Physiological Effects of Concentrated Barley β-Glucan in Mildly Hypercholesterolemic Adults

Smith, Kristen N; Queenan, Katie M; Thomas, William; Fulcher, R. G.; Slavin, Joanne L.

doi:10.1080/07315724.2008.10719722

Cited by 66 publications

(34 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Mnohé studie prokazují (Keogh et al, 2003;Chen a Raymond, 2008;Shimizu et al, 2008;Smith et al, 2008;Babio et al, 2010;Mitsou et al, 2010;Samuelsen et al, 2011;El Khoury et al, 2012;Tovar et al, 2012), že beta-glukany (podobně jako arabinoxylany) v lidské stravě pomáhají snižovat hladinu LDL cholesterolu a hladinu glukosy v krvi, inzulinovou odezvu po jídle, tělesnou hmotnost, krevní tlak, riziko srdeční choroby i rakoviny tlustého střeva a zároveň zmírňují průběh diabetu II. typu.…”

Section: Sladovnicky a Dieteticky Významné Neškrobové Polysacharidy Zunclassified

“…There are many studies (Keogh et al, 2003;Chen and Raymond, 2008;Shimizu et al, 2008;Smith et al, 2008;Babio et al, 2010;Mitsou et al, 2010;Samuelsen et al, 2011;El Khoury et al, 2012;Tovar et al, 2012) proving that beta-glucans (similarly as arabinoxylans) in human diet help lower LDL cholesterol and glucose level in blood, insulin response to meal, body weight, blood pressure, risk of heart diseases and colon cancer and simultaneously they alleviate the course of type II diabetes. As a prebioticum, they stimulate in the colon the growth of bacteria producing volatile fatty acids, which create an unsuitable environment for the growth of pathogenic bacterial species, at the same time they act as nutrients for intestinal enterocytes.…”

Section: Sladovnicky a Dieteticky Významné Neškrobové Polysacharidy Zmentioning

confidence: 99%

See 1 more Smart Citation

Barley grain non-starch polysaccharides with malting and nutritional significance.

