Physiology and pathophysiology of sphingolipid metabolism and signaling

Huwiler, Andrea; Kolter, Thomas; Pfeilschifter, Josef; Sandhoff, Konrad

doi:10.1016/s1388-1981(00)00042-1

Cited by 397 publications

(365 citation statements)

References 397 publications

Supporting

Mentioning

359

Contrasting

Unclassified

Order By: Relevance

“…As already described, endogenous ceramide is generated primarily from sphingomyelin by SMase-induced hydrolysis, and it can also be generated de novo by the action of ceramide synthase [56]. Both ceramide production and ceramide function are involved in reactive oxygen species (ROS), which include H 2 O 2 , superoxide and hydroxyl radicals.…”

Section: Ceramide and Reactive Oxygen Speciesmentioning

confidence: 99%

Ceramide: A common pathway for atherosclerosis?

et al. 2008

View full text Add to dashboard Cite

Plasma sphingomyelin concentration is correlated with the development of atherosclerosis. It has been found to exist in significantly higher concentrations in aortic plaque. This appears to have clinical relevance as well as it has been shown to be an independent predictor of coronary artery disease. Ceramide, the backbone of sphingolipids, is the key component which affects atherosclerotic changes through its important second-messenger role. This paper sheds light on some of the current literature supporting the significance of ceramide with respect to its interactions with lipids, inflammatory cytokines, homocysteine and matrix metalloproteinases. Furthermore, the potential therapeutic implications of modulating ceramide concentrations are also discussed.

show abstract

Section: Ceramide and Reactive Oxygen Speciesmentioning

confidence: 99%

Ceramide: A common pathway for atherosclerosis?

et al. 2008

View full text Add to dashboard Cite

show abstract

“…1,2 Most gangliosides are amphipathic constituents of the outer leaflet of cell membranes, where they are vital for the maintenance of membrane structure and organization. A small proportion (10%) is localized in mitochondria and endoplasmic reticulum (ER).…”

Section: Introductionmentioning

confidence: 99%

“…1 Gangliosides are also key signaling molecules of pivotal biological processes, including cellular recognition and adhesion, receptor signal transduction, growth regulation, and differentiation. [4][5][6] In addition, they are important messengers of the adaptive responses to stress such as apoptosis.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Gangliosides as apoptotic signals in ER stress response

d’Azzo

Tessitore²,

Sano

2006

Cell Death Differ

View full text Add to dashboard Cite

Renewed attention has been given lately to gangliosides and to their function as intracellular messengers of the adaptive responses to stress. Gangliosides are vital components of cell membranes; therefore, deleterious consequences can result from changes in their chemical composition and concentration, that is, membrane dynamics and structure can be altered as can the behavior of other membrane proteins. The importance of gangliosides in human health is evident in neurodegenerative diseases associated with defects in their degradation. As key modulators of intracellular calcium flux, gangliosides are involved in cellular processes downstream of calcium signaling. In this review, we focus on the effect of ganglioside accumulation on the endoplasmic reticulum calcium homeostasis and on the integrity of the mitochondrial membranes. We discuss how these events elicit an apoptotic program that ultimately leads to cell death. Owing to interorganelle crosstalk, these events are not necessarily self-contained, and gangliosides may serve as the common factor.

show abstract

“…Sphingolipids are essential components of all eukaryotic cell membranes, and are required for the survival of Drosophila, yeast, and mammals [1][2][3][4]. The biological and clinical importance of sphingolipid metabolism was revealed by the discovery that diseases such as Gaucher's disease and Niemann-Pick were caused by defective sphingolipid degradation.…”

Section: Introductionmentioning

confidence: 99%

Sphingolipids and membrane biology as determined from genetic models

Rao

Acharya

2008

Prostaglandins & Other Lipid Mediators

View full text Add to dashboard Cite

The importance of sphingolipids in membrane biology was appreciated early in the twentieth century when several human inborn errors of metabolism were linked to defects in sphingolipid degradation. The past two decades have seen an explosion of information linking sphingolipids with cellular processes. Studies have unraveled mechanistic details of the sphingolipid metabolic pathways, and these findings are being exploited in the development of novel therapies, some now in clinical trials. Pioneering work in yeast has laid the foundation for identifying genes encoding the enzymes of the pathways. The advent of the era of genomics and bioinformatics has led to the identification of homologous genes in other species and the subsequent creation of animal knock-out lines for these genes. Discoveries from these efforts have re-kindled interest in the role of sphingolipids in membrane biology. This review highlights some of the recent advances in understanding sphingolipids' roles in membrane biology as determined from genetic models.

show abstract

Physiology and pathophysiology of sphingolipid metabolism and signaling

Cited by 397 publications

References 397 publications

Ceramide: A common pathway for atherosclerosis?

Ceramide: A common pathway for atherosclerosis?

Gangliosides as apoptotic signals in ER stress response

Sphingolipids and membrane biology as determined from genetic models

Contact Info

Product

Resources

About