Physiology of guanosine-based second messenger signaling in Bacillus subtilis

Bange, Gert; Bedrunka, Patricia

doi:10.1515/hsz-2020-0241

Cited by 9 publications

(7 citation statements)

References 140 publications

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“…Concentration of c-di-GMP increases in bacterial cells in response to environmental stress condition. Concentration of c-di-GMP is very important in regulating motility (inhibit motility) [ 75 ]. Phosphodiesterase (PDE) proteins enhance motility by degrading c-di-GMP.…”

Section: Motilitymentioning

confidence: 99%

Molecular genetics of surfactin and its effects on different sub-populations of Bacillus subtilis

Rahman

Sarkar

Moni

et al. 2021

Biotechnology Reports

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Section: Motilitymentioning

confidence: 99%

Molecular genetics of surfactin and its effects on different sub-populations of Bacillus subtilis

Rahman

Sarkar

Moni

et al. 2021

Biotechnology Reports

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“…Probably, loss of ClpY function can be compensated by other Clp ATPases. The dgcB gene encodes one of three diguanylate cyclases in L. monocytogenes for formation of the second messenger c-di-GMP ( 51 , 52 ). Their redundancy might explain that one of them can be lost without impairing viability and virulence.…”

Section: Discussionmentioning

confidence: 99%

Large Multicountry Outbreak of Invasive Listeriosis by a Listeria monocytogenes ST394 Clone Linked to Smoked Rainbow Trout, 2020 to 2021

et al. 2023

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“…IAA is an ubiquitous signaling molecule responsive to different stress conditions ( Somers et al, 2005 ; Bianco et al, 2006 ; Zarkan et al, 2020 ). Finally, we see guanosine, which can play regulatory roles in stress response, biofilm formation, and cellular damage protection ( Cornforth and Foster, 2013 ; Rowlett et al, 2017 ; Bange and Bedrunka, 2020 ). Thus, the observations at this growth phase suggest the cells elucidating general stress response adapting to the

loaded environment.…”

Section: Discussionmentioning

confidence: 99%

Untargeted Metabolomics Investigation on Selenite Reduction to Elemental Selenium by Bacillus mycoides SeITE01

et al. 2021

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Bacillus mycoides SeITE01 is an environmental isolate that transforms the oxyanion selenite (SeO32−) into the less bioavailable elemental selenium (Se0) forming biogenic selenium nanoparticles (Bio-SeNPs). In the present study, the reduction of sodium selenite (Na2SeO3) by SeITE01 strain and the effect of SeO32− exposure on the bacterial cells was examined through untargeted metabolomics. A time-course approach was used to monitor both cell pellet and cell free spent medium (referred as intracellular and extracellular, respectively) metabolites in SeITE01 cells treated or not with SeO32−. The results show substantial biochemical changes in SeITE01 cells when exposed to SeO32−. The initial uptake of SeO32− by SeITE01 cells (3h after inoculation) shows both an increase in intracellular levels of 4-hydroxybenzoate and indole-3-acetic acid, and an extracellular accumulation of guanosine, which are metabolites involved in general stress response adapting strategies. Proactive and defensive mechanisms against SeO32− are observed between the end of lag (12h) and beginning of exponential (18h) phases. Glutathione and N-acetyl-L-cysteine are thiol compounds that would be mainly involved in Painter-type reaction for the reduction and detoxification of SeO32− to Se0. In these growth stages, thiol metabolites perform a dual role, both acting against the toxic and harmful presence of the oxyanion and as substrate or reducing sources to scavenge ROS production. Moreover, detection of the amino acids L-threonine and ornithine suggests changes in membrane lipids. Starting from stationary phase (24 and 48h), metabolites related to the formation and release of SeNPs in the extracellular environment begin to be observed. 5-hydroxyindole acetate, D-[+]-glucosamine, 4-methyl-2-oxo pentanoic acid, and ethanolamine phosphate may represent signaling strategies following SeNPs release from the cytoplasmic compartment, with consequent damage to SeITE01 cell membranes. This is also accompanied by intracellular accumulation of trans-4-hydroxyproline and L-proline, which likely represent osmoprotectant activity. The identification of these metabolites suggests the activation of signaling strategies that would protect the bacterial cells from SeO32− toxicity while it is converting into SeNPs.

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Physiology of guanosine-based second messenger signaling in Bacillus subtilis

Cited by 9 publications

References 140 publications

Molecular genetics of surfactin and its effects on different sub-populations of Bacillus subtilis

Molecular genetics of surfactin and its effects on different sub-populations of Bacillus subtilis

Large Multicountry Outbreak of Invasive Listeriosis by a Listeria monocytogenes ST394 Clone Linked to Smoked Rainbow Trout, 2020 to 2021

Untargeted Metabolomics Investigation on Selenite Reduction to Elemental Selenium by Bacillus mycoides SeITE01

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