Physiological changes associated with copper sulfate-induced nausea and retching in felines

Murphey, Charles P.; Shulgach, Jonathan A.; Amin, Pooja R.; Douglas, Nerone K.; Bielanin, John P.; Sampson, Jacob T.; Horn, Charles C.; Yates, Bill J

doi:10.3389/fphys.2023.1077207

Cited by 5 publications

(2 citation statements)

References 47 publications

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“…Orally consumed poisonous CuSO 4 can trigger a particular vagal-induced vomiting reaction and can injure the mucous membranes in the GIT since CuSO 4 is effective as an oxidizing and corrosive agent 51 , 52 . The GIT’s visceral afferent nerve fibers are stimulated by peripheral processes, which subsequently transmit the stimulation toward the VC, causing the act of vomiting 53 , 54 .…”

Section: Discussionmentioning

confidence: 99%

Antiemetic activity of abietic acid possibly through the 5HT3 and muscarinic receptors interaction pathways

Hasan,

Alshammari,

Albekairi

et al. 2024

Sci Rep

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The present study was designed to evaluate the antiemetic activity of abietic acid (AA) using in vivo and in silico studies. To assess the effect, doses of 50 mg/kg b.w. copper sulfate (CuSO4⋅5H2O) were given orally to 2-day-old chicks. The test compound (AA) was given orally at two doses of 20 and 40 mg/kg b.w. On the other hand, aprepitant (16 mg/kg), domperidone (6 mg/kg), diphenhydramine (10 mg/kg), hyoscine (21 mg/kg), and ondansetron (5 mg/kg) were administered orally as positive controls (PCs). The vehicle was used as a control group. Combination therapies with the referral drugs were also given to three separate groups of animals to see the synergistic and antagonizing activity of the test compound. Molecular docking and visualization of ligand-receptor interaction were performed using different computational tools against various emesis-inducing receptors (D2, D3, 5HT3, H1, and M1–M5). Furthermore, the pharmacokinetics and toxicity properties of the selected ligands were predicted by using the SwissADME and Protox-II online servers. Findings indicated that AA dose-dependently enhances the latency of emetic retching and reduces the number of retching compared to the vehicle group. Among the different treatments, animals treated with AA (40 mg/kg) exhibited the highest latency (98 ± 2.44 s) and reduced the number of retching (11.66 ± 2.52 times) compared to the control groups. Additionally, the molecular docking study indicated that AA exhibits the highest binding affinity (− 10.2 kcal/mol) toward the M4 receptors and an elevated binding affinity toward the receptors 5HT3 (− 8.1 kcal/mol), M1 (− 7.7 kcal/mol), M2 (− 8.7 kcal/mol), and H1 (− 8.5 kcal/mol) than the referral ligands. Taken together, our study suggests that AA has potent antiemetic effects by interacting with the 5TH3 and muscarinic receptor interaction pathways. However, additional extensive pre-clinical and clinical studies are required to evaluate the efficacy and toxicity of AA.

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Section: Discussionmentioning

confidence: 99%

Antiemetic activity of abietic acid possibly through the 5HT3 and muscarinic receptors interaction pathways

Hasan,

Alshammari,

Albekairi

et al. 2024

Sci Rep

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“…The exact anti-diarrhoea and antiemetic mechanism of FT leaf extract is not clear. However, since it is able to inhibit copper sulphate-induced retching, which is elicited via peripheral mechanism, it is believed that FT leaf extract has peripheral anti-emetic action [25]. On the other hand, with respect to its anti-diarrhoea mechanism, FT leaf extract can be deduced to block the diarrhoeal responses elicited by the metabolites of castor oil, ricinoleic acid and perhaps nitric oxide.…”

Section: Discussionmentioning

confidence: 99%

Antidiarrhoeal and anti-emetic activities of aqueous leaf extract of <i>Ficus thonningii</i> Blume in young chicks

