Physiological response to the odorant TMT in fully fed and calorically restricted laboratory mice

Chan, Cordelia E.; Lee, Yang U.; Swoap, Steven J.

doi:10.1016/j.jtherbio.2020.102819

Cited by 6 publications

(3 citation statements)

References 35 publications

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“…We show the dynamics of CORT secretion in the mice exposed to TMT for 1 hour as well as during the postexposure period. We observed a significant increase in CORT 30 minutes into TMT exposure compared with baseline CORT levels in the control group; this observation concurs with a recent study collecting single terminal blood samples after 30 minutes of TMT exposure in mice ( 52 ). In the present study, CORT levels continued to rise for the remaining duration of TMT exposure; this TMT-induced rise in CORT was maintained for at least 1 hour after termination of the predator odor stress, indicating prolonged HPA axis activation, which has been observed with prolonged restraint stress in mice ( 54 ).…”

Section: Discussionsupporting

confidence: 92%

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Urocortin3 in the Posterodorsal Medial Amygdala Mediates Stress-induced Suppression of LH Pulsatility in Female Mice

Ivanova

McIntyre

et al. 2021

Endocrinology

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Psychosocial stress disrupts reproduction and interferes with pulsatile LH secretion. The posterodorsal medial amygdala (MePD) is an upstream modulator of the reproductive axis and stress. Corticotropin-releasing factor type-2 receptors (CRFR2) are activated in the presence of psychosocial stress together with increased expression of the CRFR2 ligand Urocortin3 (Ucn3) in the MePD of rodents. We investigate whether Ucn3 signalling in the MePD is involved in mediating the suppressive effect of psychosocial stress on LH pulsatility. Firstly, we administered Ucn3 into the MePD and monitored the effect on LH pulses in ovariectomised mice. Next, we delivered Astressin2B, a selective CRFR2 antagonist, intra-MePD in the presence of predator odor, 2,4,5-Trimethylthiazole (TMT) and examined the effect on LH pulses. Subsequently, we virally infected Ucn3-cre-tdTomato mice with inhibitory DREADDs targeting MePD Ucn3 neurons while exposing mice to TMT or restraint stress and examined the effect on LH pulsatility as well as corticosterone release. Administration of Ucn3 into the MePD dose-dependently inhibited LH pulses and administration of Astressin2B blocked the suppressive effect of TMT on LH pulsatility. Additionally, DREADDs inhibition of MePD Ucn3 neurons blocked TMT and restraint stress-induced inhibition of LH pulses and corticosterone release. These results demonstrate for the first time that Ucn3 neurons in the MePD mediate psychosocial stress-induced suppression of the GnRH pulse generator and corticosterone secretion. Ucn3 signalling in the MePD plays a role in modulating the hypothalamic-pituitary-ganadal and hypothalamic-pituitary-adrenal axes, and this brain locus may represent a nodal centre in the interaction between the reproductive and stress axes.

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Section: Discussionsupporting

confidence: 92%

“…TMT is known to increase HPA axis activity and significantly elevate CORT secretion in mice ( 52 , 53 ). We show the dynamics of CORT secretion in the mice exposed to TMT for 1 hour as well as during the postexposure period.…”

Section: Discussionmentioning

confidence: 99%

Urocortin3 in the Posterodorsal Medial Amygdala Mediates Stress-induced Suppression of LH Pulsatility in Female Mice

Ivanova

McIntyre

et al. 2021

Endocrinology

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“…通过嗅觉系统检测的危险信号有捕食者的分泌物（如粪便、尿液）、攻击性或受威胁的同物种释放的警觉信息素等，均会诱发动物产生强烈的恐惧情绪［ 1 ， 9 - 10 ］。目前对嗅觉恐惧神经环路的研究多数使用狐狸尿液、TMT和2MT ［ 11 - 13 ］。TMT和2MT均能模拟天敌气味，且可以稳定诱导啮齿类动物产生冻结行为，多用于先天性恐惧研究 [ 14 - 16 ] 。…”

Section: 嗅觉信号诱导的先天性恐惧防御行为神经环路unclassified

Advances in neural circuits of innate fear defense behavior

Zhao¹,

Song²,

Wu³

et al. 2023

J Zhejiang Univ (Med Sci)

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恐惧是危险刺激诱发的一种负性情绪，过度恐惧会诱发精神障碍类疾病。对先天性恐惧的神经环路进行解析有助于理解相关精神疾病的病理生理机制。目前，关于先天性恐惧的研究主要基于嗅觉、视觉、听觉等不同感官信号刺激的应答反应机制，而不同类型恐惧信号输入由不同的神经环路调控。主嗅系统和副嗅系统神经回路接收并处理嗅觉刺激信息从而介导冻结等防御反应，视觉刺激信号诱发的逃跑行为主要通过上丘和下丘脑投射回路调控，而听觉刺激信息引发的逃跑等反应主要由听觉皮层投射回路介导。本文综述了视觉、听觉、嗅觉等系统危险刺激投射的神经回路变化，以期为相关精神疾病的诊治提供靶点信息。

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Oxytocin Reduces Sensitized Stress–Induced Alcohol Relapse in a Model of Posttraumatic Stress Disorder and Alcohol Use Disorder Comorbidity

Becker¹,

López²,

King³

et al. 2023

Biological Psychiatry

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Physiological response to the odorant TMT in fully fed and calorically restricted laboratory mice

Cited by 6 publications

References 35 publications

Urocortin3 in the Posterodorsal Medial Amygdala Mediates Stress-induced Suppression of LH Pulsatility in Female Mice

Urocortin3 in the Posterodorsal Medial Amygdala Mediates Stress-induced Suppression of LH Pulsatility in Female Mice

Advances in neural circuits of innate fear defense behavior

Oxytocin Reduces Sensitized Stress–Induced Alcohol Relapse in a Model of Posttraumatic Stress Disorder and Alcohol Use Disorder Comorbidity

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