Physiological determinants of the variation in left ventricular mass from early adolescence to late adulthood in healthy subjects

Abstract

Normal LVM shows variation over a broad age range in both genders with a rise in adolescence and subsequent decline with increasing age in adulthood despite an increase in SBP and physical activity. BSA, age, and gender were found to be major contributors to the variation in LVM in healthy adults, while haemodynamic factors, exercise, and wall stress were not.

MRI comparison of quantitative left ventricular structure, function and measurement reproducibility in patient cohorts with a range of clinically distinct cardiac conditions

“…The reason for the elevated LVM CoR in the LVH cohort is somewhat less explainable, although may have been in part due to poor differentiation of hypertrophic myocardial borders and errors associated with identifying the enlarged papillary muscles and trabeculae often associated with the endocardial border. Recent studies have also identified a dependency of LVM variation with age [14] and gender [15]. Neither variable was specifically controlled for in this study and as such might influence the magnitude of the mean values obtained for each clinical cohort, but neither parameter were expected to influence the repeatability parameters significantly.…”

Gender-Related Differences in Adolescent Hypertension and in Target Organ Effects

“…An interesting finding of the present study is related to target organ damage in adolescent female and male hypertensives. Increased LVMI in male hypertensive teenagers compared with females has to be evaluated with caution, as previous studies have also suggested that LVMI is increased in males without hypertension as well, 22 and the difference in LVMI between hypertensive boys and girls might also be related to gender differences in hypertension. 7 This finding was not supported by our study, however, as we found no differences in LVMI of normotensive girls and boys.…”

Periodontitis links to exacerbation of myocardial dysfunction in subjects with type 2 diabetes

“…Another critical point is that despite a comparable DM duration, subjects with periodontitis tend to be older than the Controls. LV mass has been found to be elevated in adolescence and subsequently decreased with aging in adulthood . It is therefore possible that there may be a sequential change in LV wall thickness from hypertrophy to wasting along with aging.…”