Physiology and Pathophysiology of Eryptosis

Läng, Florian; Lang, Elisabeth; Föller, Michael

doi:10.1159/000342534

Cited by 145 publications

(121 citation statements)

References 62 publications

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“…Heme is transformed to biliverdin by the enzyme heme-oxigenase (HO) (Maines 1988, Murray 2003, Kikuchi et al 2005. Red blood cell degradation is enhanced in oxidative stress and energy depletion (Lang et al 2012), and oxidative stress also stimulates HO gene expression, and thus increases the transformation of heme to biliverdin (Choi andAlam 1996, Schipper 2004). These findings suggest that birds with higher level of oxidative stress and lower level of energy would produce more biliverdin.…”

Section: Blue-green Eggshell Pigmentationmentioning

confidence: 99%

Effects of food limitation on the intensity of blue‐green and brown eggshell coloration: an experimental study with the canary

Hargitai

Boross

Nyíri

et al. 2017

Journal of Avian Biology

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Variation in blue-green and brown coloration of avian eggshells could be affected by several factors, including environmental nutritional constraints. Better availability of nutrients could influence the synthesis and deposition of pigments into the eggshell, so we may expect a link between the food availability during egg formation, the body condition of the female and intensity of eggshell coloration. This hypothesis has received mixed support so far: in some bird species a positive correlation between female body condition and eggshell blue-green coloration could be demonstrated, but other studies failed to find a significant link. In this study, we experimentally limited the food availability for domestic canaries Serinus canaria prior to and during egg laying, and examined its effects on the biliverdin-and protoporphyrin-based eggshell coloration. Treatment had no significant effect on eggshell blue-green chroma and biliverdin concentration. However, we found a significant positive relationship between female body condition and eggshell background blue-green chroma in the control group, but not in the food restricted group. Females possibly experiencing a decline in antioxidant capacity due to food limitation may not be able to produce a blue-green eggshell colour intensity reliably indicating their body condition. Furthermore, foodrestricted canary females laid eggs with significantly higher eggshell brown chroma, spot intensity, and protoporphyrin concentration. Therefore, our results suggest that limitation in actual nutrient availability increases deposition of protoporphyrin into the eggshell, and it may also modify the association between female body condition and intensity of blue-green eggshell coloration.

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Section: Blue-green Eggshell Pigmentationmentioning

confidence: 99%

Effects of food limitation on the intensity of blue‐green and brown eggshell coloration: an experimental study with the canary

Hargitai

Boross

Nyíri

et al. 2017

Journal of Avian Biology

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“…Some of these pathologies are highly prevalent in patients on hemodialysis (for example, inflammation and changes in vascular smooth muscles and endothelium, processes that accelerate arteriosclerosis) (21,22). Hypoxemia also impairs resilience against reactive oxygen species (ROS) and may increase erythrocyte apoptosis (eryptosis) (23). Noteworthy, in patients with CHF and sleep apnea, it was observed that not only the frequency but also, the time spent with SaO 2 ,90%, the hypoxic burden, is a predictor for hemodynamic stress (24).…”

