Physiological gastroesophageal reflux and esophageal motor activity studied with a new system for 24-hour recording and automated analysis

Smout, A. J. P. M.; Breedijk, M.; Zouw, C. van der; Akkermans, L. M. A.

doi:10.1007/bf01536258

Cited by 153 publications

(82 citation statements)

References 14 publications

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“…Normal values for control subjects undergoing conventional catheterbased pH monitoring were used to determine whether oesophageal acid exposure was normal. [7][8][9][10][11][12][13][14] Representative tracings obtained from the Bravo capsule are illustrated in Figures 3 and 4. Six patients also underwent colonoscopy during the same endoscopic session, four (67%) of whom had positive tests.…”

Section: Resultsmentioning

confidence: 99%

Successful oesophageal pH monitoring with a catheter‐free system

Ward

DeVault

Bouras

et al. 2004

Aliment Pharmacol Ther

103

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SUMMARYBackground: Traditional catheter-based oesophageal pH testing is limited by patient discomfort and the tendency for patients to alter their diet and activities during the study. A catheter-free pH monitoring system (Bravo) designed to avoid these problems has recently become available, but the advantages and limitations of this device have not been fully explored. Aim: To report our initial experience with this new technology. Methods: The records of consecutive patients undergoing Bravo pH monitoring were reviewed. The squamo-columnar junction was localized endoscopically and the pH capsule was placed 6 cm above this junction. All patients were re-endoscoped immediately following placement to document mucosal attachment. Patients were monitored for 24-48 h and then returned the radiotelemetry recording device. Data were subsequently downloaded to a personal computer.

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Section: Resultsmentioning

confidence: 99%

Successful oesophageal pH monitoring with a catheter‐free system

Ward

DeVault

Bouras

et al. 2004

Aliment Pharmacol Ther

103

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“…Recently, Smout et al 8 compared 16 young healthy volunteers (mean age 31 years) and a similar number of healthy older volunteers (mean age 61 years, range 45-73 years) without the problem of restricted age ranges in the two previous studies. 9,10 The subjects were composed of 16 males and 16 females.…”

Section: Discussionmentioning

confidence: 99%

Normal 24-hour Ambulatory Esophageal pH Values in Koreans

Moon

Park²,

Kim³

et al. 2008

Gut Liver

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Background/Aims: Twenty-four-hour ambulatory esophageal pH monitoring is considered the gold standard for diagnosing gastroesophageal reflux disease. The aim of this study was to quantify normal distal esophageal acid parameters in healthy Koreans. Methods: Thirty healthy adults who were not on medication and were free from gastrointestinal symptoms were analyzed. Ambulatory esophageal acid (pH ＜4) exposure parameters were recorded at 5 cm above the lower esophageal sphincter. Results: The 95th percentiles for reflux parameters assessed in the distal esophagus were as follows: percentage of total time with pH ＜4, 5.10%; percentage of upright time with pH ＜4, 7.88%; percentage of supine time with pH ＜4, 4.00%; number of reflux episodes, 62.7; number of reflux episodes with pH ＜4 for ＞5 minutes, 5.3; and the longest single acid-exposure episode, 21.3 minutes. Conclusions: Physiological gastroesophageal reflux occurs frequently in healthy Koreans. These data provide a reference range that could be utilized in studies involving Korean subjects. (Gut and Liver 2008;2:8-13)

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“…However, it should be noted that these studies were not accomplished in individuals who would, by today's standards, be regarded as "older adults." A study that used modern technology in a group that would be considered older was performed by Smout and colleagues (25), in which they addressed the percentage of time the pH was Ͻ4 in a group of individuals ranging in age from 45 to 73 yr (mean 61 yr). They clearly noted a strong relationship between advancing age and esophageal acid contact time.…”

Section: Gastroesophageal Reflux Diseasementioning

confidence: 99%

IV. Clinical and physiological aspects of gastrointestinal motility and aging

Orr

Chen²

2002

American Journal of Physiology-Gastrointestinal and Liver Physi

100

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Control of the GI Tract. IV. Clinical and physiological aspects of gastrointestinal motility and aging. Am J Physiol Gastrointest Liver Physiol 283: G1226-G1231, 2002; 10.1152/ajpgi.00276. 2002.-The gastrointestinal motility changes that occur as a function of age are reviewed herein. Careful attention must be given in any review of aging phenomena to exclude, or at least be cognizant of, the many comorbid conditions that can alter physiological functioning in older adults. The dramatic increase in life expectancy over the past 10-15 years demands that clinicians be aware of the various physiological and clinically relevant changes that occur with age. Gastrointestinal motility changes associated with age are relatively subtle, and in many instances only conflicting data exist. As the older adult population increases, and as the control of disease is improved, much more work needs to be done to understand the true effects of aging on gastrointestinal functioning.gastroesophageal reflux disease; dysphagia; lower esophageal sphincter; incontinence LIFE EXPECTANCY HAS INCREASED dramatically over the past 10-15 years, and the population of individuals over 65 yr old is expected to more than double by the year 2050. The projected rise in the number of Americans over the age of 85 yr is expected to increase from 4 to 18 million over a similar interval of time. As life span increases, the probability increases that individuals will acquire chronic and debilitating diseases such as osteoarthritis, Parkinson's disease, and other neurological conditions, and the risk of stroke and its debilitating sequelae is also increased. These conditions are all associated with gastrointestinal (GI) complications, particularly those related to the esophagus and swallowing. Thus age-related changes in GI functioning can be categorized in terms of those associated with these comorbid conditions of aging or those associated with the aging process itself.Relatively little work has been done to describe the GI changes associated with aging, largely due to the invasive nature of the procedures required. Thus in many instances there is a dearth of normative data on which to base clinical comparisons. For example, very little work has been done to describe normal colonic functioning, and only a few studies have been published that described normative parameters of esophageal peristalsis and lower esophageal sphincter (LES) functioning. Similar limitations apply to gastric and small bowel functioning. Studies that have been done commonly reveal conflicting results due to differences in the technology used (i.e., manometric vs. radiographic). In addition, the manometric techniques that are used vary considerably, with only the more recent studies using intraluminal solid-state transducers, which allow a much more sophisticated assessment of pressure changes compared with those that were acquired or described using more conventional and commonly applied perfusion pressure technology. These issues preclude definitive statements regarding GI func...

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Physiological gastroesophageal reflux and esophageal motor activity studied with a new system for 24-hour recording and automated analysis

Cited by 153 publications

References 14 publications

Successful oesophageal pH monitoring with a catheter‐free system

Successful oesophageal pH monitoring with a catheter‐free system

Normal 24-hour Ambulatory Esophageal pH Values in Koreans

IV. Clinical and physiological aspects of gastrointestinal motility and aging

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