Physiological insight into the high-altitude adaptations in domesticated yaks (Bos grunniens) along the Qinghai-Tibetan Plateau altitudinal gradient

Ding, Xuezhi; Liang, Chunnian; Guo, Xian; Wu, Xiaoyun; Wang, H.B.; Johnson, K.A.; Yan, Ping

doi:10.1016/j.livsci.2014.01.012

Cited by 49 publications

(35 citation statements)

References 24 publications

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“…These results are consistent with the energy shift from fatty acid oxidation to glucose oxidation Manuscript to be reviewed and glycolysis in the high-altitude living conditions (Ding et al 2014;Ge et al 2012).…”

Section: De Mirnas Are Associated With Hypoxia-related Functionssupporting

confidence: 81%

Peer Review #3 of "Comparative analysis of the microRNA transcriptome between yak and cattle provides insight into high-altitude adaptation (v0.1)"

2017

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Extensive and in-depth investigations of high-altitude adaptation have been carried out at the level of morphology, anatomy, physiology and genomics, but few investigations focused on the roles of microRNA (miRNA) in high-altitude adaptation. We examined the differences in the miRNA transcriptomes of two representative hypoxia-sensitive tissues (heart and lung) between yak and cattle, two closely related species that live in high and low altitudes, respectively. In this study, we identified a total of 808 mature miRNAs, which corresponded to 715 pre-miRNAs in the two species. The further analysis revealed that both tissues showed relatively high correlation coefficient between yak and cattle, but a greater differentiation was present in lung than heart between the two species. In addition, miRNAs with significantly differentiated patterns of expression in two tissues exhibited cooperation effect in high altitude adaptation based on miRNA family and cluster. Functional analysis revealed that differentially expressed miRNAs were enriched in hypoxia-related pathways, such as the HIF-1α signaling pathway, the insulin signaling pathway, the PI3K-Akt signaling pathway, nucleotide excision repair, cell cycle, apoptosis and fatty acid metabolism, which indicated the important roles of miRNAs in high altitude adaptation. These results suggested the diverse degrees of miRNA transcriptome variation in different tissues between yak and cattle, and suggested extensive roles of miRNAs in high altitude adaptation.

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Section: De Mirnas Are Associated With Hypoxia-related Functionssupporting

confidence: 81%

Peer Review #3 of "Comparative analysis of the microRNA transcriptome between yak and cattle provides insight into high-altitude adaptation (v0.1)"

2017

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“…The degree of energy metabolism and pH drop after slaughter affects the quality characteristics of meat (Men, Deng, Tao, Qi, & Xiu, ; Scheffler, Kasten, England, Scheffler, & Gerrard, ). The myoglobin content in the high‐altitude yak skeletal muscle was higher than that of low‐altitude bovine (Ding et al, ). However, the regulatory role of energy metabolism in meat quality of different altitude bovines remains to be further studied.…”

Section: Introductionmentioning

confidence: 99%

Study on the effect of CaMKKβ‐mediated AMPK activation on the glycolysis and the quality of different altitude postmortem bovineslongissimusmuscle

et al. 2019

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This study investigated the activity of adenosine monophosphate‐activated protein kinase (AMPK), glycolysis, and meat quality index in three altitude bovines during postmortem aging process. Local cattle (altitude:1,500 m), Gannan yak (3,000 m), and Yushu yak (4,500 m) postmortem Longissimus Dorsi (LD) muscle were used. Results indicated that CaCl2 significantly increased the AMPK activity by increasing the calcium‐regulated protein kinase kinase (CaMKKβ) activity. Besides, AMPK activation enhanced the activity of lactate dehydrogenase (LDH) and Ca2+‐ATPase and accelerated the rate of muscle maturation during postmortem aging. Moreover, the expression of HIF‐1, PRKAA2, and GLUT4 genes in high‐altitude Yushu yak was higher than that of low‐altitude bovines. CaCl2 activates AMPK by activating CaMKKβ cascade and accelerates postmortem glycolysis affecting the intramuscular environment, color, and muscle protein degradation to accelerate postmortem muscle maturation, suggesting that AMPK has essential effects on postmortem muscle glycolysis and quality, and can regulate muscle quality by regulating postmortem muscle AMPK activity. Practical applications Insufficient postmortem glycolysis usually leads to DFD (dark, firm, and dry) meat. Beef have relatively high incidences of DFD meat, which has an unattractive dark color and causes significant loss to the meat industry. Therefore, AMPK, which can regulate postmortem glycolysis to affect meat quality, is a valid research target.

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“…Under hypoxic conditions, the body is under stress, metabolism is strengthened, ATP consumption is increased, the ATP concentration is decreased, the AMP production is increased, and a high concentration of 5'-AMP and AMPK gamma subunits interact to activate AMPK. Ding et al studied the activity of lactate dehydrogenase (LDH) in yaks at three different altitudes, and its activity positively correlated with altitude [4]. LDH is the key enzyme for anaerobic glycolysis, indicating that yaks at higher altitudes are more dependent on energy metabolism [5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Study of the AMP-activated Protein Kinase Role in Energy Metabolism Changes during the Postmortem Aging of Yak Longissimus dorsal

Yang

Han

et al. 2020

Animals

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To explore the postmortem physiological mechanism of muscle, activity of adenosine monophosphate activated protein kinase (AMPK) as well as its role in energy metabolism of postmortem yaks were studied. In this experiment, we injected 5-amino-1-beta-d-furanonyl imidazole-4-formamide (AICAR), a specific activator of AMPK, and STO-609 to observe the changes in glycolysis, energy metabolism, AMPK activity, and AMPK gene expression (PRKA1 and PRKA2) in postmortem yaks during maturation. The results showed that AICAR could increase the expression of the PRKKA1 and PRKAA2 genes, activate AMPK and increase its activity. The effects of AICAR include a lower concentration of ATP, an increase in AMP production, an acceleration of glycolysis, an increase in the lactic acid concentration, and a decrease in the pH value. In contrast, STO-609 had the opposite effect. Under hypoxic adaptation, the activity of the meat AMPK increased, which accelerated glycolysis and metabolism and more effectively regulated energy metabolism. Therefore, this study lays the foundation for establishing a theoretical system of energy metabolism in postmortem yak meat.

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Physiological insight into the high-altitude adaptations in domesticated yaks (Bos grunniens) along the Qinghai-Tibetan Plateau altitudinal gradient

Cited by 49 publications

References 24 publications

Peer Review #3 of "Comparative analysis of the microRNA transcriptome between yak and cattle provides insight into high-altitude adaptation (v0.1)"

Peer Review #3 of "Comparative analysis of the microRNA transcriptome between yak and cattle provides insight into high-altitude adaptation (v0.1)"

Study on the effect of CaMKKβ‐mediated AMPK activation on the glycolysis and the quality of different altitude postmortem bovineslongissimusmuscle

Study of the AMP-activated Protein Kinase Role in Energy Metabolism Changes during the Postmortem Aging of Yak Longissimus dorsal

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