Section: Introductionmentioning

confidence: 99%

Intradialytic Hypoxemia and Clinical Outcomes in Patients on Hemodialysis

Meyring-Wösten

Zhang

et al. 2016

Clinical Journal of the American Society of Nephrology

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Background and objectives Intradialytic hypoxemia has been recognized for decades, but its associations with outcomes have not yet been assessed in a large patient cohort.Design, setting, participants, & measurements Our retrospective cohort study was conducted between January of 2012 and January of 2015. We recorded blood oxygen saturation every minute during hemodialysis in patients with arteriovenous access. A 6-month baseline period with at least 10 treatments with oxygen saturation measurements preceded a 12-month follow-up. Patients were stratified by the presence or absence of prolonged intradialytic hypoxemia defined as oxygen saturation ,90% for at least one third of the treatment time. Demographic, laboratory, and treatment data and hospitalization and mortality rates were compared between the groups. Multivariate Cox regression analysis was used to assess baseline predictors of all-cause mortality during follow-up.Results In total, 100 (10%) of 983 patients had prolonged intradialytic hypoxemia. These patients were older (+3.6 years; 95% confidence interval, 0.8 to 6.3), had longer dialysis vintage (+1.2 years; 95% confidence interval, 0.3 to 2.1), and had higher prevalence of congestive heart failure (+10.8%; 95% confidence interval, 1.6 to 20.7) and chronic obstructive pulmonary disease (+13%; 95% confidence interval, 5 to 21.2). They also resembled an inflammatory phenotype, with lower serum albumin levels (20.1 g/dl; 95% confidence interval, 20.2 to 0) and higher neutrophil-to-lymphocyte ratios (+1; 95% confidence interval, 0.5 to 1.6). They had lower hemoglobin levels (20.2 g/dl; 95% confidence interval, 20.4 to 0) and required more erythropoietin (+1374 U per hemodialysis treatment; 95% confidence interval, 343 to 2405). During follow-up, all-cause hospitalization (1113 hospitalizations; univariate hazard ratio, 1.46; 95% confidence interval, 1.22 to 1.73) and mortality (89 deaths; adjusted hazard ratio, 1.98; 95% confidence interval, 1.14 to 3.43) were higher in patients with prolonged intradialytic hypoxemia.Conclusions Prolonged intradialytic hypoxemia was associated with laboratory indicators of inflammation, higher erythropoietin requirements, and higher all-cause hospitalization and mortality.

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“…Much evidence points out different environmental conditions, such as diabetes, sepsis and the Mediterranean anemia, chronic renal failure and other diseases may induce eryptosis. 9 In a number of clinical trials, erythrocyte was confirmed that the expectancy was decreased from normal 120 days to about 90 days in uremia. 10 It is also one of the important reasons of renal anemia, including the occurrence of eryptosis frequent.…”

Section: Discussionmentioning

confidence: 97%

L-Carnitine inhibits eryptosis induced by uremic serum and the related mechanisms

Sun

Liu

et al. 2015

Renal Failure

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Objective: To investigate whether L-carnitine (LC) inhibits eryptosis induced by uremic serum and the related mechanism. Methods: One percent erythrocyte suspension was cultured by three kinds of mediums in vitro, which was included in the control group (Group C, phosphate buffered saline [PBS]), the uremic serum group (Group U, 30% uremic serum + 70% PBS) and the LC group (Group L, 30% uremic serum + 70% PBS + 200 umol/L LC), respectively. Erythrocytes were collected at 24 and 48 h, respectively. Phosphatidylserine (PS) was estimated from Annexin-V-binding and reactive oxygen species (ROS) by flow cytometry, glutathione (GSH) was estimated from Enzyme linked immunosorbent assays (ELISA) by Microplate reader. Results: Eryptosis in Group C increased as the incubating time extended (3.43 ± 0.37 at 24 h, 4.21 ± 0.44 at 48 h). Eryptosis increased in Group U compared with Group C (6.5 1 ± 0.71 at 24 h, p50.01; 8.55 ± 0.76 at 48 h, p50.01), while decreased in Group L compared with Group U (5.80 ± 0.69 at 24 h, p50.05; 7.87 ± 0.76 at 48 h, p50.05). Meanwhile, ROS of erythrocytes increased in Group U compared with Group C (33.12 ± 1.61 versus 14.83 ± 2.22 at 24 h, p50.01; 42.06 ± 1.81 versus 20.94 ± 1.78 at 48 h, p50.01), and GSH decreased in Group U compared with Group C (25.66 ± 0.32 versus 31.27 ± 0.38 at 24 h, p50.01; 8.53 ± 0.59 versus 17.29 ± 0.54 at 48 h, p50.01). ROS of erythrocytes decreased in Group L compared with Group C (26.29 ± 1.69 at 24 h, p50.01; 36.21 ± 2.00 at 48 h, p50.01). GSH increased in Group L compared with Group U (27.54 ± 0.60 at 24 h, p50.01; 15.18 ± 0.42 at 48 h, p50.01). Conclusions: LC inhibits eryptosis induced by uremic serum, which possibly relates to oxidative stress in part.

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Physiology and Pathophysiology of Eryptosis

Cited by 145 publications

References 62 publications

Effects of food limitation on the intensity of blue‐green and brown eggshell coloration: an experimental study with the canary

Effects of food limitation on the intensity of blue‐green and brown eggshell coloration: an experimental study with the canary

Intradialytic Hypoxemia and Clinical Outcomes in Patients on Hemodialysis

L-Carnitine inhibits eryptosis induced by uremic serum and the related mechanisms

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