“…Loss of function of PINK1 is closely associated with early-onset of Parkinson’s disease (PD)(Reed et al, 2019,Pickrell et al, 2015), a neurodegenerative disease characterized by the dysfunction of dopaminergic (DA) neurons in the substantia nigra (SN)(Goldstein et al, 2019,Poewe et al, 2017). The pathology of PD caused by PINK1 mutationsis unclear, largely due to that the PINK1 knock-out mouse and pig models were unable to recapitulate the typical PD-associated symptoms observed in human patients(Nakamura et al, 2007,Dawson et al, 2010,Zhou et al, 2015). Thus, it is necessary to generate a PINK1 mutant animal model in non-human primates (NHPs),which show high similarity to human, to uncover the unique function of PINK1 in primate brains.…”