Physiological function and inflamed-brain migration of mouse monocyte-derived macrophages following cellular uptake of superparamagnetic iron oxide nanoparticles—Implication of macrophage-based drug delivery into the central nervous system

Tong, Hsin-I; Wen, Kai; Shi, Yunfan; Zhou, Guang‐Zhou; Lu, Yuanan

doi:10.1016/j.ijpharm.2016.03.028

Cited by 30 publications

(28 citation statements)

References 32 publications

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“…It can be seen that the measurement results seem to be somewhat abnormal and have little correlation with the nominal core sizes. The results of DLS measurements using the same magnetic particles as us are not entirely consistent in other studies [35,36,37]. This may be caused by measurement errors, methods, etc., or more complex underlying causes.…”

Section: Resultssupporting

confidence: 47%

Characterization and Relaxation Properties of a Series of Monodispersed Magnetic Nanoparticles

Zhang

Cheng

Liu

2019

Sensors

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Magnetic iron oxide nanoparticles are relatively advanced nanomaterials, and are widely used in biology, physics and medicine, especially as contrast agents for magnetic resonance imaging. Characterization of the properties of magnetic nanoparticles plays an important role in the application of magnetic particles. As a contrast agent, the relaxation rate directly affects image enhancement. We characterized a series of monodispersed magnetic nanoparticles using different methods and measured their relaxation rates using a 0.47 T low-field Nuclear Magnetic Resonance instrument. Generally speaking, the properties of magnetic nanoparticles are closely related to their particle sizes; however, neither longitudinal relaxation rate r 1 nor transverse relaxation rate r 2 changes monotonously with the particle size d . Therefore, size can affect the magnetism of magnetic nanoparticles, but it is not the only factor. Then, we defined the relaxation rates r i ′ (i = 1 or 2) using the induced magnetization of magnetic nanoparticles, and found that the correlation relationship between r 1 ′ relaxation rate and r 1 relaxation rate is slightly worse, with a correlation coefficient of R 2 = 0.8939, while the correlation relationship between r 2 ′ relaxation rate and r 2 relaxation rate is very obvious, with a correlation coefficient of R 2 = 0.9983. The main reason is that r 2 relaxation rate is related to the magnetic field inhomogeneity, produced by magnetic nanoparticles; however r 1 relaxation rate is mainly a result of the direct interaction of hydrogen nucleus in water molecules and the metal ions in magnetic nanoparticles to shorten the T 1 relaxation time, so it is not directly related to magnetic field inhomogeneity.

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Section: Resultssupporting

confidence: 47%

Characterization and Relaxation Properties of a Series of Monodispersed Magnetic Nanoparticles

Zhang

Cheng

Liu

2019

Sensors

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“…Macrophages transporting superparamagnetic iron oxide nanoparticles and exogenous genes were injected intravenously into a lipopolysaccharide-induced acute neuroinflammatory mouse model. The differentiated macrophages demonstrated an excellent ability to spread into the brain, and the number of transported macrophages positively correlated with the number of intravenous cells (Tong et al, 2016). Moreover, macrophage exosomes can interact with brain microvessel endothelial cells that comprise the BBB by binding to carbohydrate-binding C-type lectin receptors.…”

Section: Therapeutic Perspectivesmentioning

confidence: 99%

Targeting Microglia and Macrophages: A Potential Treatment Strategy for Multiple Sclerosis

et al. 2019

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Multiple sclerosis (MS) is a chronic inflammatory neurodegenerative disease of the central nervous system (CNS). The early stage is characterized by relapses and the later stage, by progressive disability. Results from experimental and clinical investigations have demonstrated that microglia and macrophages play a key part in the disease course. These cells actively initiate immune infiltration and the demyelination cascade during the early phase of the disease; however, they promote remyelination and alleviate disease in later stages. This review aims to provide a comprehensive overview of the existing knowledge regarding the neuromodulatory function of macrophages and microglia in the healthy and injured CNS, and it discusses the feasibility of harnessing microglia and macrophage physiology to treat MS. The review encourages further investigations into macrophage-targeted therapy, as well as macrophage-based drug delivery, for realizing efficient treatment strategies for MS.

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“…loading macrophage membrane surfaces with nanoparticles can be carried out by extrusion or in an ultrasonic bath. Macrophage membrane coatings have been critical in prolonging the circulation time of nano-drug delivery systems in vivo, further enhancing the efficiency of drug delivery and therapeutic efficacy (Tong et al, 2016;Zhang et al, 2018;Xia et al, 2020). Therefore, the macrophage-based nanosystems exhibit great potential for controlled drug delivery in periodontitis treatment.…”

Section: Discussionmentioning

confidence: 99%

Injecting Immunosuppressive M2 Macrophages Alleviates the Symptoms of Periodontitis in Mice

Miao

et al. 2020

Front. Mol. Biosci.

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Periodontitis is the second most common oral disease affecting tooth-supporting structures. The tissue damage is mainly initiated by the excessive secretion of proinflammatory cytokines by immune cells. Macrophages are a type of antigenpresenting cells that influence the adaptive immunity function. We used a unique set of cytokines, i.e., a combination of IL-4, IL-13, and IL-10, to stimulate macrophages into a subset of M2 polarization cells that express much higher levels of ARG-1, CD206, and PDL-2 genes. The cells' anti-inflammatory potential was tested with mixedlymphocyte reaction assay, which showed that this subset of macrophages could increase IL-2 secretion and suppress IL-17, IL-6, and TNF-α secretion by splenocytes. The gram-negative bacterial species Porphyromonas gingivalis was used to initiate an inflammatory process in murine periodontal tissues. In the meantime, cell injection therapy was used to dampen the excessive immune reaction and suppress osteoclast differentiation during periodontitis. Maxilla was collected and analyzed for osteoclast formation. The results indicated that mice in the cell injection group exhibited less osteoclast activity within the periodontal ligament region than in the periodontitis group. Moreover, the injection of M2 macrophages sustained the regulatory population ratio. Therefore, the M2 macrophages induced under the stimulation of IL-4, IL-13, and IL-10 combined had tremendous immune modulation ability. Injecting these cells into local periodontal tissue could effectively alleviate the symptom of periodontitis.

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Physiological function and inflamed-brain migration of mouse monocyte-derived macrophages following cellular uptake of superparamagnetic iron oxide nanoparticles—Implication of macrophage-based drug delivery into the central nervous system

Cited by 30 publications

References 32 publications

Characterization and Relaxation Properties of a Series of Monodispersed Magnetic Nanoparticles

Characterization and Relaxation Properties of a Series of Monodispersed Magnetic Nanoparticles

Targeting Microglia and Macrophages: A Potential Treatment Strategy for Multiple Sclerosis

Injecting Immunosuppressive M2 Macrophages Alleviates the Symptoms of Periodontitis in Mice

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