Physiological Stimulation of the Synthesis of Preelastic Fibers in the Dermis of a Patient with Fibrosis

Godoy, José María Pereira de; Godoy, Lívia Maria Pereira de; Godoy, Maria de Fátima Guerreiro; Neto, Dalisio de Santi

doi:10.1155/2021/2666867

Cited by 7 publications

(6 citation statements)

References 15 publications

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“…Currently evaluating the reversal of fibrosis in lower limb lymphedema and the initial results show a general change in the structure of the skin involving the entire extracellular matrix, type I and III collagen fibers, reticular fibers and epidermis as well as a novel cell type that is under analysis: telocytes. Thus, we will soon have confirmed what we have been divulging for years --that it is possible to reverse fibrosis in the treatment of lymphedema [23][24]. The limitation of the study, we believe, was that it did not include patients of the same age, the same type of surgery and post-surgery treatment (radiotherapy, chemotherapy) and similar time that lymphedema developed and to compare volume reduction with TLM (Godoy method) with other MLD techniques.…”

Section: Discussionmentioning

confidence: 85%

Reduction of Arm Lymphedema Using Manual Lymphatic Therapy (Godoy Method)

Godoy¹,

Godoy²,

Godoy³

et al. 2022

Cureus

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Background: The manual lymphatic drainage (MLD) technique used during the early stages following surgical treatment of breast cancer can help prevent the progression of clinical lymphedema. Objective: The objective of this study was to evaluate the effectiveness of manual lymphatic therapy (MLT) (Godoy method) in reducing the development of lymphedema immediately after breast cancer treatment. Method: A randomized, blind, crossover, clinical trial was conducted involving 66 women with breast cancer-related lymphedema (BCRL), who underwent one hour of manual physical therapy and one hour of the control procedure. To evaluate the volume before and after the application of the MLT technique, volumetry, a water displacement technique was used. For statistical analysis, the paired t-test with 5% alpha error by Stats Direct 3(StatsDirect Ltd, Wirral, UK) was used. Results: A significant reduction in the volume of the limb was found in all patients (p-value = 0.0001, paired t-test). Conclusion: MLT is effective in reducing lymphedema after breast cancer treatment.

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Section: Discussionmentioning

confidence: 85%

Reduction of Arm Lymphedema Using Manual Lymphatic Therapy (Godoy Method)

Godoy¹,

Godoy²,

Godoy³

et al. 2022

Cureus

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“…The treatment used in this study showed an important alteration in the proteins of the extracellular matrix involving type I and type III collagen and elastic fibers [ 26 , 27 ]. The development of the fibrotic process in patients with lymphedema involves the accumulation of macromolecules in the interstitial space, and this evolves with changes in extracellular matrix proteins.…”

Section: Discussionmentioning

confidence: 99%

Synthesis and Physiological Remodeling of CD34 Cells in the Skin following the Reversal of Fibrosis through Intensive Treatment for Lower Limb Lymphedema: A Case Report

Godoy

et al. 2023

Dermatopathology

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A novel type of cell underwent identification between 2005 and 2008 and was denominated the “telocyte” in 2010. In 2012, transmission electron microscopy revealed the presence of telocytes in the dermis. The aim of the present study was to report important changes in immunostained CD34 cells following the treatment of lower limb lymphedema using a specific lymphatic therapy technique. A clinical trial involving the evaluation of changes in immunostained CD34 cells in the epidermis and dermis (10 randomly selected histological fields) of a patient before and after intensive treatment for clinical stage II lymphedema was conducted using the Godoy Method, which was adapted to the treatment of skin fibrosis. The evaluation involved the use of the Weibel multi-point morphometric method. Comparisons were performed using the t-test with a 95% significance level. An important increase in CD34 cells was found with redistribution occurring following treatment. The treatment of primary lymphedema of the lower limbs resulted in the clinical reversal of fibrosis and an increase in the number of immunomarked CD34 cells.

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“…The initial results show significant changes in type I and III collagen fibers, reticular fibers, and the epidermis, along with a novel cell type: telocytes [16,17]. Therapeutic progress depends on novel concepts and techniques with better results.…”

Section: Discussionmentioning

confidence: 99%

Multi-segment bioimpedance in the evaluation of treatment for secondary lower limb lymphedema: Gynecological cancer

Godoy

et al. 2023

ELECTRON J GEN MED

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Aim: The present aimed study was to report the mobilization of body fluids after five days of intensive treatment for secondary lower limb lymphedema. Materials and methods: A crossover clinical trial was conducted involving the analysis of changes in intracellular and extracellular fluids in all extremities and the trunk in women with lower limb lymphedema secondary to treatment for gynecological cancer. Evaluations were performed with multi-segment bio impedance analysis before and after intensive treatment using Godoy Method® eight hours per day for five days. Comparisons were made using Wilcoxon signed-ranks test. Results: Significant changes in intracellular and extracellular fluids were found in all extremities and the trunk (p<0.0001 for all comparisons). Conclusion: Intensive Godoy Method® leads to important changes in the distribution of body fluids in the treatment of lower limb lymphedema following treatment for gynecological cancer, with a significant increase in fluids in the upper limbs and trunk as well as significant reductions in the lower limb and in intracellular and extracellular water.

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Physiological Stimulation of the Synthesis of Preelastic Fibers in the Dermis of a Patient with Fibrosis

Cited by 7 publications

References 15 publications

Reduction of Arm Lymphedema Using Manual Lymphatic Therapy (Godoy Method)

Reduction of Arm Lymphedema Using Manual Lymphatic Therapy (Godoy Method)

Synthesis and Physiological Remodeling of CD34 Cells in the Skin following the Reversal of Fibrosis through Intensive Treatment for Lower Limb Lymphedema: A Case Report

Multi-segment bioimpedance in the evaluation of treatment for secondary lower limb lymphedema: Gynecological cancer

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