Physiological responses of dairy animals to recombinant bovine somatotropin: A review

Soliman, Ezzat M.; El-Barody, M. A. A.

doi:10.5897/jcab12.043

Cited by 7 publications

(1 citation statement)

References 75 publications

(151 reference statements)

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“…This product stimulates dry matter intake (DMI) to sustain an increase in t milk production (Dohoo et al, 2003;Paula & Silva, 2011). Therefore, feed intake may vary according to milk production (Soliman & El-Barody, 2014).…”

Section: Introductionmentioning

confidence: 99%

Effect of two recombinant bovine somatotropin formulations on feeding behavior and metabolism of Holstein cows

Teixeira,

Araújo,

Barbosa

et al. 2024

Sem. Ci. Agr.

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This study evaluated the effect of two commercial forms of recombinant bovine somatotropin (rbST; Later® and Fast®; 500 mg) on feed variability, feeding behavior, zootechnical parameters, and milk production of Holstein cows after peak production. Eighteen cows were randomly divided into two groups and treated with injectable of rbST every 14 days for 70 days. Blood samples were collected on day 1, 4, and 7 of each cycle, to assess circulating levels of non-esterified fatty acids (NEFA). Weight and body condition score (BCS) assessments were performed. Milk yields were measured daily using the DelPro™ software (DeLaval®). Feed consumption and feeding behavior was obtained daily using automatic individual feeders (Intergado®). No difference was observed in dry matter intake (DMI) between groups (P=0.07), and no impact was noted on dietary variability (P=0.64). In addition, animals treated with rbST-Fast exhibited more frequent visits to feeders, longer time in consumption, and higher relative DMI (per percentage of live weight) (P<0.01). Animals in the rbST-Fast group produced more milk than those in the rbST-Later group (P=0.03). Furthermore, the weight of the cows was significantly different (P=0.05) between groups. The weight of the rbST-Fast animals was smaller and varied more than thot of the rbST-Later animals (P <0.01). Nonetheless, no difference was noted in BCS (P=0.30) between the groups. The animals in the rbST-Fast group had higher concentrations of NEFA than those in the rbST-Later group (P<0.01). In conclusion, behavioral and metabolic shifts that sustained greater milk production in the cows receiving rbST-Fast. Nonetheless, these shifts are likely linked to lipomobilization and not dietary variability or consumption, as evidenced by the increase in NEFA and greater weight loss in that group.

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Section: Introductionmentioning

confidence: 99%

Effect of two recombinant bovine somatotropin formulations on feeding behavior and metabolism of Holstein cows

Teixeira,

Araújo,

Barbosa

et al. 2024

Sem. Ci. Agr.

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Clinical biochemical and hormonal profiling in plasma: a promising strategy to predict growth hormone abuse in cattle

Doue¹,

Cesbron²,

Stefani

et al. 2015

Anal Bioanal Chem

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Recombinant bovine somatotrophin (rbST) is widely used in some countries to increase milk production. Since 1994, both marketing and use of this substance have been prohibited within the European Union. In this context, the targeted plasma biochemical and hormonal profiling was assessed as a potential screening strategy to highlight rbST (ab)use in cattle. Twenty-one routinely measured clinical blood parameters, representative of main biological profiles (energetic, proteic, etc.), were measured in the plasma of six lactating cows before and after rbST treatment throughout a 23-day study period. Appropriate multivariate statistical analyses [principal component analysis (PCA) and orthogonal partial least square (OPLS)] enabled discriminating animal samples before and after treatment (days 0 vs. 2 to 9, P = 2.10(-9)) and highlighted the five most relevant blood parameters in this discrimination. Based on each five-analyte contribution, a simple mathematically weighted equation was suggested to predict the status of samples. A suspicious threshold was proposed, and the model was further tested with the status prediction of the supplementary samples from untreated (n = 20) and treated cows (n = 22). The calculated false-positive (10%) and false-negative (4.5%) rates were in accordance with the EU requirements for screening methods. Although the model needs to be further validated with additional samples, such targeted plasma biochemical and hormonal profiling already appears as a potential promising screening strategy to highlight rbST (ab)use in cattle.

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Effect of two formulations of recombinant bovine somatotropin on milk production and body condition of cattle under intensive management in Peru

Gómez

Fernández

Franco³

et al. 2022

Trop Anim Health Prod

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The effect of recombinant somatotropin (rbST) application in cattle has been demonstrated in temperate climate but very limited studies are available in tropical regions. The objective of this study was to compare the effect of the application of two different formulations of rbST on the milk yield and body condition of dairy cattle in a commercial herd under intensive production in Peru. We evaluated the application of 500 mg of active rbST in a zinc sesame oil (ZSO-rbST; n = 44) or vitamin E lecithin (VEL-rbST; n = 45) vehicle while control cows (n = 42) did not receive any application. The application of rbST was performed by every 14 days for 12 cycles, for a total of 168 days. The application of rbST increased the milk production of primiparous and multiparous cows by 3 and 3.2 kg/day for the VEL-rbST formulation respectively when compared with control cows (p < 0.01) and no difference in milk production was observed between the ZSO-rbST formulation and the control group (p > 0.05). However, no significant difference on milk production was observed between the rbST formulations evaluated. The effect of rbST per injection cycle indicated differences in milk production and economic return for the 12 cycles between rbST and control in primiparous group, while in multiparous, no differences were found between ZSO-rbST and control (p > 0.05), but differences were observed between VEL-rbST and control in 41% of the cycles (p < 0.05). No differences in body condition were found between the two rbST formulations and the control group during the evaluation. In conclusion, the application of rbST promoted higher milk production of cattle which had a positive impact on the economic income of the farmer.

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Physiological responses of dairy animals to recombinant bovine somatotropin: A review

Cited by 7 publications

References 75 publications

Effect of two recombinant bovine somatotropin formulations on feeding behavior and metabolism of Holstein cows

Effect of two recombinant bovine somatotropin formulations on feeding behavior and metabolism of Holstein cows

Clinical biochemical and hormonal profiling in plasma: a promising strategy to predict growth hormone abuse in cattle

Effect of two formulations of recombinant bovine somatotropin on milk production and body condition of cattle under intensive management in Peru

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