Physiology and Molecular Biology of Ion Channels Underlying Ventricular Repolarization of the Mammalian Heart

Multimodal imaging shows fibrosis architecture and action potential dispersion are predictors of arrhythmic risk in spontaneous hypertensive rats

“…Age‐related increase in ventricular APD has been observed previously (Botchway et al., 2003; Gao et al., 2016; Jin et al., 2010; Kowey et al., 1991). Prolongation of APD in hypertension is linked with down‐regulation of potassium ion channels that contribute to repolarization (Comollo et al., 2020), principally the transient outward current, I to , in the rat (Cerbai et al., 1994). However, while we also found that mean APD was progressively longer at all pacing rates for older SHRs when data were clustered by age (Fig.…”