Physiological and pharmacological perspectives of melatonin

Samanta, Saptadip

doi:10.1080/13813455.2020.1770799

Cited by 45 publications

(27 citation statements)

References 281 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Other studies have reported that melatonin impairs glucose tolerance in humans, especially in G-allele carriers [53]. However, currently, controversy still exists regarding the potential mechanisms involved, as well as on the beneficial or unfavorable effects of the endogenous and/or exogenous melatonin in humans [50][51][52][53][54][55][56][57][58]. Some of these controversial results may be partially explained by taking into account the existence of heterogeneous effects of the MTNR1B polymorphism by age.…”

Section: Discussionmentioning

confidence: 99%

“…An age-related chronobiological hypothesis was suggested by Hardeland [69] to explain the contradictory results on the favorable or unfavorable effects of the melatonin on glucose metabolism in humans. According to this researcher, whether melatonin may be harmful in type-2 diabetes of humans, despite its antidiabetic results in rodents [51][52][53][54][55]58], remains to be elucidated and may partly depend on age. The reductions in melatonin secretion associated with aging as well the deteriorating circadian system and the proinflammatory changes may play a major role [70].…”

Section: Discussionmentioning

confidence: 99%

“…Circadian rhythms and sleep quality are closely regulated by melatonin, a crucial hormone determining the sleep-wake cycle in humans [18]. However, currently, there is considerable controversy over the favorable or unfavorable effects of melatonin on glucose metabolism and the risk of diabetes [50][51][52][53][54][55][56][57][58], considering that the results of studies both on humans and animals have often been inconsistent. In a recent review [58], these discrepancies were analyzed in-depth and one of the factors contributing to those discrepancies was the characteristics of the population studied, including chronological age [58].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Chronological Age Interacts with the Circadian Melatonin Receptor 1B Gene Variation, Determining Fasting Glucose Concentrations in Mediterranean Populations. Additional Analyses on Type-2 Diabetes Risk

et al. 2020

View full text Add to dashboard Cite

Gene-age interactions have not been systematically investigated on metabolic phenotypes and this modulation will be key for a better understanding of the temporal regulation in nutrigenomics. Taking into account that aging is typically associated with both impairment of the circadian system and a decrease in melatonin secretion, we focused on the melatonin receptor 1B (MTNR1B)-rs10830963 C>G variant that has been associated with fasting glucose concentrations, gestational diabetes, and type-2 diabetes. Therefore, our main aim was to investigate whether the association between the MTNR1B-rs10830963 polymorphism and fasting glucose is age dependent. Our secondary aims were to analyze the polymorphism association with type-2 diabetes and explore the gene-pregnancies interactions on the later type-2 diabetes risk. Three Mediterranean cohorts (n = 2823) were analyzed. First, a cross-sectional study in the discovery cohort consisting of 1378 participants (aged 18 to 80 years; mean age 41 years) from the general population was carried out. To validate and extend the results, two replication cohorts consisting of elderly individuals were studied. In the discovery cohort, we observed a strong gene-age interaction (p = 0.001), determining fasting glucose in such a way that the increasing effect of the risk G-allele was much greater in young (p = 5.9 × 10−10) than in elderly participants (p = 0.805). Consistently, the association of the MTNR1B-rs10830963 polymorphism with fasting glucose concentrations in the two replication cohorts (mean age over 65 years) did not reach statistical significance (p > 0.05 for both). However, in the elderly cohorts, significant associations between the polymorphism and type-2 diabetes at baseline were found. Moreover, in one of the cohorts, we obtained a statistically significant interaction between the MTNR1B polymorphism and the number of pregnancies, retrospectively assessed, on the type-2 diabetes risk. In conclusion, the association of the MTNR1B-rs10830963 polymorphism with fasting glucose is age-dependent, having a greater effect in younger people. However, in elderly subjects, associations of the polymorphism with type-2 diabetes were observed and our exploratory analysis suggested a modulatory effect of the number of past pregnancies on the future type-2 diabetes genetic risk.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Chronological Age Interacts with the Circadian Melatonin Receptor 1B Gene Variation, Determining Fasting Glucose Concentrations in Mediterranean Populations. Additional Analyses on Type-2 Diabetes Risk

et al. 2020

View full text Add to dashboard Cite

show abstract

“…MLT acts as a chronobiotic agent as well as a sleep-promoting factor, immune regulator, and jet lag problem reducing agent [6]. Besides these, it has anti-carcinogenic functions by modulating the estradiol synthesis, cell cycle regulation, induction of apoptosis [7,8] as well as anti-angiogenic effects, antioxidant properties, and immune cell regulation through several cytokines production [3,8]. MLT is considered a potent natural antitumor hormone; an elevated level of this hormone decreases the risk of development of a variety of cancer in different tissues, including the ovary.…”

