Physiological profile of juvenile rats: effects of cage size and cage density

Yıldız, Ahmet; Hayırlı, A.; Okumuş, Zafer; Kaynar, Özgür; Kisa, Fikrullah

doi:10.1038/laban0207-28

Cited by 23 publications

(2 citation statements)

References 33 publications

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“…Depression is explained by increased protein catabolism and restrained food consumption. A crowded environment compromises physical activity and growth and causes depression in body and organ weights, which is associated with mortality (Mering et al, 2001;Yildiz et al, 2007). In the present study, the weights of the stomach, brain, and testes increased, whereas the liver, spleen, heart, intestine and kidney weights decreased in Tr compared with C. In addition, stressed rats fed with EOM had increased weights of brain, intestines, liver, stomach, and testes (P <0.05).…”

Section: Resultssupporting

confidence: 43%

Role of essential oils in antioxidant capacity and immunity in a rat model of mixed stress

Seyidoğlu¹,

Köşeli²,

Gurbanlı³

et al. 2021

SA J. An. Sci.

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Animal wellbeing is a balance between environmental stress and nutrition that regulates homeostasis. Augmentation of animal feed with essential oils can promote homeostasis. The present study was designed to observe the biochemical, immunological, and biological effects of daily administration of a mixture of essential oils (EOM) in a stressed rat model. Forty-eight adult male Sprague Dawley rats were randomly allocated to four groups, namely a control group (C), a stressed group (S), a treated group (Tr), and a stressed group that received the treatment (TrS). The treatment was applied by adding EOM to the water (0.2 ml/l) three days per week for 28 days. Two chronic stressors (isolation and crowding) were applied to animals in groups S and TrS. Total oxidant status (TOS) increased in the S group compared with C, whereas it decreased when fed with EOM. Although TOS was the same in S and C, it increased in Tr compared with C. There was a significant increase in interleukin 4 (IL-4) in S compared with C, and EOM reversed the IL-4 level. Nevertheless, an increase was seen in the weights of the liver, intestine, brain, and testes in TrS compared with S. The increase in water intake was a result of stress, but feeding with EOM decreased water consumption gradually. This study showed that 0.2 ml/l EOM had protective effects on antioxidant status, immunity and liver function, and decreased water consumption under stress conditions.

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Section: Resultssupporting

confidence: 43%

Role of essential oils in antioxidant capacity and immunity in a rat model of mixed stress

Seyidoğlu¹,

Köşeli²,

Gurbanlı³

et al. 2021

SA J. An. Sci.

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“…However, some researchers suggest that the control of thermal stress caused by animal metabolism needs the animal burden of 1% -2% of the chamber (30). Recently, many studies are implemented on determining the space needed for the lab animals housing and its effective factors (47)(48)(49)(50)(51)(52). Usually, the space necessary to keep animals is determined based on the weight, age, and gender of the animals (53).…”

Section: Discussionmentioning

confidence: 99%

Particulate Matter Inhalation Exposure Chambers and Parameters Affecting Their Performance: A Systematic Review Study

2019

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Exposure to inhalation aerosols and particulate matter (PM) in different concentrations can increase the risk of respiratory, cardiovascular, and other related diseases. The inhalation exposure studies are implemented to assess the biological effects of these hazardous agents in human or animal models, in whole-body (WB) or nose/head-only conditions. Several factors can affect the performance of the inhalation exposure chambers and if left uncontrolled, the results may not be desirable. The current study reviewed the characteristics, structures, and factors affecting the performance of the WB chambers, especially the ones designed for small animal exposure to the PM. At the primary stage, the criteria and the search strategy were determined and the keywords were searched in the scientific electronic databases. Totally, 1051 articles were extracted in the first stage, and finally seven articles were adopted. The technical and design details, materials, coefficient variations (CVs) of concentration, assessment methods, type and number of laboratory animals, procedure, and animals housing conditions were extracted from the selected articles. Then the most desirable WB inhalation exposure chamber was determined based on the criteria for assessing the presented exposure chambers such as the animal housing and least CVs of the concentration in the respiratory zones of the animals under study. It was concluded that the Kimmel design was the best and the most desirable chamber structurally and geometrically, since the concentration of the particle (NaCl) injected into the chamber varied from 3.5% to 5.2%, under standard conditions.

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The laboratory rat

de Boer,

Koolhaas

2024

The UFAW Handbook on the Care and Management of Laboratory and Other Research Animals

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Physiological profile of juvenile rats: effects of cage size and cage density

Cited by 23 publications

References 33 publications

Role of essential oils in antioxidant capacity and immunity in a rat model of mixed stress

Role of essential oils in antioxidant capacity and immunity in a rat model of mixed stress

Particulate Matter Inhalation Exposure Chambers and Parameters Affecting Their Performance: A Systematic Review Study

The laboratory rat

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