Physiology and Pathophysiology of Digestion, Part 3

Granger, D. Neil; Morris, James; Kvietys, Peter R.

doi:10.4199/c00167ed1v03y201806isp084

Cited by 1 publication

(1 citation statement)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…57 The endothelium is also highly sensitive to states of ischemia and hypoxia, with the post-capillary venules being cited as the most susceptible to reperfusion injury. 58,59 Effects of ischemia-and hypoxiainduced endothelial damage include cellular swelling and loss of basement membrane integrity; as a result, the endothelial tight junction integrity is compromised, and the vasculature becomes more permeable or "leaky." As endothelial cells swell, capillary narrow-ing leads to compromised microcirculatory flow.…”

Section: Physiological Complications Of Hemorrhagic Shockmentioning

confidence: 99%

Pathophysiology of hemorrhagic shock

Kuo

Palmer

2022

J Vet Emergen Crit Care

View full text Add to dashboard Cite

Background Hemorrhagic shock is a common condition that may lead to hemodynamic instability, decreased oxygen delivery, cellular hypoxia, organ damage, and ultimately death. Clinical importance This review addresses the pathophysiology of hemorrhagic shock. Hemorrhagic shock can be rapidly fatal and is the leading cause of death in human trauma patients. Understanding the pathophysiology of hemorrhagic shock is imperative in understanding the current hemostatic and resuscitative strategies and is foundational to the development of new therapeutic options. Key Points Shock is a state of inadequate cellular energy production and can be triggered by many causes Both traumatic and non‐traumatic causes of hemorrhage can lead to the development of hemorrhagic shock Prompt recognition and attenuation of hemorrhage is paramount in preventing the onset or potentiation of hemorrhagic shock Acute hemorrhage produces distinct physiological responses depending on the magnitude and rate of hemorrhage. Hemorrhagic shock may be directly related to the initial injury but may also be exacerbated and complicated by a post‐traumatic coagulopathy, termed acute traumatic coagulopathy

show abstract

Section: Physiological Complications Of Hemorrhagic Shockmentioning

confidence: 99%