Physiological roles of microglia during development

Pont-Lezica, Lorena; Béchade, Catherine; Belarif-Cantaut, Yasmine; Pascual, Olivier; Bessis, Alain

doi:10.1111/j.1471-4159.2011.07504.x

Cited by 97 publications

(93 citation statements)

References 91 publications

(320 reference statements)

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“…Microglia are absent in the CNS of TGF-β-deficient mice, and they develop defects in glutamate homeostasis and synaptic plasticity (35). It is not yet clear how microglia are distributed throughout the CNS, and several different mechanisms have been proposed for their distribution, such as migration along radial glial cells toward different brain regions or the recruitment of microglia via guidance cues supplied by different brain regions (36). Undisturbed microglial development is tightly coupled to normal physiological function of adult microglia in the CNS, and a slight disturbance in the maturation and expansion of the cell population can have severe effects on the functional properties of the CNS (37).…”

Section: Microglia In Steady Statementioning

confidence: 99%

Microglia in steady state

Kierdorf¹,

Prinz²

2017

Journal of Clinical Investigation

231

179

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Section: Microglia In Steady Statementioning

confidence: 99%

Microglia in steady state

Kierdorf¹,

Prinz²

2017

Journal of Clinical Investigation

231

179

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“…More recently, several groups have focused their attention on the implications of microglial cells that colonize the embryonic telencephalon at the very beginning of its formation in rodent and human (see above; [63,212]). Through local phagocytic activities and the release of various molecules (such as interleukin-1beta or tumor necrosis factor-alpha), microglial cells have been shown to regulate neurogenesis, to participate in axonal and dendritic organizations and pruning [212][213][214][215][216].…”

Section: Serotonin and The Regulation Of Astrocytes And Microglial Cementioning

confidence: 99%

Sculpting Cerebral Cortex with Serotonin in Rodent and Primate

Vitalis¹,

Verney²

2017

Serotonin - A Chemical Messenger Between All Types of Living Cells

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The mammalian cerebral cortex is critical for sensory and motor integrations and, for higher-order cognitive functions. The construction of mammalian cortical circuits involves the coordinated interplay between cellular processes such as proliferation, migration and differentiation of neural and glial cell subtypes followed by accurate connectivity evolving in complexity in primates. Alteration in cortical development may induce the emergence of various pathological traits and behaviours. Among the large array of factors that regulate the assembly of cortical circuits, serotonin (5-HT) plays important role as a developmental signal that impacts on a broad diversity of cellular processes. 5-HT plays distinct roles during specific sensitive periods and is produced from various sources depending on the perinatal stage. Its roles are mediated by more than fourteen 5-HT receptors that are all G-protein coupled receptors except the ionotropic 5-HT type 3A receptor (5-HT 3A ) mediating rapid neuronal activation. Importantly, 5-HT metabolism and signalling are influenced by numerous epigenetic and genetic factors, including nutrition and gut microbiota, perinatal stress, infection and inflammation. In this review, we will recapitulate some evidences showing that dysregulation of 5-HT homeostasis and 5-HT 3A signalling impairs distinct steps of cortical circuit formation leading to the predisposition of the onset of various psychiatric diseases.

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“…However, the immune system is also intimately involved in the development of the CNS, and recently, new roles for microglia have been elucidated that show that far from being merely reactive to injury or disease, they are instructive in synaptic maturation and elimination and plasticity. [47][48][49] Elements of these roles are likely crucial to the postnatal development of spinal nociceptive circuitry; for example, refinement and removal of inappropriate axons and synapses in the superficial dorsal horn. It is important to be biased toward driving this key developmental role before the more characteristic immune (and pronociceptive) role of the adult system to prevent the risk of autoinflammatory responses to normal developmental debris clearance.…”

Section: Neuroimmune Interactionsmentioning

confidence: 99%

Long-Term Consequences of Neonatal Injury

Beggs

2015

Can J Psychiatry

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The maturation of the central nervous system's (CNS's) sensory connectivity is driven by modality-specific sensory input in early life. For the somatosensory system, this input is the physical, tactile interaction with the environment. Nociceptive circuitry is functioning at the time of birth; however, there is still considerable organization and refinement of this circuitry that occurs postnatally, before full discrimination of tactile and noxious input is possible. This fine-tuning involves separation of tactile and nociceptive afferent input to the spinal cord's dorsal horn and the maturation of local and descending inhibitory circuitry. Disruption of that input in early postnatal life (for example, by tissue injury or other noxious stimulus), can have a profound influence on subsequent development, and consequently the mature functioning of pain systems. In this review, the impact of neonatal surgical incision on nociceptive circuitry is discussed in terms of the underlying developmental neurobiology. The changes are complex, occurring at multiple anatomical sites within the CNS, and including both neuronal and glial cell populations. The altered sensory input from neonatal injury selectively modulates neuronal excitability within the spinal cord, disrupts inhibitory control, and primes the immune system, all of which contribute to the adverse long-term consequences of early pain exposure. W W W Conséquences à long terme d'une blessure néonataleLa maturation de la connectivité sensorielle du système nerveux central (SNC) est dictée par les intrants sensoriels propres aux modalités, en début de vie. Pour le système somatosensoriel, ces intrants sont l'interaction physique, tactile avec l'environnement. La circuiterie nociceptive fonctionne au moment de la naissance; cependant, une part considérable de l'organisation et du raffinement de cette circuiterie se produit en période postnatale, avant que la pleine discrimination entre intrants tactiles et nuisibles ne soit possible. Ce raffinement implique la séparation des intrants afférents tactiles et nociceptifs à la corne dorsale de la moelle épinière, et la maturation de la circuiterie inhibitoire locale et descendante. La perturbation de ces intrants en début de vie postnatale (par exemple, par une lésion des tissus ou un autre stimulus nuisible) peut avoir une influence profonde sur le développement subséquent et par conséquent, sur le fonctionnement mature des systèmes de la douleur. Dans cette revue, nous présentons l'impact d'une incision chirurgicale néonatale sur la circuiterie nociceptive, en ce qui concerne la neurobiologie développementale sous-jacente. Les changements sont complexes et se produisent à de multipes sites anatomiques du SNC, incluant des populations cellulaires à la fois neuronales et gliales. Les intrants sensoriels altérés par une blessure néonatale modulent sélectivement l'excitabilité neuronale de la moelle épinière, perturbent le contrôle inhibitoire, et préparent le système immunitaire, et tout cela contribue à des conséquences i...

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Physiological roles of microglia during development

Cited by 97 publications

References 91 publications

Microglia in steady state

Microglia in steady state

Sculpting Cerebral Cortex with Serotonin in Rodent and Primate

Long-Term Consequences of Neonatal Injury

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