Physiological Role of Amyloid Beta in Neural Cells: The Cellular Trophic Activity

Cárdenas-Aguayo, María del Carmen; Silva-Lucero, Maria-del-Carmen; Cortés-Ortiz, Maribel; Jiménez-Ramos, B.; Gómez-Virgilio, Laura; Ramírez-Rodríguez, Gerardo; Arroyo, Edgardo; Fiorentino-Pérez, R.; Garcı́a, Ubaldo; Luna-Muñoz, José; Meraz-Ríos, Marco Antonio

doi:10.5772/57398

Cited by 46 publications

(51 citation statements)

References 116 publications

(134 reference statements)

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“…Amyloid is a protein that is normally found throughout the body. For reasons as yet unknown, in AD, the protein divides indecently, creating a form called beta amyloid, which is toxic to neurons in the [4] brain. Why beta amyloid is formed or why it causes cell death is something nobody knows.…”

Section: Introductionmentioning

confidence: 99%

“…The extracellular deposits of Ab are characteristic of several neurological conditions. One of the major conditions is Alzheimer's disease [4]. Ab is the prime protein in the plaques.…”

Section: Introductionmentioning

confidence: 99%

“…Evidence has been accumulating that the components of the APP processing pathway are involved in non-pathological normal function of the CNS. Below is the schematic of the generation of Ab from APP [4,5].…”

Section: Introductionmentioning

confidence: 99%

“…High levels of Ab reduce long-term potentiation (LTP). Such a type of synaptic plasticity is associated with learning and memory, thus, causing memory loss [4].…”

Section: Introductionmentioning

confidence: 99%

“…This APP is processed by two pathways, viz., an amyloidogenic pathway and a non-amyloidogenic pathway ( Fig. 1) [4]. Amyloid beta is a peptide generated by the amyloidogenic pathway of APP processing.…”

Section: Introductionmentioning

confidence: 99%

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β-Amyloid Biomarker Detection for Alzheimer’s Disease

Grajales

Shuang

et al. 2017

J. Anal. Test.

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Alzheimer's disease (AD) is a neurodegenerative disease. It is a type of dementia and it mainly deals with thinking, memory and behavioral aspects. It is a progressive disease, which in course of time damages most sections of the brain. Beta amyloid peptides (Ab) have been recognized as potential biomarkers to monitor AD. The Ab protein is made up of 39-42 amino acids, which are the main components of the plaques found in the AD brain. This beta amyloid is toxic to the neurons and causes degeneration. In order to measure these biomarkers, nanobiosensing techniques are used. Timely monitoring of Ab levels helps in the detection of the irreversible disease called AD. These techniques fall in two categories, viz., in vitro and in vivo. Several techniques like electrochemical techniques, cantilever-based liposome biosensor, ELISA, PET scan, microdialysis, etc., are discussed further in the article. These techniques can prove to be effective methods for quantifying amyloid deposition within specific brain regions.

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Section: Introductionmentioning

confidence: 99%

“…The extracellular deposits of Ab are characteristic of several neurological conditions. One of the major conditions is Alzheimer's disease [4]. Ab is the prime protein in the plaques.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…High levels of Ab reduce long-term potentiation (LTP). Such a type of synaptic plasticity is associated with learning and memory, thus, causing memory loss [4].…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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β-Amyloid Biomarker Detection for Alzheimer’s Disease

Grajales

Shuang

et al. 2017

J. Anal. Test.

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Structure‐dependent effects of amyloid‐β on long‐term memory in Lymnaea stagnalis

et al. 2017

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Amyloid‐β (Aβ) peptides are implicated in the causation of memory loss, neuronal impairment, and neurodegeneration in Alzheimer's disease. Our recent work revealed that Aβ 1–42 and Aβ 25–35 inhibit long‐term memory (LTM) recall in Lymnaea stagnalis (pond snail) in the absence of cell death. Here, we report the characterization of the active species prepared under different conditions, describe which Aβ species is present in brain tissue during the behavioral recall time point and relate the sequence and structure of the oligomeric species to the resulting neuronal properties and effect on LTM. Our results suggest that oligomers are the key toxic Aβ1–42 structures, which likely affect LTM through synaptic plasticity pathways, and that Aβ 1–42 and Aβ 25–35 cannot be used as interchangeable peptides.

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A Spectroscopic Study on the Amyloid‐β Interaction with Clicked Peptide‐Porphyrin Conjugates: a Vision Toward the Detection of Aβ Peptides in Aqueous Solution

Tosto,

Zimbone,

Sabatino

et al. 2024

ChemBioChem

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Alzheimer’s disease (AD) is a multifactorial form of dementia mainly affecting people in the elderly, but no effective cure is available. According to the amyloid hypothesis the aggregation of Amyloid‐β (Aβ) into oligomeric toxic species is believed to concur with the onset and progression of the disease heavily. By using a click chemistry approach, we conjugated a suitable designed peptide sequence to a metalloporphyrin moiety to obtain three hybrid peptide systems to be studied for their interact ion with Amyloid‐β peptides. The aim is to get new tools for the diagnosis and therapy in AD. The results described in this study, which were obtained through spectroscopic techniques (UV‐Vis, CD, Bis‐Ans and intrinsic porphyrin Fluorescence), Microfluidics (GCI) and cell biology (MTT, Live cell imaging and flow cytometry), reveal interesting features about the structure‐activity relationships connecting these conjugates with the interaction with Aβ, as well as on their potential use as sensing systems. In our opinion the data reported in this paper make the porphyrin‐peptide conjugates highly compelling for further exploration as spectroscopic probes to detect Aβ biomarkers in biological fluids.

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Physiological Role of Amyloid Beta in Neural Cells: The Cellular Trophic Activity

Cited by 46 publications

References 116 publications

β-Amyloid Biomarker Detection for Alzheimer’s Disease

β-Amyloid Biomarker Detection for Alzheimer’s Disease

Structure‐dependent effects of amyloid‐β on long‐term memory in Lymnaea stagnalis

A Spectroscopic Study on the Amyloid‐β Interaction with Clicked Peptide‐Porphyrin Conjugates: a Vision Toward the Detection of Aβ Peptides in Aqueous Solution

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