Section: Introductionmentioning

confidence: 99%

The promising oncostatic effects of melatonin against ovarian cancer

Das

Samanta

2021

World Journal of Current Med and Pharm Research

Self Cite

View full text Add to dashboard Cite

Melatonin is a pineal hormone, secreted at the subjective night. It is involved in the regulation of many physiological functions, including the sleep-wake cycle, gonadal activity, free radical scavenging, immunomodulation, neuro-protection, and cancer progression. Melatonin acts through cell surface receptors (MT1 and MT2) as well as nuclear receptors. Circadian dysfunction can alter the secretion of melatonin. Inappropriate melatonin level promotes the initiation of many pathologies including cancer. Ovarian cancer is a common form of gynecological disease. Several studies indicate the profound link between impaired melatonin secretion and the progression of ovarian cancer. Melatonin exerts oncostatic effects in multiple ways; it acts as a potent antioxidant, induces apoptosis, and regulates metabolism, and chronic inflammatory response in ovarian cancer cells. Moreover, melatonin improves the efficacy of the current treatment regimen of ovarian cancer and can be used as an adjuvant.

show abstract

“…Subarachnoid hemorrhage (SAH) is a serious disease that develops spontaneously or due to trauma, and it is thought that melatonin may have positive effects on SAH (1)(2)(3). Melatonin secretion in the pineal gland is regulated by light stimulation, and superior cervical ganglion has an important place in this regulation (4)(5)(6). Whether traumatic or spontaneous SAH can be defined as extravasation of blood into subarachnoid space of brain (7,8).…”

Section: Introductionmentioning

confidence: 99%

Sıçan Subaraknoid Kanama Modelinde Bilateral Superior Servikal Ganglionektomi ve Melatonin Seviyeleri: Basit Önlemler Melatonin Düzeylerini Koruyabilir

KILIÇ

KAYABAŞ

CANCAN

2021

Düzce Tıp Fakültesi Dergisi

View full text Add to dashboard Cite

Aim: Subarachnoid hemorrhage (SAH) is a serious disease, and it is thought that melatonin may have positive effects after SAH. Bilateral resection or blockage of superior cervical ganglions has constant effects on melatonin levels. Animal models with bilateral superior cervical ganglionectomy (SCG) show the role of superior cervical ganglion on melatonin and give clues about simple precautions which may help to prevent unfavorable outcomes in SAH patients. The aim of this study is to examine how melatonin levels change in SAH and SCG models. Material and Methods: Forty-two Sprague Dawley male rats weighing 200-250 g were used in the study and randomly divided into six groups. Arterial blood samples were collected 24 hours after the procedure in all groups. Serum melatonin levels of the groups were studied. Results: A significant difference in blood melatonin levels was observed between SAH and SCG groups, and against the control group. There was no significant difference between the melatonin levels in SCG group and SAH+SCG group (p=0.983). The mean blood melatonin level of the SAH group was higher than the SCG (p<0.001), SAH+SCG (p<0.001) and control groups (p=0.001). The mean blood melatonin levels of SAH+SCG and SCG groups were lower than the mean blood melatonin levels of the other groups and also the SAH group (p<0.001). Conclusion: Bilateral SCG significantly inhibited the abrupt increase of serum melatonin levels after SAH model in rats. Future studies aiming to address melatonin's complex outcomes should take into account that minor exogenous factors may affect serum melatonin levels.

show abstract

Physiological and pharmacological perspectives of melatonin

Cited by 45 publications

References 281 publications

Chronological Age Interacts with the Circadian Melatonin Receptor 1B Gene Variation, Determining Fasting Glucose Concentrations in Mediterranean Populations. Additional Analyses on Type-2 Diabetes Risk

Chronological Age Interacts with the Circadian Melatonin Receptor 1B Gene Variation, Determining Fasting Glucose Concentrations in Mediterranean Populations. Additional Analyses on Type-2 Diabetes Risk

The promising oncostatic effects of melatonin against ovarian cancer

Sıçan Subaraknoid Kanama Modelinde Bilateral Superior Servikal Ganglionektomi ve Melatonin Seviyeleri: Basit Önlemler Melatonin Düzeylerini Koruyabilir

Contact Info

Product

Resources

About