“…Cytological studies have taken some exceptions to the genetic uniformity of somatic cells of the differentiated organism, but have not thereby contributed affirmatively to a comprehensive theory of development (83,121,220). Although the pertinence of extranuclear heredity for ontogeny has been generally accepted, in the absence of extensive evidence for it, plausible theories of development have been constructed which rely on the ultimate primacy of the nucleus (73,131,193,202,220). For technical reasons, cell genetics is best studied in organisms whose germ and soma are not irreversibly differentiated, especially in the microorganisms where vegetative proliferation is preeminent.…”