2016
DOI: 10.1152/jn.00523.2016
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Physiology and anatomy of neurons in the medial superior olive of the mouse

Abstract: The medial superior olive (MSO) is an important brain center that computes sound location by comparing small differences in arrival time at the two ears. The MSO is investigated for its specializations for processing with extreme temporal precision. In mice, the MSO is small and difficult to study; thus utilization of genetic methods in MSO studies has been lacking. We present the first comprehensive study of the murine MSO and show that most features are consistent with more heavily investigated species.

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Cited by 30 publications
(35 citation statements)
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“…Koch et al (2004) show that these channels are expressed in the somatic and dendritic compartments of MSO neurons. Block of Kv3 channels broadens the large action potentials in mice (Fischl et al, 2016). As action potentials in adult gerbil MSO neurons are very small, the presence and function of high voltage-activated potassium channels is unclear.…”
Section: Introductionmentioning
confidence: 99%
“…Koch et al (2004) show that these channels are expressed in the somatic and dendritic compartments of MSO neurons. Block of Kv3 channels broadens the large action potentials in mice (Fischl et al, 2016). As action potentials in adult gerbil MSO neurons are very small, the presence and function of high voltage-activated potassium channels is unclear.…”
Section: Introductionmentioning
confidence: 99%
“…In common laboratory rodents, the three main SOC (LSO, MSO and MNTB) are known targets of the cochlear nuclei and it is likely that a similar connectivity exists in marsupials (Aitkin et al, 1986;Bazwinsky-Wutschke, Hartig, Kretzschmar, & Rubsamen, 2016). The presence of a MSO is not surprising as it is known to persist in almost all mammalian species analysed including the mouse (Fischl et al, 2016;Ollo & Schwartz, 1979). The MSO is involved in detecting interaural timing differences related to sound localization of lower frequencies (Grothe & Sanes, 1994).…”
Section: Discussionmentioning
confidence: 99%
“…Likewise, CB-IR neurons were observed in the medial superior olive (MSO) of the bat [Zettel et al, 1991], whereas CB-IR neurons were not detected in the adult rat [Friauf, 1994], guinea pig [Caicedo et al, 1996], and cat [Adams and Mugnaini, 1990;Matsubara, 1990]. The MSO, which also belongs to the SOC in mice, is smaller and less organized than in many other mammals and is more difficult to distinguish from other nuclei [Fischl et al, 2016]. In mice, the MSO is difficult to identify in anatomical structure and function [Grothe, 2000], even though CaBPs were used as markers.…”
Section: Discussionmentioning
confidence: 99%