Physiological reactivity to acute mental stress in essential hypertension—a systematic review

Walther, Lisa-Marie; Wirtz, Petra H.

doi:10.3389/fcvm.2023.1215710

Cited by 7 publications

(2 citation statements)

References 194 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…According to the literature, triglycerides are mainly stored in adipocytes, and hydrolyzed to free fatty acids by adipocyte triglyceride lipase (ATGL) [55]. The mentioned reactions are altered among patients with OSA: oxidative stress increases activation of ATGL, resulting in an increased level of free fatty acids in the bloodstream [56]. Moreover, intermittent hypoxia, which is a stress factor for the organism, stimulates the adrenal gland with consequent noradrenaline and cortisol release, which also stimulates lipolysis [57].…”

Section: Discussionmentioning

confidence: 99%

Selected routine laboratory tests in the clinical assessment of patients with obstructive sleep apnea

Mosiewicz,

Brożyna-Tkaczyk,

Reichert

et al. 2023

Ann Agric Environ Med.

View full text Add to dashboard Cite

Introduction, Obstructive sleep apnea (OSA) is a chronic disease characterized by repetitive complete or partial occlusion of the upper airways during sleep with respiratory muscle effort, which leads to consecutive apneas and hypopneas. Obstruction of the upper airways during sleep leads to repetitive episodes of disrupted airflow and consequent changes in blood oxygenation, resulting in hypoxaemia and hypercapnia. Intermittent hypoxaemia induces the production of proinflammatory factors and promotes metabolic dysregulation and platelet aggregation. Objective. The main aim of this study was to determine differences, if any, in selected standard parameters in routine laboratory tests often used in GP practice between patients with obstructive sleep apnea, without comorbidities, and a well-defined control group with the absence of this syndrome proven in polygraphic examination. Materials and method. Of the 192 clinically assessed persons with suspected OSA and admitted to the Internal Medicine Department in Lublin, 85 were qualified for the study after application of exclusion criteria. Demographic and health behaviour-related data, medical history regarding sleep habits and cardiovascular disease, were collected from each patient. Results. Apart from significantly higher MCV and MCH among the cpontrol group, no significant differences were found between patients with obstructive sleep apnea and the control group. Conclusions. The results can be useful for the holistic assessment of the health status of patients with newly-diagnosed OSA.

show abstract

Section: Discussionmentioning

confidence: 99%

Selected routine laboratory tests in the clinical assessment of patients with obstructive sleep apnea

Mosiewicz,

Brożyna-Tkaczyk,

Reichert

et al. 2023

Ann Agric Environ Med.

View full text Add to dashboard Cite

show abstract

“…The European Agreement on Work-Related Stress defines stress as a state characterized by physical, psychological, or social complaints or dysfunctions resulting from individuals feeling unable to meet the demands or expectations placed upon them (Broughton, 2004). This definition underscores the global recognition of health-related problems associated with stress (Fisch et al, 2020a;Gnall et al, 2023;Mazure et al, 2023;Popescu et al, 2023;Sara et al, 2023;Walther and Wirtz, 2023). In Germany, a survey of 1,200 adults found that 61% reported experiencing stress either frequently or occasionally (Wohlers and Hombrecher, 2016).…”

Section: Introductionmentioning

confidence: 98%

The relevance of outcome expectations in group hypnosis for stress reduction: a secondary analysis of a multicenter randomized controlled trial

Siewert,

Teut,

Brinkhaus

et al. 2024

Front. Psychol.

View full text Add to dashboard Cite

BackgroundThere is evidence that patients’ positive outcome expectations prior to study interventions are associated with better treatment outcomes. Nevertheless, to date, only few studies have investigated whether individual outcome expectations affect treatment outcomes in hypnosis.ObjectiveTo examine whether outcome expectations to hypnosis prior to starting treatment were able to predict perceived stress, as measured on a visual analog scale (VAS), after 5 weeks.MethodsWe performed a secondary data analysis of a multicenter randomized controlled trial of intervention group participants only. Study participants with stress symptoms were randomized to 5 weekly sessions of a group hypnosis program for stress reduction and improved stress coping, plus 5 hypnosis audio recordings for further individual practice at home, as well as an educational booklet on coping with stress. Perceived stress for the following week was measured at baseline and after 5 weeks using a visual analog scale (0–100 mm; VAS). Hypnosis outcome expectations were assessed at baseline only with the Expectations for Treatment Scale (ETS). Unadjusted and adjusted linear regressions were performed to examine the association between baseline expectations and perceived stress at 5 weeks.ResultsData from 47 participants (M = 45.02, SD = 13.40 years; 85.1% female) were analyzed. Unadjusted (B = 0.326, t = 0.239, p = 0.812, R2 = 0.001) and adjusted (B = 0.639, t = 0.470, p = 0.641, R2 = 0.168) linear regressions found that outcome expectations to hypnosis were not associated with a change in perceived stress between baseline and after 5 weeks in the intervention group.ConclusionOur findings suggest that the beneficial effect of group hypnosis in distressed participants were not associated with outcome expectations. Other mechanisms of action may be more important for the effect of hypnosis, which should be explored in future research.Clinical trial registration: ClinicalTrials.gov, identifier NCT03525093.

show abstract

Stress-Induced Hypercoagulability: Insights from Epidemiological and Mechanistic Studies, and Clinical Integration

von Känel

2024

Semin Thromb Hemost

View full text Add to dashboard Cite

By integrating findings from comprehensive reviews, meta-analyses, and cutting-edge genetic studies, this article illuminates the significance of stress-induced hypercoagulability in clinical medicine. In particular, the findings from numerous prospective cohort studies indicate that stress and hemostatic factors of a hypercoagulable state are associated with increased incident risk and poor prognosis for atherosclerotic cardiovascular disease and venous thromboembolism. Mendelian randomization studies suggest that these associations are partially causal. The review synthesizes extensive research on the link between acute and chronic stress and hypercoagulability, outlining a potential pathway from stress to thrombosis risk. Consistent with the allostatic load concept, acute stress-induced hypercoagulability, initially adaptive, can turn maladaptive under chronic stress or excessive acute stress, leading to arterial or venous thrombotic events. Individuals with predisposing factors, including atherosclerosis, thrombophilia, or immobilization, may exhibit an increased risk of thrombotic disease during stress. Contextual sociodemographic characteristics, the stress experience, and coping resources additionally modulate the extent of stress-induced hypercoagulability. Research into the neuroendocrine, cellular, and molecular bases reveals how stress influences platelet activation coagulation and fibrinolysis. The activation of the sympathetic nervous system and the hypothalamic–pituitary–adrenal axis, along with vagal withdrawal, and the effects of catecholamines, cortisol, and vasopressin, are the central mechanisms involved. Hemoconcentration, inflammation, endothelial dysfunction, and thrombopoiesis additionally contribute to stress-induced hypercoagulability. Further research is needed to prove a causal link between chronic stress and hypercoagulability. This includes exploring its implications for the prevention and management of thrombotic diseases in stressed individuals, with a focus on developing effective psychosocial and pharmacological interventions.

show abstract

Physiological reactivity to acute mental stress in essential hypertension—a systematic review

Cited by 7 publications

References 194 publications

Selected routine laboratory tests in the clinical assessment of patients with obstructive sleep apnea

Selected routine laboratory tests in the clinical assessment of patients with obstructive sleep apnea

The relevance of outcome expectations in group hypnosis for stress reduction: a secondary analysis of a multicenter randomized controlled trial

Stress-Induced Hypercoagulability: Insights from Epidemiological and Mechanistic Studies, and Clinical Integration

Contact Info

Product

Resources

About