Physiological basis of the pathogenesis of alcohol-induced skeletal muscle injury

Zinovyeva, O. E.; Emelyanova, A. Yu.; Самхаева, Н. Д.; Shcheglova, N. S.; Шенкман, Борис; Nemirovskaya, T. L.

doi:10.1134/s0362119716020171

Cited by 3 publications

(4 citation statements)

References 46 publications

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“…Although it is known that chronic ethanol consumption can adversely affect skeletal muscle and lead to alcoholic myopathy [ 19 , 21 ], the actual deficit in physiological characteristics and contractile properties of whole muscles due to ethanol consumption/administration has only very recently been studied in animal models.…”

Section: Discussionmentioning

confidence: 99%

“…Alcoholic myopathy, characterized by skeletal muscle weakness and atrophy, affects many consumers with a history of chronic alcohol abuse [ 18 , 19 , 20 ]. Clinical studies and preclinical laboratory research have led to an understanding of some of the mechanisms involved in alcoholic myopathy associated with chronic consumption, such as alteration in anabolic and catabolic pathways, impaired regeneration, increased inflammation and fibrotic markers, and deficiencies in mitochondrial function leading to energy imbalance and increased oxidative stress [ 14 , 19 , 21 , 22 ]. Nevertheless, whether similar, or other pathological mechanisms occur as a result of episodic BD has been less explored.…”

Section: Introductionmentioning

confidence: 99%

“…Nevertheless, whether similar, or other pathological mechanisms occur as a result of episodic BD has been less explored. For example, most studies in animal models use chronic or acute (single dose) ethanol exposure, whereas investigations in humans concentrate on the history of chronic consumers or perform protocols of acute ethanol administration, usually below BD doses [ 14 , 18 , 19 , 21 , 23 ]. Therefore, episodic BD, the most common consumption pattern in youth and sportspeople, is under-represented in all these studies.…”

Section: Introductionmentioning

confidence: 99%

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Episodic Binge-like Ethanol Reduces Skeletal Muscle Strength Associated with Atrophy, Fibrosis, and Inflammation in Young Rats

Cáceres-Ayala

Mira

Acuña

et al. 2023

IJMS

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Binge Drinking (BD) corresponds to episodes of ingestion of large amounts of ethanol in a short time, typically ≤2 h. BD occurs across all populations, but young and sports-related people are especially vulnerable. However, the short- and long-term effects of episodic BD on skeletal muscle function have been poorly explored. Young rats were randomized into two groups: control and episodic Binge-Like ethanol protocol (BEP) (ethanol 3 g/kg IP, 4 episodes of 2-days ON-2-days OFF paradigm). Muscle function was evaluated two weeks after the last BEP episode. We found that rats exposed to BEP presented decreased muscle strength and increased fatigability, compared with control animals. Furthermore, we observed that skeletal muscle from rats exposed to BEP presented muscle atrophy, evidenced by reduced fiber size and increased expression of atrophic genes. We also observed that BEP induced fibrotic and inflammation markers, accompanied by mislocalization of nNOSµ and high levels of protein nitration. Our findings suggest that episodic binge-like ethanol exposure alters contractile capacity and increases fatigue by mechanisms involving atrophy, fibrosis, and inflammation, which remain for at least two weeks after ethanol clearance. These pathological features are common to several neuromuscular diseases and might affect muscle performance and health in the long term.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Episodic Binge-like Ethanol Reduces Skeletal Muscle Strength Associated with Atrophy, Fibrosis, and Inflammation in Young Rats

Cáceres-Ayala

Mira

Acuña

et al. 2023

IJMS

View full text Add to dashboard Cite

show abstract

“…One typical alteration related to ethanol intake is chronic alcoholic myopathy that occurs in 40-60 percent of chronic alcoholics (Fernandez-Sola et al, 2007;Simon et al, 2017;Urbano-Marquez and Fernandez-Sola, 2004) which leads to muscular atrophy of type II fibers. Type II muscle fibers are more affected than type I fibers (Adachi et al, 2003;Duran Castellon et al, 2005;Gonzalez-Reimers et al, 2010;Nemirovskaya et al, 2015;Otis et al, 2007;Otis and Guidot, 2009;Preedy and Peters, 1990;Reilly et al, 2000;Zinovyeva et al, 2016), and this atrophy develops independently of alcohol-induced disorders (Zinovyeva et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Cholecalciferol in ethanol-preferring rats muscle fibers increases the number and area of type II fibers

et al. 2018

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The chronic use of ethanol causes neuropathy and atrophy of type II fibers and promotes vitamin D decrease. This study evaluated cholecalciferol effects on the deep fibular nerve and extensor digitorum longus (EDL) muscle using an UChB ethanol-preferring rats model. Blood analyses were carried out to measure levels of 25-hydroxycholecalciferol (25(OH)D), calcium (Ca), Phosphorus (P), and parathyroid hormone (PTH). It was used EDL muscle to evaluate oxidative stress. The deep fibular nerve and EDL muscle were used for morphologic and morphometric assessment. 25(OH)D plasma levels were higher in the supplemented group and no alterations were observed in other parameters including the oxidative stress evaluation. The G ratio remained constant which indicates nervous conduction normality. Cholecalciferol supplementation promoted an increase in the number and area of type II fibers and a decrease in the area of type I fibers. In the studied model, there was neither alcoholic myopathy nor neuropathy. The EDL muscle glycolytic patterns in the high-drinker UChB rats may be associated with the differential effects of cholecalciferol on metabolism and protein synthesis in skeletal muscle.

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The response of skeletal muscle to alcohol abuse: Gender differences

et al. 2016

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Physiological basis of the pathogenesis of alcohol-induced skeletal muscle injury

Cited by 3 publications

References 46 publications

Episodic Binge-like Ethanol Reduces Skeletal Muscle Strength Associated with Atrophy, Fibrosis, and Inflammation in Young Rats

Episodic Binge-like Ethanol Reduces Skeletal Muscle Strength Associated with Atrophy, Fibrosis, and Inflammation in Young Rats

Cholecalciferol in ethanol-preferring rats muscle fibers increases the number and area of type II fibers

The response of skeletal muscle to alcohol abuse: Gender differences

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