Physiological and transcriptomic effects of hexafluoropropylene oxide dimer acid in Caenorhabditis elegans during development

Feng, Zuying; McLamb, Flannery; Vu, Jeanne P.; Gong, Sylvia; Gersberg, Richard M.; Bozinovic, Goran

doi:10.1016/j.ecoenv.2022.114047

Cited by 13 publications

(13 citation statements)

References 105 publications

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“…Students engaged in active learning by applying research skills to ongoing authentic research projects during the LSRIP. Among the four research themes, the AS project has resulted in a manuscript published in the journal Ecology and Evolution featuring two program participants as coauthors while two more were acknowledged for specific project contributions ( 41 ), a CT manuscript has been published in the journal Ecotoxicology and Environmental Safety ( 42 ), and two DM manuscripts are in preparation. Per consistent verbal feedback from most students during the program, collaborative student-instructor interactions minimized traditional student-teacher hierarchy and promoted active conversations instead of lecturing, establishing greater comfort among students.…”

Section: Discussionmentioning

confidence: 99%

Life Science Research Immersion Program Improves STEM-Specific Skills and Science Attitudes among Precollege Students

Dong

Feng

McLamb

et al. 2023

J Microbiol Biol Educ.

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A predicted rapid growth in science, technology, engineering, and math (STEM) careers demands a vast and talented workforce, but students most commonly abandon STEM majors within the first 2 years of college. Performance in introductory courses, scientific literacy, and the ability to critically reason are main predictors of retention in STEM, highlighting the importance of precollege and early college experience.

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Section: Discussionmentioning

confidence: 99%

Life Science Research Immersion Program Improves STEM-Specific Skills and Science Attitudes among Precollege Students

Dong

Feng

McLamb

et al. 2023

J Microbiol Biol Educ.

Self Cite

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“…We conducted an extensive literature search across databases to identify transcriptomics studies focusing on the effects of PFAS on animal samples. A total of 11 transcriptomics datasets were identified, containing publicly available data from 7 different species (Homo sapiens, Mus musculus, Caenorhabditis elegans, Danio rerio, Gadus morhua, Micropterus salmoides, Pimephales promelas) (Table 1) [38][39][40][41][43][44][45][46][47][48][49]. Data associated with these studies were retrieved from the Gene Expression Omnibus (GEO) database (https://www.ncbi.nlm.nih.gov/geo/) [50] and the Sequence Read Archive (SRA) database (https://www.ncbi.nlm.nih.gov/sra) [51], both hosted at the National Center for Biotechnology Information (NCBI).…”

Section: Data Collection and Processingmentioning

confidence: 99%

Cross-species Transcriptomics Analysis Highlights Conserved Molecular Responses to Per- and Polyfluoroalkyl Substances (PFAS)

Beccacece¹,

Costa²,

Pascali³

et al. 2023

Preprint

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In the recent decades, per- and polyfluoroalkyl substances (PFAS) have garnered widespread public attention due to their persistence in the environment and detrimental effects on the health of living organisms, spurring the generation of several transcriptome-centered investigations to understand the biological basis of their mechanism. In this study, we analyzed 2144 publicly available datasets from 7 distinct species to examine the molecular responses to PFAS exposure and determine if there are conserved responses. Our comparative transcriptional analysis revealed that exposure to PFAS is conserved across different tissues, molecules and species. We identified and reported several genes exhibiting consistent and evolutionarily conserved transcriptional re-sponse to PFAS, such as ESR1, HADHA and ID1, as well as several pathways including lipid me-tabolism, immune response and hormone pathways. This study provides the first evidence that distinct PFAS molecules induce comparable transcriptional changes and affect the same metabolic processes across inter-species borders. Our findings have significant implications for under-standing the impact of PFAS exposure on living organisms and the environment. We believe that this study offers a novel perspective on the molecular responses to PFAS exposure and provides a foundation for future research into developing strategies for mitigating the detrimental effects of these substances.

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“…We conducted an extensive literature search across databases to identify all transcriptome-wide quantitative studies focusing on the effects of PFAS on animal samples. A total of 11 transcriptomics datasets were identified, containing publicly available data from 7 different species (Homo sapiens, Mus musculus, Caenorhabditis elegans, Danio rerio, Gadus morhua, Micropterus salmoides, Pimephales promelas) (Table 1) [38][39][40][41][43][44][45][46][47][48][49]. Raw data associated with these studies were retrieved from the Gene Expression Omnibus (GEO) database (https://www.ncbi.nlm.nih.gov/geo/) [50] and the Sequence Read Archive (SRA) database (https://www.ncbi.nlm.nih.gov/sra) [51], both hosted at the National Center for Biotechnology Information (NCBI).…”

Section: Data Collection and Processingmentioning

confidence: 99%

“…Numerous studies have demonstrated that PFAS affect multiple species through detectable molecular mechanisms [38][39][40][41]. These compounds can directly interact with molecules such as the peroxisome proliferator-activated receptor α (PPARα), which mediates PFAS toxicity [42].…”

Section: Introductionmentioning

confidence: 99%

Cross-species Transcriptomics Analysis Highlights Conserved Molecular Responses to Per- and Polyfluoroalkyl Substances (PFAS)

Beccacece¹,

Costa²,

Pascali³

et al. 2023

Preprint

View full text Add to dashboard Cite

In the recent decades, per- and polyfluoroalkyl substances (PFAS) have garnered widespread public attention due to their persistence in the environment and detrimental effects on the health of living organisms, spurring the generation of several transcriptome-centered investigations to understand the biological basis of their mechanism. In this study, we collected 2144 publicly available samples from 7 distinct animal species to examine the molecular responses to PFAS exposure and to determine if there are conserved responses. Our comparative transcriptional analysis revealed that exposure to PFAS is conserved across different tissues, molecules and species. We identified and reported several genes exhibiting consistent and evolutionarily conserved transcriptional response to PFAS, such as ESR1, HADHA and ID1, as well as several pathways including lipid metabolism, immune response and hormone pathways. This study provides the first evidence that distinct PFAS molecules induce comparable transcriptional changes and affect the same metabolic processes across inter-species borders. Our findings have significant implications for understanding the impact of PFAS exposure on living organisms and the environment. We believe that this study offers a novel perspective on the molecular responses to PFAS exposure and provides a foundation for future research into developing strategies for mitigating the detrimental effects of these substances in the ecosystem.

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Physiological and transcriptomic effects of hexafluoropropylene oxide dimer acid in Caenorhabditis elegans during development

Cited by 13 publications

References 105 publications

Life Science Research Immersion Program Improves STEM-Specific Skills and Science Attitudes among Precollege Students

Life Science Research Immersion Program Improves STEM-Specific Skills and Science Attitudes among Precollege Students

Cross-species Transcriptomics Analysis Highlights Conserved Molecular Responses to Per- and Polyfluoroalkyl Substances (PFAS)

Cross-species Transcriptomics Analysis Highlights Conserved Molecular Responses to Per- and Polyfluoroalkyl Substances (PFAS)

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