Physiological Correlates of Positive Symptoms in Schizophrenia

Galderisi, Silvana; Vignapiano, A.; Mucci, Armida; Boutros, Nash N.

doi:10.1007/7854_2014_322

Cited by 14 publications

(13 citation statements)

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“…The results of the correlation analysis in the present study revealed that the PSE of delay detection was correlated with the PSE of agency attenuation, indicating that sensorimotor integration ability was closely related to the explicit SoA. A previous study also reported that patients with schizophrenia exhibiting an abnormal explicit SoA simultaneously exhibited impaired sensorimotor integration [29], suggesting a close relationship between sensorimotor integration ability and explicit SoA from a clinical perspective. To the best of our knowledge, the current study is the first to successfully reveal the relationship between sensorimotor integration and SoA with an experimental paradigm involving the delay detection task and the agency attribution task.…”

Section: Discussionsupporting

confidence: 66%

The relationship and difference between delay detection ability and judgment of sense of agency

et al. 2019

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Judgment of agency involves the comparison of motor intention and proprioceptive/visual feedback, in addition to a range of cognitive factors. However, few studies have experimentally examined the differences or correlations between delay detection ability and judgment of agency. Thus, the present study investigated the relationship between delay detection ability and agency judgment using the delay detection task and the agency attribution task. Fifty-eight participants performed the delay detection and agency attribution tasks, and the time windows of each measure were analyzed using logistic curve fitting. The results revealed that the time window of judgment of agency was significantly longer than that of delay detection, and there was a slight correlation between the time windows in each task. The results supported a two-step model of agency, suggesting that judgment of agency involved not only comparison of multisensory information but also several cognitive factors. The study firstly revealed the model in psychophysical experiments.

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Section: Discussionsupporting

confidence: 66%

The relationship and difference between delay detection ability and judgment of sense of agency

et al. 2019

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“…While no between-group differences were observed for intensity MMN amplitude, in EP participants we observed that increased positive symptoms are associated with increased intensity MMN peak latency. This offers some small support to the theory that the aberrant intrinsic organization of functional brain networks associated with positive symptoms can be indexed with electrophysiological measures 68 and suggests that this may extend to the early phase of the illness. While this is, to our knowledge, the first report of an association between MMN latency and clinical symptoms in early phase schizophrenia, similar findings of increased positive symptoms being observed with concurrent decreases in MMN amplitude have been seen in chronic schizophrenia, albeit with duration 69 and novel 53 deviants.…”

Section: Mmn Amplitudes and Latenciesmentioning

confidence: 60%

Auditory Mismatch Negativity and P300a Elicited by the “Optimal” Multi-feature Paradigm in Early Schizophrenia

et al. 2018

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The mismatch negativity (MMN) is an EEG-derived event-related potential (ERP) elicited by any violation of a predicted auditory "rule," regardless of whether one is attending to the stimuli and is thought to reflect updating of the stimulus context. Redirection of attention toward a rare, distracting stimulus event, however, can be measured by the subsequent P3a component of the P300. Chronic schizophrenia patients exhibit robust MMN deficits, as well as reductions in P3a amplitude. While, the substantial literature on the MMN in first-episode and early phase schizophrenia in this population reports reduced amplitudes, there also exist several contradictory studies. Conversely, P3a reduction in this population is relatively consistent, although the literature investigating this is small. The primary goal of this study was to contribute to our understanding of whether auditory change detection mechanisms are altered in early phase schizophrenia and, if so, under what conditions. Event-related potentials elicited by duration, frequency, gap, intensity, and location deviants (as elicited by the "optimal" multi-feature paradigm) were recorded in 14 early phase schizophrenia (EP) patients and 17 healthy controls (HCs). Electrical activity was recorded from 15 scalp electrodes. MMN/P3a amplitudes and latencies for each deviant were compared between groups and were correlated with clinical measures in EPs. There were no significant group differences for MMN amplitudes or latencies, though EPs did exhibit reduced P3a amplitudes to gap and duration deviants. Furthermore, PANSS (Positive and Negative Syndrome Scale) positive symptom scores were correlated with intensity MMN latencies and duration P3a amplitudes in EPs. These findings suggest that MMNs may not be as robustly reduced in early phase schizophrenia (relative to chronic illness), but that alterations may be more likely in patients with increased positive symptomatology. Furthermore, these findings offer further support to previous work suggesting that the understudied P3a may have good complementary utility as a marker of early cortical dysfunction in psychosis.

