Physiology of Natriuretic Peptides

Espiner, Eric A.

doi:10.1007/978-1-4612-3960-4_8

Cited by 15 publications

(12 citation statements)

References 107 publications

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“…Groban et al [162] demonstrated in humans that lowdose systemic ANP infusion reduced CVP without affecting BP. It is now generally accepted that the fall in CO/BP following systemic infusion of ANP is a consequence of reduced preload [163], and the mechanisms involved may include volume contraction as a consequence of diuresis and increased capillary filtration [74,164,165], and direct venodilatation [141]. While the former is well documented, evidence for the latter is sparse and ambivalent.…”

Section: Cardiovascular Effectsmentioning

confidence: 99%

Modulation of the natriuretic peptide system in heart failure: from bench to bedside?

2003

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Since the discovery of atrial natriuretic peptide, the unravelling of the natriuretic peptide system has been a story of scientific success. However, bridging the gap between bench and bedside has proved difficult, and as yet has not provided any major clinical progress. In this review we will first give a detailed outline of the key elements constituting the natriuretic peptide system. Secondly, we will briefly explain the underlying rationale, basic concepts and evidence behind currently pursued strategies to potentiate the natriuretic peptide system. Thirdly, we will highlight some of the problems that have so far hindered successful translation of these theoretically viable treatment options into tangible clinical progress.

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Section: Cardiovascular Effectsmentioning

confidence: 99%

Modulation of the natriuretic peptide system in heart failure: from bench to bedside?

2003

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“…*p<0.05 vs. respective Nppa +/+ groups, yp<0.05 vs. respective control unoperated groups. taraldehyde and 4.5% sucrose (1). The samples were placed into 10% formaldehyde, and then dehydrated in graded concentrations of ethanol, immersed in xylene, and finally embedded in paraffin.…”

Section: Histological Analysismentioning

confidence: 99%

“…Atrial natriuretic peptide (ANP) is a peptide hormone that has potent natriuretic, diuretic, vasodilator, sympatholytic, and renin-and aldosterone-suppressing activities and is involved in the regulation of volume and electrolyte balance and blood pressure [1,2]. Recent studies have demonstrated that ANP is also involved in the direct regulation of cardiac growth [3][4][5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Volume overload results in exaggerated cardiac hypertrophy in the atrial natriuretic peptide knockout mouse

Mori

Chen

Feng

et al. 2004

Cardiovascular Research

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“…In addition, natriuretic peptides reduce cardiac output by shifting fluid from the intravascular to the extravascular compartment, an effect mediated by increased capillary hydraulic conductivity to water [35]. In this context, natriuretic peptide provokes vasorelaxation, which leads to reduced preload and subsequently to a fall in cardiac output [36,37]. Moreover, natriuretic peptides inhibit the activity…”

Section: Physiology Of Natriuretic Peptidesmentioning

confidence: 98%

“…Finally, natriuretic peptides have also been shown to exert antiproliferative, growth-regulatory properties in cultured glomerular mesangial cells, cardiomyocytes, cardiac fibroblasts, vascular smooth muscle cells (VSMCs), and endothelial cells [11,21,36,37].…”

Section: Key Pointsmentioning

confidence: 99%