Physiological roles of relaxin in prefertilizing activities of spermatozoa

Miah, Abdul Gaffar; Salma, Ummay; Hamano, Koh‐ichi; Schellander, K.

doi:10.1016/j.anireprosci.2015.07.013

Cited by 4 publications

(2 citation statements)

References 103 publications

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“…The luminal content of the tubules is pumped into the urethra early during ejaculation and mixes with sperm. Prostate secretions play an important role in sperm capacitation, which is required to induce full sperm motility and fertilization capacity (Fraser, 1997; Miah, Salma, Hamano, & Schellander, 2015). A key role for the seminal vesicles, which produce about 70% of seminal fluid volume, is to provide fructose as an energy source to power sperm motility (Aumüller & Riva, 1992).…”

Section: The Prostatementioning

confidence: 99%

The Drosophila Accessory Gland as a Model for Prostate Cancer and Other Pathologies

Wilson

Leiblich

Goberdhan

et al. 2017

Current Topics in Developmental Biology

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The human prostate is a gland of the male reproductive tract, which together with the seminal vesicles, is responsible for most seminal fluid production. It is a common site of cancer, and unlike other glands, it typically enlarges in aging men. In flies, the male accessory glands make many major seminal fluid components. Like their human equivalents, they secrete proteins from several conserved families, including proteases, lectins, and cysteine-rich secretory proteins, some of which interact with sperm and affect fertility. A key protein, sex peptide, is not conserved in vertebrates but plays a central role in mediating long-term effects on females after mating. Although postmitotic, one epithelial cell type in the accessory glands, the secondary cell, continues to grow in adults. It secretes microvesicles called exosomes from the endosomal multivesicular body, which, after mating, fuse with sperm. They also appear to affect female postmating behavior. Remarkably, the human prostate epithelium also secretes exosomes, which fuse to sperm in vitro to modulate their activity. Exosomes from prostate and other cancer cells are increasingly proposed to play fundamental roles in modulating the tumor microenvironment and in metastasis. Here we review a diverse accessory gland literature, which highlights functional analogies between the male reproductive glands of flies and humans, and a critical role for extracellular vesicles in allowing seminal fluid to promote male interests within the female. We postulate that secondary cells and prostate epithelial cells use common mechanisms to control growth, secretion, and signaling, which are relevant to prostate and other cancers, and can be genetically dissected in the uniquely tractable fly model.

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Section: The Prostatementioning

confidence: 99%

The Drosophila Accessory Gland as a Model for Prostate Cancer and Other Pathologies

Wilson

Leiblich

Goberdhan

et al. 2017

Current Topics in Developmental Biology

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“…All of these genes fall in the path of implantation and affect the endometrial readiness in embryo acceptance. Because studies have shown that both spermatozoa and semen are effective on pinopods (1,16), in this study, we sought to investigate the effect of sperm on implantation and the genes important for uterine reception.…”

Section: Introductionmentioning

confidence: 99%

Interaction of sperm with endometrium can regulate genes involved in endometrial receptivity pathway in mice: An experimental study

Ajdary

Zandieh

Amjadi

et al. 2020

IJRM

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Background: Many researchers consider implantation and endometrial receptivity as pertinent issues in reproductive science. Although, several experiments have been performed and their results evaluated, yet there is no confirmed evidence about the related factors and the role of sperm in endometrial receptivity. Objective: To investigate the effect of the sperm-endometrium interaction in regulating genes involved in the endometrial receptivity pathway. Materials and Methods: In this experimental study, 10 male and 30 female NMRI mice were included, and half of the male cases were vasectomized. The subjects were divided into two groups as follows; group 1 (case) comprised of 15 females mated with 5 non-vasectomized male mice, while group 2 (control) consisted of 15 females mated with 5 vasectomized males. Cases were sacrificed and assessed after 36 hr and the endometrial tissue was extracted and kept at -80°C until the next use. The expression of the endometrial receptivity pathway genes, including VEGF, HBEGF, FGF2, EGF, LIF, LIFR, HOXA10, MUC1, PGR, and CSF, was examined in both groups. For statistical analysis, an independent samples test (Mean ± SD) was used. Results: The mRNA levels of LIF (p = 0.045), LIFR (p = 0.040), MUC1 (p = 0.032), VEGF (p = 0.022), EFG (p = 0.035), and FGF2 (p = 0.040) were significantly upregulated in the case group compared with the control group. Conclusion: Finally, seminal plasma was observed to be effective in expressing the involved genes in the successful implantation pathway, including LIF, LIFR, MUC1, VEGF, EGF, and FGF2. Key words: Endometrial receptivity, Sperm, Gene expression, Mice.

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