Tijjani,

Abubakar,

Aminu

et al. 2024

CaJoST

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Treatments for diarrhoeal and vomiting with modern drugs have been associated with unwanted effects such as sedation and extrapyramidal effects. In this study, Ficus thonningii Blume leaf extract (FTE) was investigated for its anti-diarrhoeal and anti-emetic properties. Two study groups, namely anti-diarrhoeal and anti-emetic groups (n=36), were sorted into: placebo; drug-treatment, and 3 plant-extract treatment (FT100, FT200 and FT300) subgroups (n = 6). In the placebo group, chicks were administered only saline solution (0.9 %) while chlorpromazine (150 mg/kg) and loperamide (2.5 mg/kg) served as positive control in the anti-emetic and antidiarrhoeal study groups, respectively. The plant-extract treatment groups (FT100, FT200 and FT300) were treated with 100, 200, and 300 mg/kg doses of FTE, respectively. Vomiting was induced using oral copper sulphate solution (50 mg/kg) and chicks were observed for latency as-well-as number of retches. In the anti-diarrhoea study group, 30 mins after treatment with extracts, diarrhoea was induced with oral castor oil and latency as-well-as number of defecation was observed. Results revealed that treatment with 200 and 300 mg/kg of FTE, similar to chlorpromazine, inhibited the number of retching in chicks by 71% and 78%, respectively. Treatment with 100, 200 and 300 mg/kg of FTE, similar to loperamide, reduced the number of droppings in chicks by 45.4%, 42.9%, and 58.4%, respectively. Thus, the results showed that FTE possess anti-emetic and anti-diarrhoeal properties which qualifies it a potential research candidate in search of new drugs.

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Synergistic Antiemetic Effects of Nerolidol on Domperidone, Hyoscine, and Ondansetron: In Vivo and in Silico Investigations on Receptor Binding Affinity

Ghosh Situ,

Bhuia,

Chowdhury

et al. 2024

ChemistryOpen

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The present study was designed to measure the potential antiemetic properties of nerolidol (NDL) via in vivo and in silico studies. To induce emesis copper sulfate pentahydrate (CuSO4.5H2O) was administered at a dose of 50 mg/kg (orally) to 2‐day‐old chicks. The test sample (NDL) was given at two doses of 50 and 100 mg/kg. b.w. orally. Additionally, aprepitant (16 mg/kg), domperidone (6 mg/kg), hyoscine (21 mg/kg), ondansetron (5 mg/kg), and diphenhydramine (10 mg/kg) were given also orally as positive controls. To observe the modulatory effects of the test sample, combination therapies with reference drugs were also administered to three different groups of animals. Molecular docking and visualization of ligand‐receptor interaction were performed against several emesis‐inducing receptors (5HT3, D2, D3, H1, and M1‐M5) using diverse computational tools. Pharmacokinetics and drug‐likeness of the selected ligands were also calculated. Findings demonstrated that NDL significantly (p <0.05) dose‐dependently lessens the mean number of retches and delays the emetic onset in the chicks. The combined drug therapy with ondansetron exposed better antiemetic activity. In addition, in silico analysis, NDL has greater binding affinity (−7.3 kcal/mol) against M2 and M3 receptors. In conclusion, NDL exerted mild antiemetic activity with synergistic properties through muscarinic receptors.

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Physiological changes associated with copper sulfate-induced nausea and retching in felines

Cited by 5 publications

References 47 publications

Antiemetic activity of abietic acid possibly through the 5HT3 and muscarinic receptors interaction pathways

Antiemetic activity of abietic acid possibly through the 5HT3 and muscarinic receptors interaction pathways

Antidiarrhoeal and anti-emetic activities of aqueous leaf extract of <i>Ficus thonningii</i> Blume in young chicks

Synergistic Antiemetic Effects of Nerolidol on Domperidone, Hyoscine, and Ondansetron: In Vivo and in Silico Investigations on Receptor Binding Affinity

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