Physiological Evidence Concerning Importance of the Amygdaloid Nuclear Region in the Integration of Circulatory Function and Emotion in Man

Chapman, William P.; Schroeder, Heinz; Geyer, G; Brazier, Mary A. B.; Fager, Charles A.; Poppen, James L.; Solomon, Harry C.; Yakovlev, Paul I.

doi:10.1126/science.120.3127.949

Cited by 154 publications

(59 citation statements)

References 4 publications

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“…In humans, electrical stimulation of the amygdala elicits feelings of fear or anxiety as well as autonomic reactions indicative of fear. 31,32 While other emotional reactions occasionally are produced, the major reaction is one of fear or apprehension. However, it is not clear whether these effects result from activation of the CeA or more widespread effects to other parts of the extended amygdala.…”

Section: Autonomic and Hormonal Measuresmentioning

confidence: 99%

The amygdala: vigilance and emotion

2000

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Here we provide a review of the animal and human literature concerning the role of the amygdala in fear conditioning, considering its potential influence over autonomic and hormonal changes, motor behavior and attentional processes. A stimulus that predicts an aversive outcome will change neural transmission in the amygdala to produce the somatic, autonomic and endocrine signs of fear, as well as increased attention to that stimulus. It is now clear that the amygdala is also involved in learning about positively valenced stimuli as well as spatial and motor learning and this review strives to integrate this additional information. A review of available studies examining the human amygdala covers both lesion and electrical stimulation studies as well as the most recent functional neuroimaging studies. Where appropriate, we attempt to integrate basic information on normal amygdala function with our current understanding of psychiatric disorders, including pathological anxiety. Molecular Psychiatry (2001) 6, 13-34.

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Section: Autonomic and Hormonal Measuresmentioning

confidence: 99%

The amygdala: vigilance and emotion

2000

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“…In humans, electrical stimUlation of the central amygdala elicits feelings of fear or anxiety, as well as similar autonomic reactions indicative of fear (Chapman et al, 1954;Gloor et l'Il., 1981).…”

Section: The Loyal Vement Of the Central Amygdala In Anxietymentioning

confidence: 99%

The effect of kindling of different nuclei in the left and right amygdala on anxiety in the rat

Adamec

Morgan

1994

Physiology & Behavior

119

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“…These fear response patterns are similar in animals and humans (110). Electrical stimulation of the amygdala elicits fear and anxiety responses in both humans (34,70) and animals (94), and lesions of the amygdala block the expression of certain, but not all, types of unconditioned fear. For example, rats with amygdala lesions show reduced freezing in response to cats (17) or cat hair (276), attenuated analgesia and heart rate responses to a loud noise (14,298), and have reduced taste neophobia (182).…”

Section: Role Of the Amygdaloid Complexmentioning

confidence: 99%

The Amygdaloid Complex: Anatomy and Physiology

Sah

Faber

Armentia

et al. 2003

Physiological Reviews

1,469

1,336

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Sah, P., E. S. L. Faber, M. Lopez de Armentia, and J. Power. The Amygdaloid Complex: Anatomy and Physiology. Physiol Rev 83: 803–834, 2003; 10.1152/physrev.00002.2003.—A converging body of literature over the last 50 years has implicated the amygdala in assigning emotional significance or value to sensory information. In particular, the amygdala has been shown to be an essential component of the circuitry underlying fear-related responses. Disorders in the processing of fear-related information are likely to be the underlying cause of some anxiety disorders in humans such as posttraumatic stress. The amygdaloid complex is a group of more than 10 nuclei that are located in the midtemporal lobe. These nuclei can be distinguished both on cytoarchitectonic and connectional grounds. Anatomical tract tracing studies have shown that these nuclei have extensive intranuclear and internuclear connections. The afferent and efferent connections of the amygdala have also been mapped in detail, showing that the amygdaloid complex has extensive connections with cortical and subcortical regions. Analysis of fear conditioning in rats has suggested that long-term synaptic plasticity of inputs to the amygdala underlies the acquisition and perhaps storage of the fear memory. In agreement with this proposal, synaptic plasticity has been demonstrated at synapses in the amygdala in both in vitro and in vivo studies. In this review, we examine the anatomical and physiological substrates proposed to underlie amygdala function.

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Physiological Evidence Concerning Importance of the Amygdaloid Nuclear Region in the Integration of Circulatory Function and Emotion in Man

Cited by 154 publications

References 4 publications

The amygdala: vigilance and emotion

The amygdala: vigilance and emotion

The effect of kindling of different nuclei in the left and right amygdala on anxiety in the rat

The Amygdaloid Complex: Anatomy and Physiology

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