2010
DOI: 10.1016/j.brainres.2010.08.026
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Physiological evidence for two classes of mitral cells in the rat olfactory bulb

Abstract: The spontaneous activity of mitral cells was recorded in vivo from the main olfactory bulb of freely breathing anesthetized rats. Single units recorded extracellularly from the mitral cell body layer were further identified as mitral cells by antidromic activation of the lateral olfactory tract and the posterior piriform cortex. Hierarchical cluster analysis of their spontaneous activity showed that at least two classes of mitral cells could be distinguished. A post-hoc multivariate analysis of variance indica… Show more

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Cited by 8 publications
(9 citation statements)
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“…That feature was also noted by Nica et al. () in eight of the 29 mitral cells that they reported (recorded in the rat) – however, these authors did not describe long‐duration bursting, possibly because most of their recordings were relatively short in duration (median duration 400 sec).…”
Section: Introductionsupporting
confidence: 69%
See 1 more Smart Citation
“…That feature was also noted by Nica et al. () in eight of the 29 mitral cells that they reported (recorded in the rat) – however, these authors did not describe long‐duration bursting, possibly because most of their recordings were relatively short in duration (median duration 400 sec).…”
Section: Introductionsupporting
confidence: 69%
“…These authors also reported another feature of mitral cell activity for the first timethat the distribution of interspike intervals was often bimodal, with an early mode that reflects the frequent occurrence of spikes separated by very short intervals (<10 msec). That feature was also noted by Nica et al (2010) in eight of the 29 mitral cells that they reported (recorded in the rat)however, these authors did not describe long-duration bursting, possibly because most of their recordings were relatively short in duration (median duration 400 sec).…”
Section: Introductionmentioning
confidence: 61%
“…In anesthetized rodents, MTCs fire spontaneously over a wide ∼1-40 Hz range (mean rates ∼14-18 Hz) with faster instantaneous rates during bursts or odors (Chaput and Holley, 1979;Chaput and Panhuber, 1982;Yu et al, 1993;Jiang et al, 1996;Davison and Katz, 2007;Nica et al, 2010). Spontaneous firing rates in awake rodents are generally similar to that in anesthetized preparations; range, 1-33 Hz, mean range, 12-17 Hz (Kay and Laurent, 1999;Fuentes et al, 2008;Shusterman et al, 2011).…”
Section: Mtc Spontaneous Firing and Intrinsic Membrane Propertiesmentioning
confidence: 88%
“…Already during early development, neurons in sensory and limbic brain areas generate distinct firing patterns and assemble into circuits synchronized in different frequency bands (Khazipov et al, 2004;Brockmann et al, 2011;Minlebaev et al, 2011;Bitzenhofer et al, 2015;Hartung et al, 2016;Ahlbeck et al, 2018). At this age, when most sensory inputs do not reach the cortex, spontaneous and stimulus- While the intrinsic firing properties of MCs have been investigated extensively in adult rodents (Yu et al, 1993;Balu et al, 2004;Nica et al, 2010;Angelo & Margrie, 2011), little is known about their firing properties during early postnatal development.…”
Section: Discussionmentioning
confidence: 99%
“…MCs of the adult OB have been extensively characterized in their passive and active properties (Balu et al, 2004;Padmanabhan & Urban, 2010;Angelo & Margrie, 2011;Kollo et al, 2014). According to the firing patterns, these neurons have been classified as regular firing and irregular bursting (or "stuttering") (Yu et al, 1993;Balu et al, 2004;Nica et al, 2010;Angelo & Margrie, 2011;Burton & Urban, 2014;Leng et al, 2014). The MC firing patterns relate to the hyperpolarization-evoked sag potentials, irregular bursting MCs having less pronounced sag currents when compared to regular firing MCs (Angelo & Margrie, 2011;Burton & Urban, 2014).…”
Section: Introductionmentioning
confidence: 99%