Physiologically-based toxicokinetic models help identifying the key factors affecting contaminant uptake during flood events

Brinkmann, Markus; Eichbaum, Kathrin; Kammann, Ulrike; Hudjetz, Sebastian; Cofalla, Catrina; Buchinger, Sebastian; Reifferscheid, Georg; Schüttrumpf, Holger; Preuß, Thomas G.; Hollert, Henner

doi:10.1016/j.aquatox.2014.03.021

Cited by 29 publications

(24 citation statements)

References 55 publications

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“…Project house water was founded from the success of previous exploratory research space pathfinder/seed fund projects and boost-fund projects at the RWTH Aachen University that investigated water-related research (i.e., FLOODSEARCH, DioRAMA, ToxBox; Fig. 2; [8, 20–27]). Project house water promotes the interdisciplinary collaboration of scientists conducting innovative and novel research in the areas of flood research and water research in general.…”

Section: Structure Of the Research In Project House Watermentioning

confidence: 99%

Project house water: a novel interdisciplinary framework to assess the environmental and socioeconomic consequences of flood-related impacts

et al. 2017

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Protecting our water resources in terms of quality and quantity is considered one of the big challenges of the twenty-first century, which requires global and multidisciplinary solutions. A specific threat to water resources, in particular, is the increased occurrence and frequency of flood events due to climate change which has significant environmental and socioeconomic impacts. In addition to climate change, flooding (or subsequent erosion and run-off) may be exacerbated by, or result from, land use activities, obstruction of waterways, or urbanization of floodplains, as well as mining and other anthropogenic activities that alter natural flow regimes. Climate change and other anthropogenic induced flood events threaten the quantity of water as well as the quality of ecosystems and associated aquatic life. The quality of water can be significantly reduced through the unintentional distribution of pollutants, damage of infrastructure, and distribution of sediments and suspended materials during flood events. To understand and predict how flood events and associated distribution of pollutants may impact ecosystem and human health, as well as infrastructure, large-scale interdisciplinary collaborative efforts are required, which involve ecotoxicologists, hydrologists, chemists, geoscientists, water engineers, and socioeconomists. The research network “project house water” consists of a number of experts from a wide range of disciplines and was established to improve our current understanding of flood events and associated societal and environmental impacts. The concept of project house and similar seed fund and boost fund projects was established by the RWTH Aachen University within the framework of the German excellence initiative with support of the German research foundation (DFG) to promote and fund interdisciplinary research projects and provide a platform for scientists to collaborate on innovative, challenging research. Project house water consists of six proof-of-concept studies in very diverse and interdisciplinary areas of research (ecotoxicology, water, and chemical process engineering, geography, sociology, economy). The goal is to promote and foster high-quality research in the areas of water research and flood-risk assessments that combine and build off-laboratory experiments with modeling, monitoring, and surveys, as well as the use of applied methods and techniques across a variety of disciplines.

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Section: Structure Of the Research In Project House Watermentioning

confidence: 99%

Project house water: a novel interdisciplinary framework to assess the environmental and socioeconomic consequences of flood-related impacts

et al. 2017

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“…We have successfully used PBTK models to test hypotheses on the physiology of bioconcentration and the distribution of neutral organic contaminants in rainbow trout (Brinkmann et al, 2014b). A PBTK model for the European eel would provide a powerful research tool, facilitating the prediction and understanding of bioconcentration in this species.…”

Section: Introductionmentioning

confidence: 99%

“…Q w : effective respiratory volume, Q c : cardiac output, C insp : inspired chemical concentration, C exp : expired chemical concentration, PPT: poorly perfused tissues, and RPT: richly perfused tissues. Modified fromBrinkmann et al (2014b).…”

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confidence: 98%

A physiologically based toxicokinetic (PBTK) model for moderately hydrophobic organic chemicals in the European eel ( Anguilla anguilla )

Brinkmann

Freese²,

Pohlmann³

et al. 2015

Science of The Total Environment

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“…Wastewater, atmospheric deposition, and petroleum spillage are some of the most important PAH sources. PAHs and their intermediate degradation products have the potential to generate toxic or mutagenic effects in fish [16][17][18] and humans [19]. PAH metabolites in the bile fluid are generally accepted as measures for PAH exposure in fish because of the rapid metabolism of PAH in most vertebrates [3].…”

Section: Introductionmentioning

confidence: 99%

Polycyclic Aromatic Hydrocarbons (PAHs) and Their Influence to Some Aquatic Species

Baali¹,

Yahyaoui²

2020

Biochemical Toxicology - Heavy Metals and Nanomaterials

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Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental pollutants generated primarily during the incomplete combustion of organic materials (e.g., coal, oil, petrol, and wood). Many PAHs have toxic, mutagenic, and/or carcinogenic functions. PAHs are highly lipid soluble which lead to a fast absorption by the gastrointestinal tract of marine mammals. They are immediately distributed in a vast variety of tissues with a notable tendency for localization in body fat. Metabolism of PAHs is obtained via the cytochrome P450-mediated mixed function oxidase system with oxidation or hydroxylation as the first step. PAHs are environmental contaminants that pose significant risk to health of fish. The effect of PAHs on fish is a topic of rising attention in a lot of countries. Different studies using the bile metabolites separated by high-performance liquid chromatography with fluorescence detection were presented. The aim is to compare the levels of PAH metabolites in fish from different areas and fish species. The major metabolite present in all fish was 1-hydroxypyrene. The data confirm the importance of 1-hydroxypyrene as the key PAH metabolite in fish bile and suggest that the European eel is an ideal species for monitoring PAHs.

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Physiologically-based toxicokinetic models help identifying the key factors affecting contaminant uptake during flood events

Cited by 29 publications

References 55 publications

Project house water: a novel interdisciplinary framework to assess the environmental and socioeconomic consequences of flood-related impacts

Project house water: a novel interdisciplinary framework to assess the environmental and socioeconomic consequences of flood-related impacts

A physiologically based toxicokinetic (PBTK) model for moderately hydrophobic organic chemicals in the European eel ( Anguilla anguilla )

Polycyclic Aromatic Hydrocarbons (PAHs) and Their Influence to Some Aquatic Species

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