2007
DOI: 10.1016/j.semcdb.2007.05.004
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Physiology and electrical activity of uterine contractions

Abstract: Presently, there is no effective treatment for preterm labor. The most obvious reason for this anomaly is that there is no objective manner to evaluate the progression of pregnancy through steps leading to labor, either at term or preterm. Several techniques have been adopted to monitor labor, and/or to diagnose labor, but they are either subjective or indirect, and they do not provide an accurate prediction of when labor will occur. With no method to determine preterm labor, treatment might never improve. Ute… Show more

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Cited by 189 publications
(159 citation statements)
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“…The process of parturition involves a relatively long conditioning (preparatory) phase, followed by a short active labor [29]. During the preparatory phase, excitability of the myometrial cells increases due to the changes in transduction mechanisms and synthesis of several new proteins, including ion channels and receptors for uterotonins.…”
Section: Applications To Uterine Emg Signal Chracterizationmentioning
confidence: 99%
“…The process of parturition involves a relatively long conditioning (preparatory) phase, followed by a short active labor [29]. During the preparatory phase, excitability of the myometrial cells increases due to the changes in transduction mechanisms and synthesis of several new proteins, including ion channels and receptors for uterotonins.…”
Section: Applications To Uterine Emg Signal Chracterizationmentioning
confidence: 99%
“…In most pregnancies, the connections between gap junctions are sparse, although gradually increasing, until the last few days before labour. A specific pacemaker site has not been conclusively identified, although, due to obvious physiological reasons, there may be a generalised propagation direction, from the top to the bottom of the uterus [22].…”
Section: Electrohysterographymentioning
confidence: 99%
“…Let a fasciculus be embedded in the extracellular matrix of connective tissue. Our developments of a biomechanical model will be based on the following assumptions which are consistent with several lines of experimental evidence [3,4]. i) Smooth muscle cells in the fasciculus are connected by tight junctions to form a homogenous electromechanical continuum.…”
Section: Model Formulationmentioning
confidence: 88%