Physiological predictors of leptin vary during menses and ovulation in healthy women

Sylvia, Kristyn E.; Lorenz, Tierney K.; Heiman, Julia R.; Demas, Gregory E.

doi:10.1016/j.repbio.2018.01.011

Cited by 8 publications

(3 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…47 We selected the model that best fit the data using model comparison with Akaike’s Information Criterion. 48 To select the model of best-fit, we used an iterative process in which we explored a number of models, by systematically adding or deleting all explanatory variables and their interaction effects to determine a balance between parsimony of explanation and a good-fitting model. 49 Correlations were assessed using the Pearson r test.…”

Section: Methodsmentioning

confidence: 99%

Age-associated changes in the impact of sex steroids on influenza vaccine responses in males and females

et al. 2019

Self Cite

View full text Add to dashboard Cite

Vaccine-induced immunity declines with age, which may differ between males and females. Using human sera collected before and 21 days after receipt of the monovalent A/Cal/09 H1N1 vaccine, we evaluated cytokine and antibody responses in adult (18–45 years) and aged (65+ years) individuals. After vaccination, adult females developed greater IL-6 and antibody responses than either adult males or aged females, with female antibody responses being positively associated with concentrations of estradiol. To test whether protection against influenza virus challenge was greater in females than males, we primed and boosted adult (8–10 weeks) and aged (68–70 weeks) male and female mice with an inactivated A/Cal/09 H1N1 vaccine or no vaccine and challenged with a drift variant A/Cal/09 virus. As compared with unvaccinated mice, vaccinated adult, but not aged, mice experienced less morbidity and better pulmonary viral clearance following challenge, regardless of sex. Vaccinated adult female mice developed antibody responses that were of greater quantity and quality and more protective than vaccinated adult males. Sex differences in vaccine efficacy diminished with age in mice. To determine the role of sex steroids in vaccine-induced immune responses, adult mice were gonadectomized and hormones (estradiol in females and testosterone in males) were replaced in subsets of animals before vaccination. Vaccine-induced antibody responses were increased in females by estradiol and decreased in males by testosterone. The benefit of elevated estradiol on antibody responses and protection against influenza in females is diminished with age in both mice and humans.

show abstract

Section: Methodsmentioning

confidence: 99%

Age-associated changes in the impact of sex steroids on influenza vaccine responses in males and females

et al. 2019

Self Cite

View full text Add to dashboard Cite

show abstract

“…However, recent information has also recognized the possible engagement of extra-hypothalamic and non-neuronal cell populations in the brain to regulate leptin-associated cardiometabolic mechanisms [2,5,6,100,101]. Other factors, such as sex steroids, cardiovascular hormones, and neuroinflammatory molecules, have also been suggested to interact with leptin in the CNS to affect the whole body cardiometabolic system [6,121,122]. Therefore, multidirectional approaches are necessary to uncover the contribution of central leptin in determining metabolic and cardiovascular fate.…”

Section: Discussionmentioning

confidence: 99%

Temporal Leptin to Determine Cardiovascular and Metabolic Fate throughout the Life

2020

View full text Add to dashboard Cite

Leptin links peripheral adiposity and the central nervous system (CNS) to regulate cardiometabolic physiology. Within the CNS, leptin receptor-expressing cells are a counterpart to circulating leptin, and leptin receptor-mediated neural networks modulate the output of neuroendocrine and sympathetic nervous activity to balance cardiometabolic homeostasis. Therefore, disrupted CNS leptin signaling is directly implicated in the development of metabolic diseases, such as hypertension, obesity, and type 2 diabetes. Independently, maternal leptin also plays a central role in the development and growth of the infant during gestation. Accumulating evidence points to the dynamic maternal leptin environment as a predictor of cardiometabolic fate in their offspring as it is directly associated with infant metabolic parameters at birth. In postnatal life, the degree of serum leptin is representative of the level of body adiposity/weight, a driving factor for cardiometabolic alterations, and therefore, the levels of blood leptin through the CNS mechanism, in a large part, are a strong determinant for future cardiometabolic fate. The current review focuses on highlighting and discussing recent updates for temporal dissection of leptin-associated programing of future cardiometabolic fate throughout the entire life.

show abstract

“…Additionally, women with PCOS are characterized by the occurrence of disturbances in adipokines secreted by the adipose tissue, leptin in particular, the concentration of which is significantly elevated in PCOS women with obesity [10]. Leptin levels vary depending on the phase of the menstrual cycle, which means that it plays a significant role in regulating hormonal balance in women and is essential for the course of ovulation [11]. This adipokine stimulates the pituitary gland to secrete LH and may also activate gonadotropin-releasing hormone receptors in the hypothalamus which, in turn, stimulate LH secretion [12].…”

Section: Introductionmentioning

confidence: 99%

The Influence of Diet on Ovulation Disorders in Women—A Narrative Review

Jurczewska

Szostak-Węgierek

2022

Nutrients

View full text Add to dashboard Cite

Female infertility is commonly due to ovulation disorders. They are mostly related to polycystic ovary syndrome, which is currently viewed as one of the most common endocrine disorders in women of reproductive age. Ovulation-related female fertility is influenced by multiple factors which may include: age, smoking cigarettes, stress, use of psychoactive substances, and physical activity. Moreover, diet-related factors play an important role in the regulation of ovulation. Dietary components that exert a positive influence on ovulation include: carbohydrate products with low glycemic index, plant protein, monounsaturated and polyunsaturated fatty acids, folic acid, vitamin D, antioxidants, and iron. A diet based on the structure of the Mediterranean diet also seems beneficial. Components that have a negative influence mostly include high glycemic index carbohydrates, large amounts of animal protein, saturated fatty acids, and trans fatty acids, which are typically found in the Western model of nutrition. Due to the paucity of studies that presented a direct link between nutrition and the risk of anovulatory infertility, this study aimed to summarize the most recent research on the influence of dietary factors on ovulation disorders and indicate the possibilities of future research.

show abstract

Physiological predictors of leptin vary during menses and ovulation in healthy women

Cited by 8 publications

References 35 publications

Age-associated changes in the impact of sex steroids on influenza vaccine responses in males and females

Age-associated changes in the impact of sex steroids on influenza vaccine responses in males and females

Temporal Leptin to Determine Cardiovascular and Metabolic Fate throughout the Life

The Influence of Diet on Ovulation Disorders in Women—A Narrative Review

Contact Info

Product

Resources

About