Physiological contribution of P2X receptors in postreceptoral signal processing in the mouse retina

Ichinohe, Sho; Ishii, Takeaki; Takahashi, Hiroshi; Kaneda, Makoto

doi:10.1016/j.neures.2016.09.012

Cited by 1 publication

(1 citation statement)

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“…In the CNS, P2XRs participate in modulation of neurotransmission, neuron-glia communication, inflammation, and apoptosis. [136][137][138][139] Adenosine 5 0 -triphosphate released under physiological conditions modulate synaptic plasticity by acting on P2X receptors via Ca 2þdependent interaction with the NMDA receptors that facilitate LTP in the hippocampus. 140 In general, overexpression of the P2X 3 , P2X 4 , and P2X 7 receptors have been detected in CNS disorders and their antagonists could potentially be useful therapies for the treatment of CNS diseases including neurodegeneration and brain injuries.…”

Section: P2x Receptors and Functions In The Cnsmentioning

confidence: 99%

Purinergic Receptors of the Central Nervous System: Biology, PET Ligands, and Their Applications

Zarrinmayeh

Territo

2020

Mol Imaging

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Purinergic receptors play important roles in central nervous system (CNS). These receptors are involved in cellular neuroinflammatory responses that regulate functions of neurons, microglial and astrocytes. Based on their endogenous ligands, purinergic receptors are classified into P1 or adenosine, P2X and P2Y receptors. During brain injury or under pathological conditions, rapid diffusion of extracellular adenosine triphosphate (ATP) or uridine triphosphate (UTP) from the damaged cells, promote microglial activation that result in the changes in expression of several of these receptors in the brain. Imaging of the purinergic receptors with selective Positron Emission Tomography (PET) radioligands has advanced our understanding of the functional roles of some of these receptors in healthy and diseased brains. In this review, we have accumulated a list of currently available PET radioligands of the purinergic receptors that are used to elucidate the receptor functions and participations in CNS disorders. We have also reviewed receptors lacking radiotracer, laying the foundation for future discoveries of novel PET radioligands to reveal these receptors roles in CNS disorders.

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