Macháň¹,

Ehrenbergerová²,

Cerkal³

2014

Kvasny Prum

View full text Add to dashboard Cite

258Kvasny prum. 60 / 2014 (10) Sladovnicky a dieteticky významné neškrobové polysacharidy zrna ječmeneKlíčová slova: arabinoxylany, beta-glukany, ječmen jarní ■ ■ 1 ÚVOD Ječmen setý (Hordeum vulgare L.) je na našem území tradiční zemědělskou plodinou, jež zde byla pěstována již tisíce let před naším letopočtem (Ullrich, 2010). V současnosti je ječmen setý s obě-ma formami (jarní a ozimou) naší druhou nejpěstovanější obilninou. Historicky byla většina produkce ječmene jarního v České republice využívána ke krmení hospodářských zvířat, v posledních letech však můžeme pozorovat trend kontinuálního snižování spotřeby ječmene pro krmení hospodářských zvířat, což je dáno snižováním stavů hospodářských zvířat (zejména prasat a drůbeže) chovaných v České republice. V roce 2013 převažovala spotřeba ječmene pro potravinářské využití nad množstvím určeným ke zkrmování (Kůst a Potměšilová, 2013). Pro každý způsob využití produkce ječmene je požadováno zrno vyhovující specifickým parametrům. Mezi důležité parametry z tohoto pohledu patří i obsah neškrobových polysacharidů -zejména arabinoxylanů a beta-glukanů. V pivovarském průmy-slu představují neškrobové polysacharidy nežádoucí látky (Kosař et al., 2000). Na druhou stranu ječné neškrobové polysacharidy jsou ve Sladovnicky a dieteticky významné neškrobové polysacharidy zrna ječmene Barley Grain Non-starch Polysaccharides with Malting and Nutritional SignificancePavel MACHÁŇ, Jaroslava EHRENBERGEROVÁ, Radim CERKAL Mendelova univerzita v Brně, Zemědělská 1, 613 00 Brno / Mendel University in Brno, Zemědělská 1, CZ-613 00 Brno e-mail: xmachan1@node.mendelu.czRecenzovaný článek / Reviewed paper Macháň, P. -Ehrenbergerová, J. -Cerkal, R.: Sladovnicky a dieteticky významné neškrobové polysacharidy zrna ječmene. Kvasny Prum. 60, 2014, č. 10, s. 258-265 Neškrobové polysacharidy (NSP) tvořící hlavní část buněčných stěn zrna ječmene (arabinoxylany a beta-glukany) představují limitující faktor pro využití produkce ječmene. Arabinoxylany jsou tvořeny (1→4)-ß-D-xylanopyrosylovými jednotkami substituovanými a-L-arabinofuranózou. Arabinoxylany jsou esterifikovány kyselinou ferulovou. Beta-glukany jsou tvořeny ß-(1→3),(1→4)-D-glukany, přičemž glukosidická ß-(1→4) se vyskytuje přibližně ze 70 %, vazba ß-(1→3) pak ze zbývajících 30 %. Koncentrace NSP v zrnu ječmene je ovlivněna zejména genotypem, pěstebním prostředím a intenzitou ošetření porostů. V procesu vaření piva mohou NSP způsobovat technologické i ekonomické problémy. Jejich obsah je však možno v průběhu výroby piva snížit přídavkem příslušných hydrolytických enzymů. NSP tvoří však také hodnotnou složku potravní vlákniny, jež pomáhá snižovat hladinu LDL cholesterolu a hladinu glukózy v krvi, inzulinovou odezvu po jídle, tělesnou hmotnost, krevní tlak, riziko srdeční choroby i rakoviny tlustého střeva a zároveň zmírňuje průběh diabetu II. typu. Jako prebiotikum tvoří nevhodné prostředí pro růst patogenních rodů bakterií. Na základě vědeckých posudků vydala Evropská Komise nařízení č. 1048/2012, ve kterém schvaluje zdravotní tvrzení ...

show abstract

Section: Sladovnicky a Dieteticky Významné Neškrobové Polysacharidy Zunclassified

Section: Sladovnicky a Dieteticky Významné Neškrobové Polysacharidy Zmentioning

confidence: 99%

Barley grain non-starch polysaccharides with malting and nutritional significance.

Macháň¹,

Ehrenbergerová²,

Cerkal³

2014

Kvasny Prum

View full text Add to dashboard Cite

show abstract

“…Four randomised controlled trials were identified that presented evidence on β-glucan in relation to fasting insulin concentration, all of which were included in a meta-analysis (Saltzman et al, 2001;Chen et al, 2006;Maki et al, 2007a;Smith et al, 2008). Two trials were subsequently identified in the update search (Bays et al, 2011;Charlton et al, 2012) (Cardio-metabolic review, diabetes and glycaemia chapter p 311-312; Update search table 161).…”

Section: Fasting Insulinmentioning

confidence: 99%

“…Oat bran and β-glucans and fasting triacylglycerol concentration  Effect  Moderate evidence  The direction of the effect demonstrates higher consumption higher consumption of oat bran or β-glucan supplementation is beneficial to health  The effect is biologically relevant Fasting blood glucose 8.87. Four randomised controlled trials were identified that presented evidence on oat bran and β-glucan supplements in relation to fasting blood glucose concentration, all of which were included in a meta-analysis (Saltzman et al, 2001;Chen et al, 2006;Maki et al, 2007a;Smith et al, 2008). Two trials were subsequently identified in the update search (Bays et al, 2011;Charlton et al, 2012) (Cardio-metabolic review, diabetes and glycaemia chapter p 308-310; Update search table 155).…”

mentioning

confidence: 99%

Macronutrients and type 1 diabetes (revision number 6)