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“…A vast EEG literature has documented different abnormalities of neuronal activity in subjects with chronic SCZ, as compared to healthy controls (HCs) ( 29 , 33 , 43 – 49 ). In particular, several studies have consistently reported alterations in the activity of the whole spectrum of frequency bands ( 49 – 53 ), changes in MSs topography and/or other parameters ( 46 , 47 , 54 ) and a reduction of amplitude in ERPs, such as N100 ( 55 – 58 ), mismatch negativity (MMN) ( 59 , 60 ), and P300 ( 33 , 57 , 61 ). Furthermore, these alterations have been related to the severity of symptoms, as well as cognitive and functional impairment in schizophrenia.…”

Section: Introductionmentioning

confidence: 99%

EEG-Based Measures in At-Risk Mental State and Early Stages of Schizophrenia: A Systematic Review

et al. 2021

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Introduction: Electrophysiological (EEG) abnormalities in subjects with schizophrenia have been largely reported. In the last decades, research has shifted to the identification of electrophysiological alterations in the prodromal and early phases of the disorder, focusing on the prediction of clinical and functional outcome. The identification of neuronal aberrations in subjects with a first episode of psychosis (FEP) and in those at ultra high-risk (UHR) or clinical high-risk (CHR) to develop a psychosis is crucial to implement adequate interventions, reduce the rate of transition to psychosis, as well as the risk of irreversible functioning impairment. The aim of the review is to provide an up-to-date synthesis of the electrophysiological findings in the at-risk mental state and early stages of schizophrenia.Methods: A systematic review of English articles using Pubmed, Scopus, and PsychINFO was undertaken in July 2020. Additional studies were identified by hand-search. Electrophysiological studies that included at least one group of FEP or subjects at risk to develop psychosis, compared to healthy controls (HCs), were considered. The heterogeneity of the studies prevented a quantitative synthesis.Results: Out of 319 records screened, 133 studies were included in a final qualitative synthesis. Included studies were mainly carried out using frequency analysis, microstates and event-related potentials. The most common findings included an increase in delta and gamma power, an impairment in sensory gating assessed through P50 and N100 and a reduction of Mismatch Negativity and P300 amplitude in at-risk mental state and early stages of schizophrenia. Progressive changes in some of these electrophysiological measures were associated with transition to psychosis and disease course. Heterogeneous data have been reported for indices evaluating synchrony, connectivity, and evoked-responses in different frequency bands.Conclusions: Multiple EEG-indices were altered during at-risk mental state and early stages of schizophrenia, supporting the hypothesis that cerebral network dysfunctions appear already before the onset of the disorder. Some of these alterations demonstrated association with transition to psychosis or poor functional outcome. However, heterogeneity in subjects' inclusion criteria, clinical measures and electrophysiological methods prevents drawing solid conclusions. Large prospective studies are needed to consolidate findings concerning electrophysiological markers of clinical and functional outcome.

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Physiological Correlates of Positive Symptoms in Schizophrenia

Cited by 14 publications

References 100 publications

The relationship and difference between delay detection ability and judgment of sense of agency

The relationship and difference between delay detection ability and judgment of sense of agency

Auditory Mismatch Negativity and P300a Elicited by the “Optimal” Multi-feature Paradigm in Early Schizophrenia

EEG-Based Measures in At-Risk Mental State and Early Stages of Schizophrenia: A Systematic Review

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