Physiological responses to social and cognitive challenges in 8‐year olds with a history of prenatal cocaine exposure

Kable, Julie A.; Coles, Claire D.; Lynch, Mary Ellen; Platzman, Kathy A.

doi:10.1002/dev.20285

Cited by 24 publications

(36 citation statements)

References 69 publications

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“…Caregiver substance use [76,94] and maternal cocaine use during pregnancy [14,24,27,32,55,75,81,82,93] have been identified as risk factors for adverse child outcomes[45], and both risks are associated with certain environmental conditions known to alter child outcome, including poverty [35] and harsh parenting style [78]. These associations may confound the observed relations between prenatal cocaine exposure and teen cocaine use.…”

Section: Discussionmentioning

confidence: 99%

Prenatal and postnatal cocaine exposure predict teen cocaine use

Delaney‐Black

Chiodo

Hannigan

et al. 2011

Neurotoxicology and Teratology

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Preclinical studies have identified alterations in cocaine and alcohol self-administration and behavioral responses to pharmacological challenges in adolescent offspring following prenatal exposure. To date, no published human studies have evaluated the relation between prenatal cocaine exposure and postnatal adolescent cocaine use. Human studies of prenatal cocaine-exposed children have also noted an increase in behaviors previously associated with substance use/abuse in teens and young adults, specifically childhood and teen externalizing behaviors, impulsivity, and attention problems. Despite these findings, human research has not addressed prior prenatal exposure as a potential predictor of teen drug use behavior. The purpose of this study was to evaluate the relations between prenatal cocaine exposure and teen cocaine use in a prospective longitudinal cohort (n = 316) that permitted extensive control for child, parent and community risk factors. Logistic regression analyses and Structural Equation Modeling revealed that both prenatal exposure and postnatal parent/caregiver cocaine use were uniquely related to teen use of cocaine at age 14 years. Teen cocaine use was also directly predicted by teen community violence exposure and caregiver negativity, and was indirectly related to teen community drug exposure. These data provide further evidence of the importance of prenatal exposure, family and community factors in the intergenerational transmission of teen/young adult substance abuse/use.

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Section: Discussionmentioning

confidence: 99%

Prenatal and postnatal cocaine exposure predict teen cocaine use

Delaney‐Black

Chiodo

Hannigan

et al. 2011

Neurotoxicology and Teratology

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“…For example, prenatal exposures to nicotine [86], cocaine [87], and crystal methamphetamine [88] have been found to disrupt behavioral regulation. Interestingly, these have not been associated with the same degree of neurocognitive deficit as PAE [89].…”

Section: Interactions With Other Drugsmentioning

confidence: 98%

Neurobehavioral Disorder Associated with Prenatal Alcohol Exposure (ND-PAE): Proposed DSM-5 Diagnosis

Kable

O’Connor

Olson

et al. 2015

Child Psychiatry Hum Dev

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107

101

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Over the past 40 years, a significant body of animal and human research has documented the teratogenic effects of prenatal alcohol exposure (PAE). Neurobehavioral Disorder associated with PAE is proposed as a new clarifying term, intended to encompass the neurodevelopmental and mental health symptoms associated with PAE. Defining this disorder is a necessary step to adequately characterize these symptoms and allow clinical assessment not possible using existing physically-based diagnostic schemes. Without appropriate diagnostic guidelines, affected individuals are frequently misdiagnosed and treated inappropriately (often to their considerable detriment) by mental health, educational, and criminal justice systems. Three core areas of deficits identified from the available research, including neurocognitive, self-regulation, and adaptive functioning impairments, are discussed and information regarding associated features and disorders, prevalence, course, familial patterns, differential diagnosis, and treatment of the proposed disorder are also provided.

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“…Sadly, this continued for many years, and the fears were fueled primarily by anecdotal reports and poorly designed studies. Subsequent research failed to replicate most adverse events or found them to be the result of other factors (eg, poor nutrition, inadequate prenatal care, maternal smoking, drinking, and other drug use) [3,4].…”

Section: Introductionmentioning

confidence: 99%

Treatment of Cocaine Abuse During Pregnancy: Translating Research to Clinical Practice

Hull

May

Farrell-Moore

et al. 2010

Curr Psychiatry Rep

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In the late-1980s and early-1990s, much attention in America was focused on cocaine abuse. In particular, the effects of prenatal cocaine use on mothers and infants were in the news spotlight. Risks of adverse effects prompted funding for novel treatment programs. More recently, media attention has shifted elsewhere, and specialized treatment resources have grown scarce. This redirection of funding is unfortunate, as social stigma and fear of legal consequences continue to encourage cocaine-abusing pregnant women to hide drug use and avoid prenatal care. The purpose of this article is to summarize the most prominent adverse maternal and fetal/infant effects associated with prenatal cocaine use; review treatment options, focusing on comprehensive care programs of the 1990s as well as recent research on evidence-based practices and their applicability to pregnant women; and highlight the population of prenatal cocaine-abusing women uninterested in treatment, with a focus on promising strategies to promote drug abstinence and other positive health behaviors.

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Physiological responses to social and cognitive challenges in 8‐year olds with a history of prenatal cocaine exposure

Cited by 24 publications

References 69 publications

Prenatal and postnatal cocaine exposure predict teen cocaine use

Prenatal and postnatal cocaine exposure predict teen cocaine use

Neurobehavioral Disorder Associated with Prenatal Alcohol Exposure (ND-PAE): Proposed DSM-5 Diagnosis

Treatment of Cocaine Abuse During Pregnancy: Translating Research to Clinical Practice

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