Physiology of Erection and Pharmacological Management of Impotence

Lue, Tom F.; Tanagho, Emil A.

doi:10.1016/s0022-5347(17)44267-4

Cited by 577 publications

(271 citation statements)

References 26 publications

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“…The origin of the nervous system signal that induces erection is unknown. 9 The RigiScan device makes it possible to measure the erectile event duration and the rigidity. No single normality criterion has been reported for the assessment of RigiScan results as regards rigidity percentage or duration.…”

Section: Discussionmentioning

confidence: 99%

Sildenafil improves nocturnal penile erections in organic impotence

et al. 2001

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We studied the effects of sildena®l on nocturnal penile erections. We prospectively evaluated 36 patients with organic or psychogenic impotence and 5 normal, potent men. All patients completed 3 sessions of consecutive nights using the RigiScan Plus device. The ®rst two nights the patients were asked to take placebo before the session and to take 50 mg of sildena®l before the third session. In the organic impotence group the use of sildena®l induced a signi®cant improvement in time of rigidity 60 ± 100%, rigidity and tumescence activity unit values and rigidity and tumescence activity unit values per hour in the tip and base. In the psychogenic impotence group it caused signi®cant improvement only in rigidity activity unit per hour in the tip. In the potent men, changes were statistically insigni®cant. Sildena®l improves nocturnal penile erectile activity in organic impotence. Our study shows that phosphodiesterase inhibitors can improve penile erections not induced by sexual stimulation.

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Section: Discussionmentioning

confidence: 99%

Sildenafil improves nocturnal penile erections in organic impotence

et al. 2001

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“…All patients were observed in the office until full detumescence occurred. Those patients with full erection persisting for more than 2 1 2 h were then treated with oral medication, either terbutaline 5 mg or placebo (sodium bicarbonate) and observed for 15 min. An additional dosage of 5 mg was given if detumescence did not occur after 15 min and 30 min.…”

Section: Methodsmentioning

confidence: 99%

“…Various vasoactive compounds as intracorporeal injections have been used in both the diagnostic evaluation and treatment of impotence. 1 Pharmacologically induced erections have various potential complications of which the most significant is prolonged erection or priapism. 2 The incidence of prolonged erection ranges from 2 to 18% depending upon the type of agent and the amount of dose used.…”

Section: Introductionmentioning

confidence: 99%

Oral terbutaline in the management of pharmacologically induced prolonged erection

Priyadarshi

2004

Int J Impot Res

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Prolonged erection and priapism are common complications following intracavernosal injection of vasoactive agents in the management of erectile dysfunction. It is usually treated by intracorporeal drainage and irrigation with sympathomimetic agents. There is no established oral therapy . To study the effect of oral terbutaline on prolonged erection following intracavernosal injection of vasoactive agent, a controlled randomized study was done in 68 patients. Detumescence was achieved in 42 and 15% of the cases with oral terbutaline and placebo, respectively. Results of this study suggest that an initial trial with oral terbutaline for pharmacologically induced prolonged erection may be successful.

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“…6 Radiographic studies of venous drainage after intracavernous contrast injection with dilute contrast (Conray 43, Mallinckrodt Medical, St. Louis, MO) provided visual demonstration of the abnormal venous system. Patients with normal duplex ultrasound studies and abnormal DICC studies were included in group 2 (venogenicavenous leak group).…”

Section: Methodsmentioning

confidence: 99%

Vasculogenic impotence and cavernosal oxygen tension

Strohl

et al. 2000

Int J Impot Res

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Aims of this study: To determine the associations, if any, of cavernosal oxygen tension with vasculogenic impotence. Materials and Methods: We evaluated penile cavernosal blood gas levels in men with suspected vasculogenic impotence during penile duplex ultrasonography andaor dynamic infusion cavernosometry and cavernosography (DICC). Patients with suspected impotence were evaluated from 1992 ± 1996. Patient ages ranged from 24 ± 75 y (mean 48 y). Eighteen men had arteriogenic impotence diagnosed by abnormal penile duplex ultrasound after injection of a vasoactive agent, and 23 men had venous leakage diagnosed by DICC. Results: Eighteen men with arteriogenic impotence had the following mean blood gas values: pH 7.38 AE 0.01, PCO2 45.50 AE 0.94, PO2 65.17 AE 2.16. Twenty-three men with venogenic (venous leak) impotence had the following mean cavernosal blood gas values: pH 7.41 AE 0.01, PCO2 42.26 AE 0.83, PO2 74.17 AE 2.51. The differences in PO2 were signi®cant (P`0.05). A subgroup of men with severe venous leakage had PO2 values that were similar to the low arterial PO2 values. Conclusion: The low PO2 in patients with arteriogenic impotence, and the subset of men with severe venous leak impotence, support a global concept of low cavernosal PO2 as a mechanism for both arteriogenic and venogenic impotence.

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Physiology of Erection and Pharmacological Management of Impotence

Cited by 577 publications

References 26 publications

Sildenafil improves nocturnal penile erections in organic impotence

Sildenafil improves nocturnal penile erections in organic impotence

Oral terbutaline in the management of pharmacologically induced prolonged erection

Vasculogenic impotence and cavernosal oxygen tension

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