PHYSIOLOGY AND ENDOCRINOLOGY SYMPOSIUM: Biological role of interferon tau in endometrial function and conceptus elongation12

Dorniak, Piotr L.; Bazer, Fuller W.; Spencer, Thomas E.

doi:10.2527/jas.2012-5845

Cited by 99 publications

(99 citation statements)

References 106 publications

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“…Third, inhibition of uterine PGF production prevents spontaneous luteolysis in both ewes and heifers (Lewis and Warren, 1977). Fourth, passive immunization with antibodies that are specific to PGF prolonged the lifespan of the CL (Fairclough et al, 1981). Fifth, there is good evidence that PGF can be efficiently exchanged from the uterine vein to the ovarian artery in sufficient quantities to make the local mechanisms physiologically feasible (Lamond et al, 1973;McCracken et al, 1981).…”

Section: Period Ii: Normal Luteolysis: Role Of Uterus and Pgf -Days 1mentioning

confidence: 99%

“…This calculates to an increase in volume from about 500 µm 3 in the granulosa cell to almost 30,000 µm 3 in the large luteal cell, over a 50-fold increase in cellular volume . In addition, there is rapid and extensive angiogenesis as the avascular follicular antrum remodels into a highly vascularized structure with every large luteal cell adjacent to multiple capillaries (Ellinwood et al, 1978) and the highest blood flow per gram of tissue in the body (Wiltbank et al, 1989). Then, abruptly, at specific, critical times during the cycle or pregnancy, the structure is put to death.…”

Section: Introductionmentioning

confidence: 99%

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Maintenance or regression of the corpus luteum during multiple decisive periods of bovinepregnancy

Wiltbank¹,

Meidan²,

Ochoa³

et al. 2016

Anim Reprod

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In ruminants, there are specific times during the estrous cycle or pregnancy when the corpus luteum (CL) may undergo regression. This review has attempted to summarize the physiological and cellular mechanisms involved in CL regression or maintenance during four distinct periods. The first period is near day 7 when animals that are ovulating after a period of low circulating progesterone (P4), such as first pubertal ovulation or first postpartum ovulation, are at risk of having a premature increase in Prostaglandin F2α (PGF) secreted from the uterus resulting in early CL regression and a short estrous cycle. The second period is when normal luteolysis occurs at day 18-25 of the cycle or when the CL is rescued by interferon-tau secreted by the elongating embryo. The uterine mechanisms that determine the timing of this luteolysis or the prevention of luteolysis have been generally defined. Induction and activation of endometrial E2 receptors result in induction of endometrial oxytocin receptors that can now be activated by normal pulses of oxytocin. Of particular importance is the observation that the primary mechanisms are only activated through local (ipsilateral) and not a systemic route due to transfer of PGF from the uterine vein to the ovarian artery. In addition at the CL level, studies are providing definition to the cellular and molecular mechanisms that are activated in response to uterine PGF pulses or pregnancy. The third period that is discussed occurs in the second month of pregnancy (day 28-60) when undefined mechanisms result in CL maintenance of an ipsilateral CL but regression of a contralateral (opposite side from pregnancy) CL. The final period that is discussed is regression of the CL just prior to parturition. Although, cortisol from the fetus appears to be the primary initiator of luteolysis, PGF seems to be the final signal that causes regression of the CL. Thus, in all four periods, regression of the CL is likely to be caused by the direct actions of PGF that is secreted from the uterus. The uterine mechanisms that result in secretion of PGF seem to be normally inhibited during the early luteal phase, making short luteal phases not a normal event, and are altered during early pregnancy (day 18-25) resulting in prevention of luteolysis. During much of pregnancy, the mechanisms that cause PGF secretion from the uterus in response to oxytocin are intact but luteolysis does not normally occur, perhaps due to lack of efficient utero-ovarian transfer of PGF.