Garden¹,

Paterson²

2014

Diapedia

View full text Add to dashboard Cite

“…single arm interventions without a control (placebo) group (Dongowski et al, 2006;Ikegami et al, 1996;Smith et al, 2008). One acute trial (Bourdon et al, 1999) measured postprandial plasma lipids after the intake of test meals.…”

Section: Scientific Substantiation Of the Claimed Effectmentioning

confidence: 99%

Scientific Opinion on the substantiation of a health claim related to barley beta-glucans and lowering of blood cholesterol and reduced risk of (coronary) heart disease pursuant to Article 14 of Regulation (EC) No 1924/2006

2011

EFSA Journal

View full text Add to dashboard Cite

Following an application from Valens Int. d.o.o. submitted pursuant to Article 14 of Regulation (EC) via the Competent Authority of Slovenia, the Panel on Dietetic Products, Nutrition and Allergies was asked to deliver an opinion on the scientific substantiation of a health claim related to barley beta-glucans and lowering of blood cholesterol and reduced risk of (coronary) heart disease, referring to disease risk reduction and including a request for the protection of proprietary data. The food constituent that is the subject of the health claim, barley beta-glucans, is sufficiently characterised. Lowering blood LDL-cholesterol concentration is a beneficial physiological effect by decreasing the risk of coronary heart disease. The applicant identified a total of eight references as being pertinent to the health claim. These references included two meta-analyses and six human studies. In weighing the evidence, the Panel took into account that one meta-analysis including 11 RCTs, and one additional RCT, which investigated the effects of barley beta-glucans at doses of at least 3 g/day showed a decrease in total and LDL-cholesterol concentrations in both normo-and hypercholesterolaemic subjects, and that there is evidence supporting the biological plausibility of the mechanism of the effect. The Panel concludes that a cause and effect relationship has been established between the consumption of barley beta-glucans and lowering of blood LDL-cholesterol concentrations. The following wording reflects the scientific evidence: "Barley beta-glucans have been shown to lower/reduce blood cholesterol. High cholesterol is a risk factor in the development of coronary heart disease". At least 3 g of barley beta-glucans should be consumed per day in order to obtain the claimed effect. The target population is adults who want to lower their blood cholesterol concentrations. © European Food Safety Authority, 2011 KEY WORDSBarley beta-glucans, fibre, blood cholesterol, LDL-cholesterol, health claims. Allergies was asked to deliver an opinion on the scientific substantiation of a health claim related to barley beta-glucans and lowering of blood cholesterol and reduced risk of (coronary) heart disease.The scope of the application was proposed to fall under a health claim referring to disease risk reduction and including a request for the protection of proprietary data.The food constituent that is the subject of the health claim is barley beta-glucans. Beta-glucans are non-starch polysaccharides composed of glucose molecules in long linear polymers. Beta-glucans occur naturally in barley and are measurable in foods by established methods. This opinion applies to barley beta-glucans naturally present in foods, and to those forms added to foods. The Panel considers that the food constituent, barley beta-glucans, which is the subject of the health claim, is sufficiently characterised.The claimed effect is "reduction of blood cholesterol, which may reduce the risk of heart disease". The target population proposed by the applica...

show abstract

Physiological Effects of Concentrated Barley β-Glucan in Mildly Hypercholesterolemic Adults

Abstract: Overall, supplementation with isolated barley beta-glucans of different molecular weights had small effects on cardiovascular disease markers. Molecular weight of the barley fiber did alter effects on body weight with the high-MW fiber significantly decreasing body weight.

Cited by 66 publications

References 30 publications

Barley grain non-starch polysaccharides with malting and nutritional significance.

Barley grain non-starch polysaccharides with malting and nutritional significance.

Macronutrients and type 1 diabetes (revision number 6)

Scientific Opinion on the substantiation of a health claim related to barley beta-glucans and lowering of blood cholesterol and reduced risk of (coronary) heart disease pursuant to Article 14 of Regulation (EC) No 1924/2006

Contact Info

Product

Resources

About