accounting for approximately 71% of the earth’s surface area, represents more than half of the biodiversity worldwide. Marine animals are important providers of natural active peptides ( Chakniramol et al, 2022 ). At present, many bioactive peptides with anticancer potential have been identified from various marine animals ( Figure 1 ), mainly concentrated in sponges, mollusks, marine arthropods, ascidians and fish ( Zhang et al, 2021 ; Chakniramol et al, 2022 ; Wong et al, 2023 ).…”

“…Marine animals are important providers of natural active peptides ( Chakniramol et al, 2022 ). At present, many bioactive peptides with anticancer potential have been identified from various marine animals ( Figure 1 ), mainly concentrated in sponges, mollusks, marine arthropods, ascidians and fish ( Zhang et al, 2021 ; Chakniramol et al, 2022 ; Wong et al, 2023 ). Some known ACPs from terrestrial animals ( Figure 1 ), including terrestrial arthropods, amphibians, reptiles and mammals, have also been proven to have broad application prospects, serving as novel anti-tumor drugs or auxiliary therapeutic measures for cancer treatment ( Pan et al, 2020 ; Tornesello et al, 2020 ).…”

Low-Molecular-Mass Fragments of Collagen Improve Parameters Related to Mass and Inflammation of the Adipose Tissue in the Obese Rat

“…The most interesting category of peptides that attracted a lot of attention are collagen bioactive peptides derived from animal by-products ( 12 ), including those derived from organisms that live in extreme conditions ( 13 ). They include molecules derived from cold-adaptive hydrobionts.…”