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Section: Period Ii: Normal Luteolysis: Role Of Uterus and Pgf -Days 1mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Maintenance or regression of the corpus luteum during multiple decisive periods of bovinepregnancy

Wiltbank¹,

Meidan²,

Ochoa³

et al. 2016

Anim Reprod

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“…Lymphangiogenesis is also important in the bovine corpus luteum, with lymphangiogenic factors expression particularly in the corpus luteum of mid-cycle as well as early pregnancy . If cattle are pregnant, then interferon tau released by the trophoblast prevents the development of the luteolytic mechanism by inhibiting the expression of the oxytocin receptor gene in the endometrial epithelium, which prevents the release of luteolytic pulses of prostaglandin F 2a (Dorniak et al 2013). Whereas, in the absence of an embryo, prostaglandin F 2a induces luteolysis with the assistance of other inflammatory mediators such as TNFa (Skarzynski & Okuda 2010).…”

Section: Inflammation and Reproductive Physiologymentioning

confidence: 99%

Innate immunity and inflammation of the bovine female reproductive tract in health and disease

Sheldon¹,

Cronin²,

Healey³

et al. 2014

Reproduction

128

100

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Mammalian reproductive physiology and the development of viviparity co-evolved with inflammation and immunity over millennia. Many inflammatory mediators contribute to paracrine and endocrine signalling, and the maintenance of tissue homeostasis in the female reproductive tract. However, inflammation is also a feature of microbial infections of the reproductive tract. Bacteria and viruses commonly cause endometritis, perturb ovarian follicle development and suppress the endocrine activity of the hypothalamus and pituitary in cattle. Innate immunity is an evolutionary ancient system that orchestrates host cell inflammatory responses aimed at eliminating pathogens and repairing damaged tissue. Pattern recognition receptors on host cells bind pathogen-associated molecular patterns and damage-associated molecular patterns, leading to the activation of intracellular MAPK and NFkB signalling pathways and the release of inflammatory mediators. Inflammatory mediators typically include the interleukin cytokines IL1b and IL6, chemokines such as IL8, interferons and prostaglandins. This review outlines the mechanisms of inflammation and innate immunity in the bovine female reproductive tract during health and disease condition.

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“…Comparing endometrial transcriptomes of cows that were recipients of in vivo, IVF-derived or SCNT -embryos revealed distinct patterns of gene expression among the three groups (Bauersachs et al, 2009;Mansouri-Attia et al, 2009b). Moreover, studies show that the supply of numerous amino acids and derivatives was significantly lower in the endometrium of SCNT conceptus-carrying females (Groebner et al, 2011b;Dorniak et al, 2013a).…”

Section: Molecular Response Of Maternal Endometrium To the Embryomentioning

confidence: 96%

Embryo maternal immune interactions in cattle

Fair¹

2016

Anim Reprod

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Mammalian embryo implantation requires the priming of the maternal immune system, but, not the provocation. There are many examples of conditions where a disturbed or aberrant immune profile during embryo implantation leads to pregnancy loss. However, these studies are primarily associated with human and mouse species; data is generally limited for cattle and livestock. Most available information centres on the endometrial response to interferon tau (IFNT), a type I antiviral cytokine, which is the maternal recognition factor for cattle and sheep. Interferon tau secretion by the embryo and detection by the dam is critical to corpus luteum (CL) maintenance and pregnancy retention. However, the large volume of bovine endometrial and conceptual transcriptomic data highlights a broader more integral role of the maternal immune system in the establishment of pregnancy in cattle. When taken together with available immunohistochemistry and flow cytometry data from livestock, mouse, and human, a profile of immune cell involvement from ovulation to conception and placentation emerges. The key events of pregnancy establishment in cattle and the involvement of the maternal immune system will be discussed.

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PHYSIOLOGY AND ENDOCRINOLOGY SYMPOSIUM: Biological role of interferon tau in endometrial function and conceptus elongation12

Cited by 99 publications

References 106 publications

Maintenance or regression of the corpus luteum during multiple decisive periods of bovinepregnancy

Maintenance or regression of the corpus luteum during multiple decisive periods of bovinepregnancy

Innate immunity and inflammation of the bovine female reproductive tract in health and disease

Embryo maternal immune interactions in cattle

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